DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45263 and Il1r2

DIOPT Version :9

Sequence 1:	NP_731246.2	Gene:	CG45263 / 50003	FlyBaseID:	FBgn0266801	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_446405.1	Gene:	Il1r2 / 117022	RGDID:	621147	Length:	416	Species:	Rattus norvegicus

Alignment Length:	449	Identity:	95/449 - (21%)
Similarity:	156/449 - (34%)	Gaps:	148/449 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 AAYHESYTAKSVVVEARLDV----------KYAPSIRLIGSPEIDLEEDKDALVLRC--VADANP 314
            |..|....::|.|...:..|          .:...:||.|.|          :||||  |..::.
  Rat    18 AVVHTGRVSESPVTSEKHPVLGDDCWFRGRDFKSELRLEGEP----------VVLRCPLVPHSDT 72

  Fly   315 PAS----IVWRRAGRSEIASLQE--------TLQLRPVGRRDAGLYTCQAQNSVGTSEQLSVQLD 367
            .:|    :.|.::..|::....|        ||.:.|..::|:|.|.|..:|: ...||:|::|.
  Rat    73 SSSSRSLLTWSKSDSSQLIPGDEPRMWVKDDTLWVLPAVQQDSGTYICTFRNA-SHCEQMSLELK 136

  Fly   368 V------KYPPKIISAGPDRLTTAPLFSPAAFEC---------LADGNPLPSFKWVQRMAHGS-- 415
            |      .:|  ::|    .|..:.|.|.....|         ..||    ..:|.:    ||
  Rat   137 VFKNTEASFP--LVS----YLQISALSSTGLLVCPDLKEFISSRTDG----KIQWYK----GSIL 187

  Fly   416 ------KYVERGSESRLVIDNVTYEYQGEYECRATSYINGQERVAISDPVSLQVVG---APQVLR 471
                  |::..|..:||:|.|.:....|.|.|..|....|:| ..|:..:.|:|.|   .|..:.
  Rat   188 LDKGNKKFLSAGDPTRLLISNTSMGDAGYYRCVMTFTYEGKE-YNITRNIELRVKGITTEPIPVI 251

  Fly   472 LHPSLHTVSVKRGE----------------------AASLTMVVCADPRPQRVAWEWGSLRLEAG 514
            :.| |.|:....|.                      .|:.|.:..|.||.          |:..|
  Rat   252 ISP-LETIPASLGSRLIVPCKVFLGTGTSSNTIVWWMANSTFISVAYPRG----------RVTEG 305

  Fly   515 SGIDRFRADD--------MQPDTREDCYLSTLHILHADEHDSRPYYLVVENERGTDRHAIHLIVE 571
            ........|:        ..|.|:||        |:.|      :..|..|.|..  .::|
  Rat   306 LHHQYSENDENYVEVSLIFDPVTKED--------LNTD------FKCVATNPRSF--QSLH---- 350

  Fly   572 GTFAEPYEMSYLMGVAGGCMAAILLLVCLCIYAIKSKRCCFK------GSTGYKSSDKD 624
             |..:....::..|:|    .|.|.|:.|.:.||..:|.|.:      |.|...:.::|
  Rat   351 -TTVKEVSSTFSWGIA----LAPLSLIILVVGAIWIRRRCKRQAGKTYGLTKLPTDNQD 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45263	NP_731246.2	I-set	53..149	CDD:254352
		Ig	198..281	CDD:299845	4/18 (22%)
		IG_like	302..368	CDD:214653	21/79 (27%)
		IGc2	302..357	CDD:197706	17/68 (25%)
		Ig	372..446	CDD:299845	20/90 (22%)
		Ig	475..568	CDD:299845	20/122 (16%)
		IG_like	478..570	CDD:214653	20/121 (17%)
Il1r2	NP_446405.1	PHA02826	38..240	CDD:165173	51/227 (22%)
		Ig	44..137	CDD:299845	25/103 (24%)
		Ig	148..242	CDD:299845	25/106 (24%)
		I-set	249..343	CDD:254352	19/118 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..416		2/9 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910