DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15864 and zgc:152670

DIOPT Version :9

Sequence 1:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001070123.2	Gene:	zgc:152670 / 557059	ZFINID:	ZDB-GENE-060929-954	Length:	490	Species:	Danio rerio

Alignment Length:	533	Identity:	153/533 - (28%)
Similarity:	246/533 - (46%)	Gaps:	109/533 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LKNLTLIGFLSACFINCQGFVKSNPKKSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLME 68
            :|.|||       |:.|..|| |..::.:.:|..::.:|...|:.|:|....|:...:.....|:
Zfish     3 MKELTL-------FVVCSWFV-SITEQEFFSSVDQVSQLFNEEENLLDTFSLYIDAEEENLKKMK 59

  Fly    69 RSLIDMSRENMEMKSDYESYLGNPLNSFRLIHRLHTSW---RKWYQYAIKVENNALGHIENARLM 130
            ..|:.:...:.......|..:.:|:.:|:|:.||...|   .|:.|.::..|...|       |.
Zfish    60 SLLLLLQLGSFSNPQSPEETMRDPVAAFKLLKRLRHEWVNIAKFTQQSLYQEFQTL-------LD 117

  Fly   131 RKMLPTSSDLQQACRGIHDLMSFYDLKPEELA-----AGNLAGYSQPGTGLTAYDCLALGEFSVQ 190
            ..::|...|:..|..|:..|...|.|.|..:.     :.:.|.|    .||.||:
Zfish   118 YSLIPELEDINSAALGLIGLQEIYKLYPHNITKETPLSADEAYY----IGLVAYE---------- 168

  Fly   191 KREDDLAEA--WYNLSLIRFEN-----KFDKYRVHKAWGLLLAKNKQLTDAFYHFENKPEGIIAS 248
              ||....|  |:..||.|..:     |.|..|.             |:.:.|.|.:.|..|...
Zfish   169 --EDKFQHAFLWFLHSLNRLTDFSSTTKNDLLRF-------------LSSSAYQFGSLPVAIYFG 218

  Fly   249 NEVIHF---KEE-----------------------LSTKQN------C-AVVVQKPSR----LHC 276
            .::::.   .||                       |:|:.|      | ..|.::.|:    |.|
Zfish   219 QKLLNLDPSNEEIKVQLGLYRLIRLQRTSNPDIFTLNTQSNNSYEALCRGEVDERTSKRQRALSC 283

  Fly   277 RYNT-TTTPFTRIAPLKMEELGLDPYMVVFHDVIYDTEIDGMLNSSNFGL--SLTDSGQKSEVRT 338
            ||:| ...|....||:|.|||..:|.::.:||||.||||:.:.:.:...|  |.|..|..|::||
Zfish   284 RYSTGGGNPRLMYAPVKEEELWDEPKIIRYHDVISDTEIETLKDIARPELTRSQTGWGVISDIRT 348

  Fly   339 SKDSYIVDAKT---LNERVTDMTGFSMEMSDPFSLINYGLGGHYMLHYDFHEYTNTTRPKQGDRI 400
            |:..::.:..|   :::|:.|:||.|:|.::...:.|||:||.|..|:|..:..|       :|.
Zfish   349 SQSVFLEEVGTVARISQRIADITGLSVESAEKLHVQNYGIGGRYTPHFDTGDEVN-------ERT 406

  Fly   401 ATVLFYLGEVDSGGATIFPMINITVTPKKGSAVFWYNLHNSGAMNLKSLHSACPVISGSKYVLTK 465
            ||.|.|:.:|:.||||:|..:.:.|.|:|||||||||||.:|.::||:.|:.|||:.|:|:|..|
Zfish   407 ATFLIYMSDVEVGGATVFTNVGVAVKPEKGSAVFWYNLHKNGELDLKTKHAGCPVLVGNKWVANK 471

  Fly   466 WINELPQMFVTPC 478
            ||:|..|.|..||
Zfish   472 WIHEFGQEFRRPC 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	28/138 (20%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	24/106 (23%)
		P4Hc	313..467	CDD:214780	61/158 (39%)
zgc:152670	NP_001070123.2	P4Ha_N	26..150	CDD:285528	28/130 (22%)
zgc:152670	NP_001070123.2	P4Hc	318..474	CDD:214780	64/162 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920