DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45263 and Kirrel2

DIOPT Version :9

Sequence 1:	NP_731246.2	Gene:	CG45263 / 50003	FlyBaseID:	FBgn0266801	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	XP_038957463.1	Gene:	Kirrel2 / 100359836	RGDID:	1308456	Length:	711	Species:	Rattus norvegicus

Alignment Length:	640	Identity:	171/640 - (26%)
Similarity:	256/640 - (40%)	Gaps:	123/640 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 VASCLP---GSEGFQRFSEQPKYTEVNPAEDTLLTCKVIDKRGTCSWQKDNKPVGIYTKKYEWAS 102
            ::|.:|   ||.  ..|.:||:...|...::..|.|.:...||...|.||...:|.......| |
  Rat    20 LSSAIPLLLGSS--PHFLQQPEDMVVLLGQEARLPCALGAYRGLVQWTKDGLALGGERDLPGW-S 81

  Fly   103 RMPTSDNGNVLHLDLHPPPVQLGGDCSLWIRSATLDFDDGLWECQVTASDFTTQDALTSQPVRLV 167
            |...|.|......|||..||:|.              |:..:|||      .:|..|.|:|.:|.
  Rat    82 RYWISGNSASGQHDLHIKPVELE--------------DEASYECQ------ASQAGLRSRPAQLH 126

  Fly   168 VRVAPQRPRLEYEAVHVPPGHNITADAGALATVKCISHYGNPPA-TLKWFLGDQEI--SPIHPQM 229
            |.|.|:.|:       |..|.:::..||....:.|.|.....|| .|.||.....:  :..| |:
  Rat   127 VMVPPEAPQ-------VLGGPSVSLVAGVPGNLTCRSRGDARPAPELLWFRDGIRLDGTSFH-QI 183

  Fly   230 NATEPDNPRTWSATSVVQ----VSAMRERHGDILRCAAYHESY-TAKSVVVEARLDVKYAPSIRL 289
            ...:       .||..|:    ::...:..|..|.|.|..::. |.:...|  .|.::|.|.:.|
  Rat   184 TLRD-------KATGTVENTLFLTPSSQDDGATLICRARSQALPTGRDTAV--TLSLQYPPMVTL 239

  Fly   290 IGSPEIDLEEDKDALVLRCVADANPPAS-IVWRRAG---------RSEIASLQETLQLRPVGRRD 344
            ...|:...|.:|  :...|.|.|.||.: ..|.:.|         |.|:.: ..|....||
  Rat   240 SAEPQTAQEGEK--VTFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVA-DATFLTEPV---- 297

  Fly   345 AGLYTCQAQNSVGTSEQLSVQLDVKYPPKIISAGPDRLTTAPLFSPAAFECLADGNPLPSFKWVQ 409
                :|:..|:||::.: |..|:|.|.| |:.|.| :..:..:...|:|.|:..|||||...|.:
  Rat   298 ----SCEVSNAVGSANR-STALEVLYGP-ILQAKP-KPVSVDVGKDASFSCVWRGNPLPRISWTR 355

  Fly   410 RMAHGSKYVERGSESRLVIDNVTYEYQGEYECRATSYING------QERVAISDPVSLQVVGAPQ 468
              ..||:.:..|...||  .:|..|..|:|.|||.....|      |.|:.::.|        |.
  Rat   356 --LGGSQVLSSGPTLRL--PSVALEDAGDYVCRAEPRRTGVGGGTAQARLTVNAP--------PV 408

  Fly   469 VLRLHPSLHTVSVKRGEAASLTMVVCADPRPQRVAWEWGSLRLEAGS-G---IDRFRADDMQ--- 526
            |..|||:   .:..|| .|.|..||.|.|.|..|.|.|....||||| |   ::.|.|.:::
  Rat   409 VTALHPA---PAFLRG-PARLQCVVFASPAPDSVVWSWDEGFLEAGSLGRFLVEAFPAPEVEGGQ 469

