DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15864 and P4HA2

DIOPT Version :9

Sequence 1:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001136071.1	Gene:	P4HA2 / 8974	HGNCID:	8547	Length:	535	Species:	Homo sapiens

Alignment Length:	540	Identity:	144/540 - (26%)
Similarity:	240/540 - (44%)	Gaps:	110/540 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VKSNPKKSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSRENMEMKSDYESY 88
            |.|..:..:..|...:..|:..|.|||.:||.|:...:.|.:.::.....|.....:..:|.|.|
Human    15 VLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGY 79

  Fly    89 LGNPLNSFRLIHRLHTSWRKWYQYAIKVENNALGHIENARLMRKMLPTSSDLQQACRGIHDLMSF 153
            |.:|:|:::|:.||:|.|.....  :.::::|.|.|.|..:.|:..||..|...|.:.:..|...
Human    80 LAHPVNAYKLVKRLNTDWPALED--LVLQDSAAGFIANLSVQRQFFPTDEDEIGAAKALMRLQDT 142

  Fly   154 YDLKPEELAAGNLAGYSQPGTG----LTAYDCLALGEFS---------------VQKREDDLAEA 199
            |.|.|..::.|.|     |||.    |:..||..:|..:               |.|:.|...||
Human   143 YRLDPGTISRGEL-----PGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEA 202

  Fly   200 WYNLSLIRFENKFDKYR---VHKAWGL-----------------------LLAKNKQLTDAFYHF 238
            ....|.:.....:..::   :|:|..|                       ||.:.::.|     .
Human   203 TTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRYFEQLLEEEREKT-----L 262

  Fly   239 ENKPEGIIASNEVIHFK-----------EELSTKQNCAVVVQKPSRLHCRY-NTTTTPFTRIAPL 291
            .|:.|..:|:.|.|:.:           |.|...:...:..::..||.||| :....|...|||.
Human   263 TNQTEAELATPEGIYERPVDYLPERDVYESLCRGEGVKLTPRRQKRLFCRYHHGNRAPQLLIAPF 327

  Fly   292 KMEELGLDPYMVVFHDVIYDTEID--------------------GMLNSSNFGLSLTDSGQKSEV 336
            |.|:....|::|.::||:.|.||:                    |:|..:::
Human   328 KEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASY------------- 379

  Fly   337 RTSKDSYIVD-----AKTLNERVTDMTGFSMEMSDPFSLINYGLGGHYMLHYDFHEYTNTTRPKQ 396
            |.||.|::.:     ...:|.|:..:||.:::.::...:.|||:||.|..|:||.........|.
Human   380 RVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDERDTFKH 444

  Fly   397 ---GDRIATVLFYLGEVDSGGATIFPMINITVTPKKGSAVFWYNLHNSGAMNLKSLHSACPVISG 458
               |:|:||.|.|:.:|::||||:||.:...:.||||:|||||||..||..:.::.|:||||:.|
Human   445 LGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVG 509

  Fly   459 SKYVLTKWINELPQMFVTPC 478
            .|:|..||.:|..|.|:.||
Human   510 CKWVSNKWFHERGQEFLRPC 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	36/130 (28%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	20/80 (25%)
		P4Hc	313..467	CDD:214780	57/181 (31%)
P4HA2	NP_001136071.1	P4Ha_N	26..155	CDD:311993	36/130 (28%)
		TPR	207..240		4/32 (13%)
		P4Hc	346..519	CDD:214780	59/185 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020