DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45263 and Il1rap

DIOPT Version :9

Sequence 1:	NP_731246.2	Gene:	CG45263 / 50003	FlyBaseID:	FBgn0266801	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_001152790.1	Gene:	Il1rap / 16180	MGIID:	104975	Length:	685	Species:	Mus musculus

Alignment Length:	680	Identity:	128/680 - (18%)
Similarity:	212/680 - (31%)	Gaps:	241/680 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 LWIRSATLDFDDGLWECQVTASDFTTQDALTSQPVRLVVRVAPQRPRLEYEAVHVPPGHNITADA 194
            ||.|...|: |.|.:.|.:..:.:.::.|.   |:.:|.:.:.....:.:      |.|.:..:.
Mouse    99 LWFRPTLLN-DTGNYTCMLRNTTYCSKVAF---PLEVVQKDSCFNSAMRF------PVHKMYIEH 153

  Fly   195 GALATVKCISHYGNPPATLK----WFLGDQEISPIH---PQ-MN-----------------ATEP 234
            | :..:.|.:..|..|:::|    |:.|..||...|   |: ||                 .|.|
Mouse   154 G-IHKITCPNVDGYFPSSVKPSVTWYKGCTEIVDFHNVLPEGMNLSFFIPLVSNNGNYTCVVTYP 217

  Fly   235 DNPRTWSATSVVQVSAMRERHGDILRCAAYHESYTAKSVVVEARLDVK----YAPSIRLIGSPEI 295
            :|.|.:..|..|.|.                        ||.:..|..    |:|:.|::..
Mouse   218 ENGRLFHLTRTVTVK------------------------VVGSPKDALPPQIYSPNDRVVYE--- 255

  Fly   296 DLEEDKDALVLRC------VADANPPASIVWRRAGR-----------SEIASLQET--------L 335
              :|..:.||:.|      :.|::  ..:.|...|:           :|..|...|        |
Mouse   256 --KEPGEELVIPCKVYFSFIMDSH--NEVWWTIDGKKPDDVTVDITINESVSYSSTEDETRTQIL 316

  Fly   336 QLRPVGRRDAGL-YTCQAQNSVGTSEQLSVQLDVKYPPKIISAGPDRLTT--------------- 384
            .::.|...|... |.|.|:|:.|.:||.:     |...|:|   |.|.|.
Mouse   317 SIKKVTPEDLRRNYVCHARNTKGEAEQAA-----KVKQKVI---PPRYTVELACGFGATVFLVVV 373

  Fly   385 -----------APLFSPAAF---ECLADGNPLPSFKWVQRMAHGSKYVERGSESRLVIDNVTYEY 435
                       ..||..|.|   |.:.||.....:         ..|.....|...|:..:....
Mouse   374 LIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIY---------VSYARNVEEEEFVLLTLRGVL 429

  Fly   436 QGEYECR-----ATSYINGQERVAISDPVS----LQVVGAPQVLRLHPSLHTVSVKRG---EAAS 488
            :.|:..:     ..|...|....|:.|.:.    :.||.:|..: ...|:..:..|.|   :.:.
Mouse   430 ENEFGYKLCIFDRDSLPGGNTVEAVFDFIQRSRRMIVVLSPDYV-TEKSISMLEFKLGVMCQNSI 493

  Fly   489 LTMVVCADPRPQR---------------VAWE-----------WGSLR-------LEAGSGIDRF 520
            .|.::..:.||..               |:|:           |.:||       |.|.||
Mouse   494 ATKLIVVEYRPLEQPHPGIMQLKESVSFVSWKGEKSKHSGSKFWKALRLALPLRSLSASSG---- 554

  Fly   521 RADDMQPDTREDCYLSTLHILHADEHDSRPYYLVVENERGTDRHAIHLIVEGTFAEPYEMSYLMG 585
                    ..|.|  |:...:..|....|.........|.::|      |.|....|..||...|
Mouse   555 --------WNESC--SSQSDISLDHVQRRSRLKEPPELRSSER------VSGAEPAPGTMSKHRG 603

  Fly   586 -VAGGCMAAILLLVCLCIYAIKSKRCCF---KGSTGYKSSDKDSEKADLKSRSDSTSGPQGDSIY 646
             .:..|                  |||.   :|.:..:|          |||::..:.||.::..
Mouse   604 KPSAAC------------------RCCVTYCEGESHLRS----------KSRAEMHTHPQWETHL 640

  Fly   647 TTPAGFHHHQQQQQQQQQQQHAAAAAAAAL 676
            ..|.......|..|...:.:.|...:|.||
Mouse   641 CKPPLQESESQWIQNGTRPEPAPQISALAL 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45263	NP_731246.2	I-set	53..149	CDD:254352	7/18 (39%)
		Ig	198..281	CDD:299845	21/107 (20%)
		IG_like	302..368	CDD:214653	19/91 (21%)
		IGc2	302..357	CDD:197706	16/80 (20%)
		Ig	372..446	CDD:299845	16/107 (15%)
		Ig	475..568	CDD:299845	22/128 (17%)
		IG_like	478..570	CDD:214653	21/127 (17%)
Il1rap	NP_001152790.1	Ig1_IL1R_like	25..132	CDD:409584	9/36 (25%)
		Ig strand B	43..47	CDD:409584
		Ig strand C	67..71	CDD:409584
		Ig strand E	97..101	CDD:409584	1/1 (100%)
		Ig strand F	111..116	CDD:409584	1/4 (25%)
		Ig strand G	124..127	CDD:409584	0/2 (0%)
		Ig	145..235	CDD:416386	23/114 (20%)
		Ig strand A	145..150	CDD:409353	2/4 (50%)
		Ig strand A	145..150	CDD:409353	2/4 (50%)
		Ig strand B	156..160	CDD:409353	0/3 (0%)
		Ig strand B	156..160	CDD:409353	0/3 (0%)
		Ig strand C	174..179	CDD:409353	1/4 (25%)
		Ig strand C	174..179	CDD:409353	1/4 (25%)
		Ig strand C'	182..184	CDD:409353	0/1 (0%)
		Ig strand C'	182..184	CDD:409353	0/1 (0%)
		Ig strand D	189..193	CDD:409353	0/3 (0%)
		Ig strand D	189..193	CDD:409353	0/3 (0%)
		Ig strand E	195..200	CDD:409353	2/4 (50%)
		Ig strand E	195..200	CDD:409353	2/4 (50%)
		Ig strand F	209..218	CDD:409353	1/8 (13%)
		Ig strand F	209..218	CDD:409353	1/8 (13%)
		Ig strand G	221..234	CDD:409353	4/36 (11%)
		Ig strand G	221..234	CDD:409353	4/36 (11%)
		Ig3_IL1RAP	243..349	CDD:409525	24/117 (21%)
		Ig strand B	262..266	CDD:409525	2/3 (67%)
		Ig strand C	279..283	CDD:409525	0/3 (0%)
		Ig strand E	314..318	CDD:409525	1/3 (33%)
		Ig strand F	329..334	CDD:409525	2/4 (50%)
		Ig strand G	341..344	CDD:409525	1/2 (50%)
		TIR	404..547	CDD:214587	22/152 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910