DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15864 and P4ha3

DIOPT Version :9

Sequence 1:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	XP_038938408.1	Gene:	P4ha3 / 361612	RGDID:	735150	Length:	549	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	141/552 - (25%)
Similarity:	224/552 - (40%)	Gaps:	155/552 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SYAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSR---ENMEMKSDYESYLGNP 92
            :::|.| .:.:.|..|..|:..|:.|::.       .|..|.|::|   :.:.:..|.:..:.||
  Rat    30 TFSALT-SVARALAPERRLLGTLRRYLRG-------EEARLRDLTRFYDKVLSLHEDLKIPVVNP 86

  Fly    93 LNSFRLIHRLHTSWRKWYQYAIKVENNALGHIENARLMR-------KMLPTSSDLQQACRGIHDL 150
            |.:|.||.||.:.||...        ::|...||.|.::       :.||...||:.|.|.:..|
  Rat    87 LLAFTLIKRLQSDWRNVV--------HSLEATENIRALKDGYEKVEQDLPAFEDLEGAARALMRL 143

  Fly   151 MSFYDLKPEELAAGNLAGYSQPGTG--------------LTAYDCLALG---------------- 185
            ...|.|..:.||    .|..|..||              |||.||..:|
  Rat   144 QDVYMLNVKGLA----QGVFQRVTGSSITDLYSPRQLFSLTADDCFQVGKVAYDTGDYYHAIPWL 204

  Fly   186 ------------------EFSVQKREDDLAEAWYN-------LSLIRF------ENKFDKYRVHK 219
                              |.|::...|.||.|.|.       |||.|.      :||.....|.|
  Rat   205 EEAVSLFRRSYGEWKTEDEASLEDALDYLAFACYQVGNVSCALSLSREFLVYSPDNKRMARNVLK 269

  Fly   220 AWGLLLAKNKQLTDAFYHFENKPEGIIASNEVIHFKEELSTKQNCAVVVQKPSR-----LHCRYN 279
             :..|||:|..|..|        |..|....|.|.:...:.:..|..:..:|:.     |:|.|.
  Rat   270 -YERLLAENGHLMAA--------ETAIQRPNVPHLQTRDTYEGLCQTLGSQPTHYQIPSLYCSYE 325

  Fly   280 TTTTPFTRIAPLKMEELGLDPYMVVFHDVIYDTEIDGMLNSSNFGL--SLTDSGQKS---EVRTS 339
            |.::|:..:.|.:.|.:.|.|.:.::||.:.|.|...:...:...|  |:..||:|.   |.|.|
  Rat   326 TNSSPYLLLQPARKEVIHLRPLVALYHDFVSDEEAQKIRELAEPWLQRSVVASGEKQLQVEYRIS 390

  Fly   340 KDSYIVDA-----KTLNERVTDMTGFSMEMSDPFS----LINYGLGGHYMLHYDFHEYTNTTRP- 394
            |.:::.|.     .||:.|:..:||  :::..|::    ::|||:||||..|:|  ..|:.:.|
  Rat   391 KSAWLKDTVDPVLVTLDRRIAALTG--LDIQPPYAEYLQVVNYGIGGHYEPHFD--HATSPSSPL 451

  Fly   395 ---KQGDRIATVLFYLGEVDSGGATIFPMINITVTPKKGSAVFWYNLHNSG--AMNLKSLHSACP 454
               |.|:|:||::.||..|::||||.|...|.:|     ..|.|   ..||  :|:..|...|.|
  Rat   452 YKMKSGNRVATLMIYLSSVEAGGATAFIYGNFSV-----PVVKW---PTSGYTSMDRNSEDPAAP 508

  Fly   455 VISGSKYVLTKWINELPQMFVTPCMKDSNLHP 486
            ::.                  |..:.|.:|.|
  Rat   509 ILK------------------TETLADGSLSP 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	36/140 (26%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	15/73 (21%)
		P4Hc	313..467	CDD:214780	51/173 (29%)
P4ha3	XP_038938408.1	P4Ha_N	34..108	CDD:400573	21/89 (24%)
P4ha3	XP_038938408.1	P4Hc	356..>478	CDD:214780	41/125 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343160
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750