  Fly   527 -PDTREDCYLSTLHILHADEHD-SRPYYLVVENERGTDRHAIHLIVEGTFAEPYEMSYLMGVAGG 589
             |.     .:|.|||....|.| :..:.....|..|..|..|||      .....:..:..|||.
  Rat   470 GPG-----LISVLHISGTQESDFTTGFNCSARNRLGEGRVQIHL------GRRDLLPTVRLVAGA 523

  Fly   590 CMAAILLLVCLCIYAIKSKRCCFKGSTGYKSSDKDSEKADLKSRSDSTSGPQGDS 644
            ..||..|.:.:....:    ||::  .|..|..|:..:....|...|..||:.::
  Rat   524 ASAATSLFMVITGVVL----CCWR--HGSLSKQKNLVRIPGSSEGSSAHGPEEET 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45263	NP_731246.2	I-set	53..149	CDD:254352	27/95 (28%)
		Ig	198..281	CDD:299845	19/90 (21%)
		IG_like	302..368	CDD:214653	18/75 (24%)
		IGc2	302..357	CDD:197706	14/64 (22%)
		Ig	372..446	CDD:299845	25/73 (34%)
		Ig	475..568	CDD:299845	31/101 (31%)
		IG_like	478..570	CDD:214653	33/100 (33%)
Kirrel2	XP_038957463.1	IG_like	38..127	CDD:214653	30/109 (28%)
		Ig strand A'	40..44	CDD:409353	0/3 (0%)
		Ig strand B	48..57	CDD:409353	2/8 (25%)
		Ig strand C	62..66	CDD:409353	1/3 (33%)
		Ig strand D	75..85	CDD:409353	3/10 (30%)
		Ig strand E	88..100	CDD:409353	4/11 (36%)
		Ig strand F	107..115	CDD:409353	3/13 (23%)
		Ig strand G	117..127	CDD:409353	4/9 (44%)
		Ig	133..231	CDD:416386	24/114 (21%)
		Ig strand A	134..137	CDD:409353	1/9 (11%)
		Ig strand A'	140..144	CDD:409353	0/3 (0%)
		Ig strand B	151..158	CDD:409353	2/6 (33%)
		Ig strand C	164..169	CDD:409353	1/4 (25%)
		Ig strand C'	172..174	CDD:409353	0/1 (0%)
		Ig strand D	177..184	CDD:409353	2/7 (29%)
		Ig strand E	191..199	CDD:409353	1/7 (14%)
		Ig strand F	208..216	CDD:409353	3/7 (43%)
		Ig strand G	222..228	CDD:409353	1/7 (14%)
		Ig_3	234..303	CDD:404760	18/79 (23%)
		Ig strand B	252..256	CDD:409353	0/3 (0%)
		Ig strand C	266..270	CDD:409353	0/3 (0%)
		Ig strand E	283..286	CDD:409353	1/2 (50%)
		Ig strand F	292..301	CDD:409353	3/16 (19%)
		Ig strand G	309..312	CDD:409353	0/3 (0%)
		Ig	326..403	CDD:416386	25/81 (31%)
		Ig strand A'	327..332	CDD:409353	0/4 (0%)
		Ig strand B	335..344	CDD:409353	3/8 (38%)
		Ig strand C	350..354	CDD:409353	0/3 (0%)
		Ig strand C'	357..359	CDD:409353	0/1 (0%)
		Ig strand D	362..365	CDD:409353	0/2 (0%)
		Ig strand E	366..371	CDD:409353	2/6 (33%)
		Ig strand F	379..387	CDD:409353	5/7 (71%)
		Ig strand G	393..403	CDD:409353	2/9 (22%)
		Ig	405..509	CDD:416386	39/126 (31%)
		Ig strand A	406..410	CDD:409353	2/11 (18%)
		Ig strand A'	412..415	CDD:409353	2/2 (100%)
		Ig strand B	423..430	CDD:409353	3/6 (50%)
		Ig strand C	437..442	CDD:409353	2/4 (50%)
		Ig strand C'	444..447	CDD:409353	0/2 (0%)
		Ig strand D	455..462	CDD:409353	1/6 (17%)
		Ig strand E	472..479	CDD:409353	2/11 (18%)
		Ig strand F	490..497	CDD:409353	0/6 (0%)
		Ig strand G	500..507	CDD:409353	2/6 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910