DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15864 and P4HTM

DIOPT Version :9

Sequence 1:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_808807.2	Gene:	P4HTM / 54681	HGNCID:	28858	Length:	563	Species:	Homo sapiens

Alignment Length:	287	Identity:	65/287 - (22%)
Similarity:	93/287 - (32%)	Gaps:	126/287 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 DTEIDGMLNSSNF-GLSLTD--------SGQKSE-VRTSKDSYIVDA-------KTLNERVTDMT 358
            |.:.||:|:...| .:.|.|        ..:.|| ||.|..:::...       :.:.:||..:|
Human   237 DPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRLT 301

  Fly   359 GFS---MEMSDPFSLINYGLGGHYMLHYD----------------------FHEYTNTTRPK--- 395
            ..|   :|:|:|..::.||.||||..|.|                      |........|.
Human   302 RLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRQVSPNWGL 366

  Fly   396 -------------------------QGDR------------------------IATVLFYLGEVD 411
                                     .||.                        ..||||||..|.
Human   367 PSILRPGTPMTQAQPCTVGVPLGMGPGDHWVIPVSPWEHPQLGTCSVPPLPYSYMTVLFYLNNVT 431

  Fly   412 SGGATIFPMI---------------------------NITVTPKKGSAVFWYNLHNSGA-----M 444
            .||.|:||:.                           |:.|.|::|:||||||....|.     :
Human   432 GGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDV 496

  Fly   445 NLKSLHSACPVISGSKYVLTKWINELP 471
            :..|||..|.|..|:|::...|||..|
Human   497 DDYSLHGGCLVTRGTKWIANNWINVDP 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528
		metallo-dependent_hydrolases	<237..>306	CDD:294200
		P4Hc	313..467	CDD:214780	60/279 (22%)
P4HTM	NP_808807.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..111
		EF-hand_7	192..252	CDD:290234	5/14 (36%)
		EFh	194..252	CDD:238008	5/14 (36%)
		P4Hc	246..519	CDD:214780	57/272 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149313
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740