DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15864 and PH4alphaSG2

DIOPT Version :9

Sequence 1:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_651801.1	Gene:	PH4alphaSG2 / 43623	FlyBaseID:	FBgn0039779	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	137/530 - (25%)
Similarity:	234/530 - (44%)	Gaps:	124/530 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 YAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSREN----MEMKSDYESYLGNP 92
            :.:|...:..|.:||:||::..:.||::.:.:.:...|.:..:.||:    .::|.|  .|||:|
  Fly    25 FYSSVDSMQDLAQVEEELLNATRSYVESQQKQLDFYRRYVEQIKREHEWATSQLKLD--DYLGHP 87

  Fly    93 LNSFRLIHRLHTSW-------------RKWYQYAIKVENNALGHIENARLMRKMLPTSSDLQQAC 144
            |::||||.||...|             |:.::..::|.:..||:           |..|:||.|.
  Fly    88 LHAFRLIKRLVRDWDSLIFEPILANNAREEFRAFVEVLSRDLGY-----------PDQSELQGAI 141

  Fly   145 RGIHDLMSFYDLKPEELAAGNLAGYSQPGTGLTAYDCLALGEFSVQKREDDLAEAWYNLSLI--- 206
            :|:..|...|:|...:||.|.:.|.:. |:.|...:|..:|.......|...:..|..::.|
  Fly   142 KGLARLQKVYNLATSDLADGIIGGLNY-GSDLRWRECYEIGVQLFDLGEYQRSLEWLQVAFILLR 205

  Fly   207 ---RFENKFDKYRVHKAWGLLLAKNKQLTD-------AFYHFENKPEGIIASNEVIHFKEELSTK 261
               |.|...|.|               |:|       |.:...|..:.....::::..:...|.:
  Fly   206 NSPREEKDADHY---------------LSDIREYASMANFELGNPKKAARLLSQILESQPTHSAQ 255

  Fly   262 QNCAVV--------VQ--KPS---------------------RLHCRYNTTTTPFTRIAPLKMEE 295
            |....:        ||  |||                     .|.|..:.....:..:|||::|.
  Fly   256 QTQKYLESRVPGKNVQETKPSWFSNYTRLCQGRRLPEERSGDPLRCYLDGKRHAYFTLAPLQVEP 320

  Fly   296 LGLDPYMVVFHDVIYDTEIDGMLNSSNFGLSLTDSGQKSE-----------------VRTSKDSY 343
            :.|||.:.|:|         |||:|... ||:.:...|.|                 :|.|:.::
  Fly   321 VHLDPDINVYH---------GMLSSKQI-LSIFEEADKEEMVRSAVAGSGGEGTVRDLRVSQQTW 375

  Fly   344 IVDAK-----TLNERVTDMTGFSMEMSDPFSLINYGLGGHYMLHYDFHEYTNTTRPKQGDRIATV 403
            : |.|     ::...:..::||.|..::...:.|||:||.|..|.|:.| .|..:..:||||:|.
  Fly   376 L-DYKSPVMNSVGRIIQFVSGFDMAGAEHMQVANYGVGGQYEPHPDYFE-VNLPKNFEGDRISTS 438

  Fly   404 LFYLGEVDSGGATIFPMINITVTPKKGSAVFWYNLHNSGAMNLKSLHSACPVISGSKYVLTKWIN 468
            :|||.:|:.||.|:|..:|:.:.|.||:.|.|:|||.|..::.::||:.||||.|||.:...|::
  Fly   439 MFYLSDVEQGGYTVFTKLNVFLPPVKGALVMWHNLHRSLHVDARTLHAGCPVIVGSKRIGNIWMH 503

  Fly   469 ELPQMFVTPC 478
            ...|.|..||
  Fly   504 SGYQEFRRPC 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	41/147 (28%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	18/99 (18%)
		P4Hc	313..467	CDD:214780	57/175 (33%)
PH4alphaSG2	NP_651801.1	P4Ha_N	28..163	CDD:285528	41/147 (28%)
PH4alphaSG2	NP_651801.1	P4Hc	335..503	CDD:214780	55/170 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461782
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900