DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45263 and Il18r1

DIOPT Version :9

Sequence 1:	NP_731246.2	Gene:	CG45263 / 50003	FlyBaseID:	FBgn0266801	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_032391.1	Gene:	Il18r1 / 16182	MGIID:	105383	Length:	537	Species:	Mus musculus

Alignment Length:	393	Identity:	84/393 - (21%)
Similarity:	136/393 - (34%)	Gaps:	102/393 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 YHESYTAKSVVVEARLDVKYAPSIRLIGSPEIDLEEDKDALVLRCVADA----NPPASIVWRRAG 324
            :||    :.::....|.||.| |...|...:|.:.|.:...:..|...|    |..|::.|.:..
Mouse     2 HHE----ELILTLCILIVKSA-SKSCIHRSQIHVVEGEPFYLKPCGISAPVHRNETATMRWFKGS 61

  Fly   325 RS------------EIASLQETLQLRPVGRRDAGLYTCQAQNSVGTSEQ---LSVQLDVKYPPKI 374
            .|            .:.....||:..||...|.|.|..|    ||...:   |:|....|:
Mouse    62 ASHEYRELNNRSSPRVTFHDHTLEFWPVEMEDEGTYISQ----VGNDRRNWTLNVTKRNKH---- 118

  Fly   375 ISAGPDRLTTA-----------PLFSPAAFECLADGNPLPSFKWVQRMAHGSKYVERGSESRLVI 428
             |...|:|.|:           ...:|...|.:.|       .|:.      |..:..|::..::
Mouse   119 -SCFSDKLVTSRDVEVNKSLHITCKNPNYEELIQD-------TWLY------KNCKEISKTPRIL 169

  Fly   429 DNVTYEYQGEYECRATSYINGQERVAISDPVSLQVV-GAPQVLR--LHPSLHTVSVKRGEAASLT 490
            .:..:..:|.|.|..:.:.|| .|..|:..|::.|: |..:|..  |.|....|.|:.|:...|.
Mouse   170 KDAEFGDEGYYSCVFSVHHNG-TRYNITKTVNITVIEGRSKVTPAILGPKCEKVGVELGKDVELN 233

  Fly   491 MVVCADPRPQRVAWEWGSLRLEAGSGIDRFRADDMQPDTREDCYLSTLHILHADEHDSR------ 549
               |:....:...:.| |:|.|          |...|:.:||...:|..|.....|.|:
Mouse   234 ---CSASLNKDDLFYW-SIRKE----------DSSDPNVQEDRKETTTWISEGKLHASKILRFQK 284

  Fly   550 --------PYYLVVENERGTDRHAIHLI------VEG-TFAEPYEMSYLMGVAGGCMAAILLLVC 599
                    .|...|.||...|..:..|:      :.| .|.....:..|..||..|      :|.
Mouse   285 ITENYLNVLYNCTVANEEAIDTKSFVLVRKEIPDIPGHVFTGGVTVLVLASVAAVC------IVI 343

  Fly   600 LCI 602
            ||:
Mouse   344 LCV 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45263	NP_731246.2	I-set	53..149	CDD:254352
		Ig	198..281	CDD:299845	3/16 (19%)
		IG_like	302..368	CDD:214653	18/84 (21%)
		IGc2	302..357	CDD:197706	14/70 (20%)
		Ig	372..446	CDD:299845	13/84 (15%)
		Ig	475..568	CDD:299845	22/106 (21%)
		IG_like	478..570	CDD:214653	23/111 (21%)
Il18r1	NP_032391.1	IG_like	26..112	CDD:214653	19/89 (21%)
		Ig	131..205	CDD:386229	15/87 (17%)
		PHA02785	<157..257	CDD:165149	25/114 (22%)
		TIR	374..534	CDD:366714
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910