DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15864 and p4ha2

DIOPT Version :9

Sequence 1:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	XP_005173949.1	Gene:	p4ha2 / 373132	ZFINID:	ZDB-GENE-030827-1	Length:	542	Species:	Danio rerio

Alignment Length:	539	Identity:	142/539 - (26%)
Similarity:	245/539 - (45%)	Gaps:	103/539 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SNPKKSYAASTM-ELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSRENMEMKSDYESYL 89
            |:|.::...::: ::..|:..|.|||.:||.|::..:.|...:......:.:......||.|.:|
Zfish    15 SSPTRAEIFTSIGQMTNLIFTERELVQSLKEYIQAEEQKLETVRSWANKLDKLTRTSTSDPEGFL 79

  Fly    90 GNPLNSFRLIHRLHTSWRKWYQYAIKVENNALGHIENARLMRKMLPTSSDLQQACRGIHDLMSFY 154
            .:|:|:::|:.||:|.|.:  ..::.:::.:.|.|.|..:.|:..|...|.:.|.:.:..|...|
Zfish    80 AHPVNAYKLMKRLNTEWSE--LESLVLQDPSDGFISNMSVHRQYFPDEEDEKGAAKALLRLQDTY 142

  Fly   155 DLKPEELAAGNLAGYSQPGTG------LTAYDCLALGEFSVQKREDDLAEAWYNLSLIRFEN--- 210
            .|..|..:.|.|.|..| .:|      ||..||..:|:.:....:...:..|...||.:.::
Zfish   143 KLDAESFSKGKLPGQRQ-HSGVRYNALLTVDDCFDMGKMAYNDNDYYHSVLWMQQSLRQMDSGEE 206

  Fly   211 ----KFD-----KYRVHKAWGL---------LLA------------------KNKQLTDA----- 234
                |.|     .|.|::...|         |||                  .:|:|.|:
Zfish   207 AKTPKADVLDYLSYSVYQMGDLPRAIELTRRLLAIDPSHQRAGGNLRYFERLLSKELQDSGQTQP 271

  Fly   235 -----------FYHFENKPEGIIASNEVIHFKEELSTKQNCAVVVQKPSRLHCRY-NTTTTPFTR 287
                       .|   .:|:..:...|..   |.|...:...:..::.|||.||| :....|...
Zfish   272 EPADERPIQLDTY---QRPKDYLPEREAY---EALCRGEGVKMTTKRQSRLFCRYRDGNRNPRLL 330

  Fly   288 IAPLKMEELGLDPYMVVFHDVIYDTEID--------------------GMLNSSNFGLSLTDSGQ 332
            :.|:|.|:....|::|.|.:.:.|.||.                    |:|..:::.:|
Zfish   331 LKPMKEEDEWDSPHIVRFLEALSDEEIQKIKEIATPKLARATVRDPKTGVLTVAHYRVS------ 389

  Fly   333 KSEVRTSKDSYIVDAKTLNERVTDMTGFSMEMSDPFSLINYGLGGHYMLHYDFHEYTNTTRPKQ- 396
            ||.....:|..::  ..:|:|:.|:||.:::.::...:.|||:||.|..|:||.........|.
Zfish   390 KSAWLEGEDDPVI--ARVNQRIEDITGLTVDTAELLQVANYGVGGQYEPHFDFSRKDEPDAFKSL 452

  Fly   397 --GDRIATVLFYLGEVDSGGATIFPMINITVTPKKGSAVFWYNLHNSGAMNLKSLHSACPVISGS 459
              |:|:||.|.|:.:|::||||:||....:|.|:||:|||||||..||..:.::.|:||||:.||
Zfish   453 GTGNRVATYLNYMSDVEAGGATVFPDFGASVWPRKGTAVFWYNLFRSGEGDYRTRHAACPVLVGS 517

  Fly   460 KYVLTKWINELPQMFVTPC 478
            |:|..|||:|..|.|..||
Zfish   518 KWVSNKWIHERGQEFRRPC 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	32/131 (24%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	16/69 (23%)
		P4Hc	313..467	CDD:214780	59/176 (34%)
p4ha2	XP_005173949.1	P4Ha_N	25..154	CDD:285528	32/130 (25%)
p4ha2	XP_005173949.1	P4Hc	353..526	CDD:214780	61/180 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920