DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15864 and CG31013

DIOPT Version :9

Sequence 1:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	175/513 - (34%)
Similarity:	270/513 - (52%)	Gaps:	75/513 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KKSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSRENMEMKSDYESYLGNPL 93
            :||::.|.:.::.|||:|.:|:|||:.|...|:.|..::...|:.:..||.:.:.:..|||.|||
  Fly    25 EKSHSLSLVTMVPLLELEKKLIDNLENYTNALEQKLEIIRSQLLVIRAENEKGRRNAISYLSNPL 89

  Fly    94 NSFRLIHRLHTSWRKWYQYAIKVENNALGHIENARLMRKMLPTSSDLQQACRGIHDLMSFYDLKP 158
            |.|.:|.|||..|..|.:|  ..:...:..::.....:..|||..||..||.||..:.|.||||.
  Fly    90 NGFSIIRRLHQDWINWRKY--MEQPVGIWQLKAFYSWKDELPTERDLWDACEGIARIQSTYDLKV 152

  Fly   159 EELAAGNLAGYSQPGTGLTAYDCLALGEFSVQK------------------------------RE 193
            .:...||:.| .|....::..|.|::|.:...|                              :|
  Fly   153 GDFINGNING-KQYNDSMSTADILSVGAYLFMKNRPSDAIQWLQEVPQRLQEELLIQPRHLPIKE 216

  Fly   194 DD----LAEAW-----YNLSLIRFEN--KFDKY--RVHKAWGLLLAKNKQLTDAFYHFENKPEGI 245
            .|    ||||.     |:.:|....|  |...:  ||.:.|       |:.||   ..||:|:..
  Fly   217 VDALRLLAEAQIKDQNYSEALPLLHNCLKLQPHDARVLRLW-------KKTTD---FIENQPDQS 271

  Fly   246 IASNEVIHFKEELSTKQNCAVVVQKPSRLHCRYNTTTTPFTRIAPLKMEELGLDPYMVVFHDVIY 310
            ...|:..:.....:.|.:|...::..:||||.||.|||||.|:||||.|::|||||:|::|:|:.
  Fly   272 PTENKKRNVPIANAFKLSCNGPLESSTRLHCFYNFTTTPFLRLAPLKTEQIGLDPYVVLYHEVLS 336

  Fly   311 DTEIDGMLNSSNFGLSLTD------SGQKSEVRTSKDSYIVD-----AKTLNERVTDMTGFSMEM 364
            ..||..::..:...:..|.      ..:|:..||:|..::..     .|.:..|:.|||||.:..
  Fly   337 AREISMLIGKAAQNMKNTKIHKERAVPKKNRGRTAKGFWLKKESNELTKRITRRIMDMTGFDLAD 401

  Fly   365 SDPFSLINYGLGGHYMLHYDFHEYTNT----TRPKQ----GDRIATVLFYLGEVDSGGATIFPMI 421
            |:.|.:||||:||||.||.|:.::.::    ||.:.    |||||||||||.:|:.||||:|..:
  Fly   402 SEGFQVINYGIGGHYFLHMDYFDFASSNHTDTRSRYSIDLGDRIATVLFYLTDVEQGGATVFGDV 466

  Fly   422 NITVTPKKGSAVFWYNLHNSGAMNLKSLHSACPVISGSKYVLTKWINELPQMFVTPCM 479
            ...|:|:.|:|:|||||...|..:.::.|:|||||.|||:|:|:||.|..|:|:.||:
  Fly   467 GYYVSPQAGTAIFWYNLDTDGNGDPRTRHAACPVIVGSKWVMTEWIREKRQIFIRPCL 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	45/130 (35%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	29/68 (43%)
		P4Hc	313..467	CDD:214780	67/172 (39%)
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	45/130 (35%)
		TPR_11	178..248	CDD:290150	12/69 (17%)
		TPR repeat	211..246	CDD:276809	9/34 (26%)
		P4Hc	336..513	CDD:214780	68/176 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461731
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900