DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15864 and P4ha1

DIOPT Version :9

Sequence 1:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_742059.2	Gene:	P4ha1 / 64475	RGDID:	621000	Length:	534	Species:	Rattus norvegicus

Alignment Length:	518	Identity:	146/518 - (28%)
Similarity:	245/518 - (47%)	Gaps:	81/518 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 YAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSRENMEMKSDYESYLGNPLNSF 96
            :..|..::..|:..|.:||.:||.|:|..:.|...:::....:.|.......|.|.::|:|:|:|
  Rat    21 FFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAF 85

  Fly    97 RLIHRLHTSWRKWYQYAIKVENNALGHIENARLMRKMLPTSSDLQQACRGIHDLMSFYDLKPEEL 161
            :|:.||:|.|.:.....:|..::  |.|.|..:.|:..|...|...|.:.:..|...|:|....:
  Rat    86 KLMKRLNTEWSELENLILKDMSD--GFISNLTIQRQYFPNDEDQVGAAKALFRLQDTYNLDTNTI 148

  Fly   162 AAGNLAGYSQPGTGLTAYDCLALGEFSVQKREDDLAEAWYNLSLIRFE----NKFDK-------- 214
            :.|||.|.... :.|||.||..||:.:..:.:....|.|...:|::.|    :..||
  Rat   149 SKGNLPGVKHK-SFLTAEDCFELGKVAYTEADYYHTELWMEQALMQLEEGEMSTVDKVSVLDYLS 212

  Fly   215 YRVHKAWGL---LLAKNKQLTDAFYHFENKPEGIIASNEVIHFK------------------EEL 258
            |.|::...|   ||...|.|       |..||...|:..:::|:                  ::.
  Rat   213 YAVYQQGDLDKALLLTKKLL-------ELDPEHQRANGNLVYFEYIMSKEKDANKSASGDQSDQK 270

  Fly   259 STKQNCAVVV----------------------QKPSRLHCRYNT-TTTPFTRIAPLKMEELGLDP 300
            :|.:...:.|                      ::..||.|||:. ...|...:||.|.|:....|
  Rat   271 TTPKKKGIAVDYLPERQKYEMLCRGEGIKMTPRRQKRLFCRYHDGNRNPKFILAPAKQEDEWDKP 335

  Fly   301 YMVVFHDVIYDTEIDGMLNSSNFGLSLT-----DSGQ--KSEVRTSKDSYIVD-----AKTLNER 353
            .::.|||:|.|.||:.:.:.:...||..     ::|:  .::.|.||.:::..     ...:|.|
  Rat   336 RIIRFHDIISDAEIEIVKDLAKPRLSRATVHDPETGKLTTAQYRVSKSAWLSGYEDPVVSRINMR 400

  Fly   354 VTDMTGFSMEMSDPFSLINYGLGGHYMLHYDFHEYTNTTRPKQ---GDRIATVLFYLGEVDSGGA 415
            :.|:||..:..::...:.|||:||.|..|:||.........::   |:||||.|||:.:|.:|||
  Rat   401 IQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFRELGTGNRIATWLFYMSDVSAGGA 465

  Fly   416 TIFPMINITVTPKKGSAVFWYNLHNSGAMNLKSLHSACPVISGSKYVLTKWINELPQMFVTPC 478
            |:||.:..:|.||||:|||||||..||..:..:.|:||||:.|:|:|..||::|..|.|..||
  Rat   466 TVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPC 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	34/130 (26%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	18/109 (17%)
		P4Hc	313..467	CDD:214780	60/168 (36%)
P4ha1	NP_742059.2	P4Ha_N	25..112	CDD:400573	23/88 (26%)
		TPR	205..238		9/39 (23%)
		P4Hc	345..518	CDD:214780	62/172 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920