DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15864 and PH4alphaMP

DIOPT Version :9

Sequence 1:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_524594.2	Gene:	PH4alphaMP / 43624	FlyBaseID:	FBgn0026190	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	147/533 - (27%)
Similarity:	239/533 - (44%)	Gaps:	88/533 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FLSACFINCQGFVKSNPKKSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSR 76
            ||....::|.|        .:.:||..|.||.|.|..|:..|:.||..:......::..:..:..
  Fly     9 FLVLQVLSCHG--------EFFSSTSGLAKLFETEVVLLAELQNYVNEINQHAEALQSEIDAIRV 65

  Fly    77 ENMEMKSDYESYLGNPLNSFRLIHRLHTSWRKWYQYAIKVENNALGHIENARLMRKML--PTSSD 139
            |::......:.||.||:|:||||.|||:.| :.::.::..:::...:::....:::.|  |:..|
  Fly    66 EHLNAADGIDDYLNNPVNAFRLIKRLHSDW-ETFEGSVTADSSRSNYLDTMASLKENLSFPSQDD 129

  Fly   140 LQQACRGIHDLMSFYDLKPEELAAGNLAGYSQPGTGLTAYDCLALGEFSVQKREDDLAEAWYNLS 204
            ...:...:..|...|.|...|||:|.|.|... ||.::..||..||:.....|:.:....|...|
  Fly   130 FVGSAIALTRLQQTYQLDVAELASGILNGVKY-GTAMSWQDCFVLGQHLYALRDYNHTVPWLQQS 193

  Fly   205 L--------------IRFENKFDKYRVHKAWGL---------------------LLAKNKQL--- 231
            :              :.|.....:|  |:..|.                     ||...:||
  Fly   194 MQLLGEQSYGSESASLDFMEAVVEY--HREMGAHESALSLVNHVLSIEPDQRSHLLEARQQLEEL 256

  Fly   232 -TD----AFYHFENKPEGIIASNEVIHFKEELSTKQNCAVVVQKPSRLHCRYNTTTTPFTRIAPL 291
             ||    ...|...:..|....:......|:: .:...|.:..|...|.||...:...:   ||.
  Fly   257 ITDGDKNGLLHLTARRPGDYHESREFRMYEQV-CRGELAPLPSKQRNLRCRLRKSRLGY---APF 317

  Fly   292 KMEELGLDPYMVVFHDVIYDTEIDGM--------LNSSNFGLSLTDSGQKSEVRTSKD---SYIV 345
            |:|||.|||.:|..|.||...:.|.:        ..|:.:.|........:..|||:.   :|..
  Fly   318 KLEELHLDPLVVQLHQVIGSKDSDSLQKTARPRIKRSTVYSLGGNGGSTAAAFRTSQGASFNYSR 382

  Fly   346 DA--KTLNERVTDMTGFSMEMSDPFSLINYGLGGHYMLHYDF----HEYTNTTRPKQGD----RI 400
            :|  |.|:..|.|.:|.:|:.::...:.|||:||||..|:|.    |.|      ::||    |:
  Fly   383 NAATKLLSRHVGDFSGLNMDYAEDLQVANYGIGGHYEPHWDSFPENHIY------QEGDLHGNRM 441

  Fly   401 ATVLFYLGEVDSGGATIFPMINITVTPKKGSAVFWYNLHNSGAMNLKSLHSACPVISGSKYVLTK 465
            ||.::||.:|::||.|.||.:.:.|||::||.:||||||.||..:.::.|:||||:.|||::...
  Fly   442 ATGIYYLADVEAGGGTAFPFLPLLVTPERGSLLFWYNLHPSGDQDFRTKHAACPVLQGSKWIANV 506

  Fly   466 WINELPQMFVTPC 478
            ||.|..|..|.||
  Fly   507 WIRERNQDNVRPC 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	35/132 (27%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	18/68 (26%)
		P4Hc	313..467	CDD:214780	59/174 (34%)
PH4alphaMP	NP_524594.2	P4Ha_N	24..156	CDD:285528	35/132 (27%)
PH4alphaMP	NP_524594.2	P4Hc	336..509	CDD:214780	60/178 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461826
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900