DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG45263 and IL1RAPL1

DIOPT Version :9

Sequence 1:NP_731246.2 Gene:CG45263 / 50003 FlyBaseID:FBgn0266801 Length:1876 Species:Drosophila melanogaster
Sequence 2:NP_055086.1 Gene:IL1RAPL1 / 11141 HGNCID:5996 Length:696 Species:Homo sapiens


Alignment Length:540 Identity:110/540 - (20%)
Similarity:165/540 - (30%) Gaps:213/540 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   141 DGLWECQVTASDFTTQDALTSQPVRLVVRVAPQRPRLEYEAVHVPPGHNITADAGALATVKCISH 205
            ||   |...:.|......|..:|||                                  :||...
Human    29 DG---CTDWSIDIKKYQVLVGEPVR----------------------------------IKCALF 56

  Fly   206 YG----------NPPATLKWFL----GDQEISPIHPQMNATEPDNPRTWSATSVVQVSAMRERHG 256
            ||          :...:|.|:.    ||.| .||....:....:....|...:::|.|.      
Human    57 YGYIRTNYSLAQSAGLSLMWYKSSGPGDFE-EPIAFDGSRMSKEEDSIWFRPTLLQDSG------ 114

  Fly   257 DILRCAAYHESYTAKSVVVEARLDV-------------KYAPSIRLIGSPEIDLEEDKDALVLRC 308
             :..|...:.:|..|   |...|.|             ||.....|..|.||...:.:|.|:   
Human   115 -LYACVIRNSTYCMK---VSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIEDFLL--- 172

  Fly   309 VADANPPASIVW-----RRAGRSEIASLQETLQLRPVGRRDAGLYTCQAQNS---VGTSEQLSVQ 365
              ....| .|:|     .:..|..|...::||.:|.|...|.|.|||:.:..   |..:.:|:|.
Human   173 --PTREP-EILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGGFVVRRTTELTVT 234

  Fly   366 LDV-KYPPKIISAGPDRLT--TAPLFSPAAFECLA----DGNPLPSFKWVQRMAHGSKYVERGSE 423
            ..: ..|||::.....:||  ...|...|...|.|    .|:..|...|::    |.|::|...|
Human   235 APLTDKPPKLLYPMESKLTIQETQLGDSANLTCRAFFGYSGDVSPLIYWMK----GEKFIEDLDE 295

  Fly   424 SRLVIDNVTYEYQGEYECRATSYINGQERVAISDPVSLQVVGAPQVLRLHPSLHTVSVKRGEAAS 488
            :|:          .|.:.|......|::.|:|                   ||...||:.|:..:
Human   296 NRV----------WESDIRILKEHLGEQEVSI-------------------SLIVDSVEEGDLGN 331

  Fly   489 LTMVVCADPRPQRVAWEWGSLRLEAGSGIDRFRADDMQPDTREDCYLSTLHILHADEHDSRPYYL 553
            .:                                          ||                   
Human   332 YS------------------------------------------CY------------------- 335

  Fly   554 VVENERGTDRHAIHLIVEGTFAEPYEMSYLMGVAGGCMAAILLLVCL-CIYAIKSKRCCFK---- 613
             |||..|. |||..|:      ...|:.|.:.:|||..|.:|||||| .||.      |:|    
Human   336 -VENGNGR-RHASVLL------HKRELMYTVELAGGLGAILLLLVCLVTIYK------CYKIEIM 386

  Fly   614 ----GSTGYKSSDKDSEKAD 629
                ...|.:..|.|::..|
Human   387 LFYRNHFGAEELDGDNKDYD 406

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG45263NP_731246.2 I-set 53..149 CDD:254352 3/7 (43%)
Ig 198..281 CDD:299845 19/96 (20%)
IG_like 302..368 CDD:214653 19/73 (26%)
IGc2 302..357 CDD:197706 16/62 (26%)
Ig 372..446 CDD:299845 18/79 (23%)
Ig 475..568 CDD:299845 14/92 (15%)
IG_like 478..570 CDD:214653 13/91 (14%)
IL1RAPL1NP_055086.1 Ig1_IL1RAPL-1_like 32..135 CDD:143304 24/147 (16%)
Ig 148..239 CDD:386229 25/96 (26%)
IGc2 260..341 CDD:197706 26/175 (15%)
TIR 405..559 CDD:366714 1/2 (50%)
Interaction with NCS1. /evidence=ECO:0000269|PubMed:12783849 549..644
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 659..680
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.