DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15864 and P4ha2

DIOPT Version :9

Sequence 1:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001101745.1	Gene:	P4ha2 / 360526	RGDID:	1309673	Length:	535	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	143/527 - (27%)
Similarity:	242/527 - (45%)	Gaps:	100/527 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 YAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSRENMEMKSDYESYLGNPLNSF 96
            :..|...:..|:..|.:||.:||.|:...:.|.:.::.....|.....:..:|.|.||.:|:|::
  Rat    23 FFTSIGHMTDLIYAEKDLVQSLKEYILAEEAKLSKIKSWASKMEALTSKSAADPEGYLAHPVNAY 87

  Fly    97 RLIHRLHTSWRKWYQYAIKVENNALGHIENARLMRKMLPTSSDLQQACRGIHDLMSFYDLKPEEL 161
            :|:.||:|.|.....  :.:::.|.|.:.|..:.|:..||..|...|.|.:..|...|.|.|:.:
  Rat    88 KLVKRLNTDWPALGD--LVLQDAAAGFVANLSVQRQFFPTDEDESGAARALMRLQDTYKLDPDMI 150

  Fly   162 AAGNLAGYSQPGTG----LTAYDCLALGEFS---------------VQKREDDLAEAWYNLSLIR 207
            :.|.|     |||.    |:..||..:|..:               |.|:.|...||....||:.
  Rat   151 SRGEL-----PGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATVTKSLVL 210

  Fly   208 FENKFDKYR---VHKAWGL---LLA---KNKQLTDAFYHFE------------NKPEGIIASNEV 251
            ....:..::   :|:|..|   ||:   .:::......:||            |:.:..:||.|.
  Rat   211 DYLSYAVFQLGDLHRAVELTRRLLSLDPSHERAGGNLRYFERLLEEERGKSLSNQTDAGLASQEN 275

  Fly   252 IHFK-----------EELSTKQNCAVVVQKPSRLHCRY-NTTTTPFTRIAPLKMEELGLDPYMVV 304
            ::.:           |.|...:...:..::..||.||| :....|...|||.|.|:....|::|.
  Rat   276 LYERPVDYLPERDVYESLCRGEGIKMTPRRQKRLFCRYHHGNRVPQLLIAPFKEEDEWDSPHIVR 340

  Fly   305 FHDVIYDTEID--------------------GMLNSSNFGLSLTDSGQKSEVRTSKDSYIVD--- 346
            ::||:.|.||:                    |:|..:::             |.||.|::.:
  Rat   341 YYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASY-------------RVSKSSWLEEDDD 392

  Fly   347 --AKTLNERVTDMTGFSMEMSDPFSLINYGLGGHYMLHYDF---HEYTNTTRPKQGDRIATVLFY 406
              ...:|.|:..:||.:::.::...:.|||:||.|..|:||   .|.....|...|:|:||.|.|
  Rat   393 PVVARVNRRMQHITGLTVKTAELLQVANYGMGGQYEPHFDFSRSDERDAFKRLGTGNRVATFLNY 457

  Fly   407 LGEVDSGGATIFPMINITVTPKKGSAVFWYNLHNSGAMNLKSLHSACPVISGSKYVLTKWINELP 471
            :.:|::||||:||.:...:.||||:|||||||..||..:.::.|:||||:.|.|:|..||.:|..
  Rat   458 MSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERG 522

  Fly   472 QMFVTPC 478
            |.|:.||
  Rat   523 QEFLRPC 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	35/130 (27%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	21/92 (23%)
		P4Hc	313..467	CDD:214780	58/181 (32%)
P4ha2	NP_001101745.1	P4Ha_N	27..104	CDD:400573	20/78 (26%)
P4ha2	NP_001101745.1	P4Hc	346..519	CDD:214780	60/185 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920