DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15864 and CG31524

DIOPT Version :9

Sequence 1:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_733379.2	Gene:	CG31524 / 318781	FlyBaseID:	FBgn0051524	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	166/537 - (30%)
Similarity:	269/537 - (50%)	Gaps:	74/537 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYILKNL-TLIGFLSACFINCQGFVKSNPKKSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKF 64
            |.:||.| .:|.|||.    ..|.:::...: :|.|.:.:..||.:||:||..|:||.:.|..|.
  Fly     1 MPVLKLLFVVIFFLSL----SMGQIEATQPR-FARSVVNMDDLLNMEDDLVSKLEGYAEKLSYKA 60

  Fly    65 NLMERSLIDMSRENMEMKSDYESYLGNPLNSFRLIHRLHTSWRKWYQYAIK-VENNALGH--IEN 126
            |.: |..|...||.::.....:|:  :..|.:..|..:...|..|.||..| |..:.|.:  ::|
  Fly    61 NTI-RWGIQQMREQLDKSKKEQSF--DLFNRYSFIRHMQADWLMWKQYLDKPVIRDELNYKQMDN 122

  Fly   127 ARLMRKMLPTSSDLQQACRGIHDLMSFYDLKPEELAAGNLAGYSQPGTGLTAYDCLALGEFSVQK 191
            .|     :|...||..|...|..:.:.|.:...::|.|.|.|. |..:.|:..||||:|...:.:
  Fly   123 LR-----MPQELDLFDASEAIRRMQATYAMLSNDIAEGFLDGV-QYTSKLSPIDCLAMGRHLMNQ 181

  Fly   192 REDDLAEAWY-----------------------------NLSLIRFENKFDKYRVHKAWGLLLAK 227
            ....:||.|.                             .|..:|||.:.::..: ||:...|..
  Fly   182 SRWTIAEQWILAGIKAQDRKGPQTEMILLRGPTKAELFRTLGKVRFERRNEEGAL-KAYQAALKH 245

  Fly   228 NKQLTDAFYHFENKPEGI--IASNEVIHFK-----EELSTKQNCAVVVQKP---SRLHCRYNTTT 282
            :....:.|..::|....:  ::.:|.|..:     ||:.....|:...:.|   :||:|.||..|
  Fly   246 SPHDLEIFQEYQNLKRRVLTLSPSEPIREEPNDDIEEMELPPCCSGRCEGPRKLNRLYCVYNCVT 310

  Fly   283 TPFTRIAPLKMEELGLDPYMVVFHDVIYDTEIDGMLNSSNFGLSL----TDSGQKSEV---RTSK 340
            .||.|:||:|.|.|.:||::::.||::...| ..::.||:....|    .::..:.|:   ||||
  Fly   311 APFLRLAPIKTEILSVDPFVILLHDMVSHKE-GALIRSSSKNQILPSETVNAANEFEIAKFRTSK 374

  Fly   341 ----DSYIVDAK-TLNERVTDMTGFSMEMSDPFSLINYGLGGHYMLHYDFHEYTNTTRPKQG--D 398
                ||...:|. .|.:|:.:.||..|:.|:||.:||||:||.:..|:| ....:..|...|  |
  Fly   375 SVWFDSDANEATLKLTQRLGEATGLDMKHSEPFQVINYGIGGVFESHFD-TSLADEDRFVNGYID 438

  Fly   399 RIATVLFYLGEVDSGGATIFPMINITVTPKKGSAVFWYNLHNSGAMNLKSLHSACPVISGSKYVL 463
            |:||.||||.:|..||||.||.:||||.||.|:.:.|||||..|.::::::|:.||||.|||:|:
  Fly   439 RLATTLFYLNDVPQGGATHFPGLNITVFPKFGTVLMWYNLHTEGMLHVRTMHTGCPVIVGSKWVV 503

  Fly   464 TKWINELPQMFVTPCMK 480
            :|||::..|.|..||::
  Fly   504 SKWIDDKGQEFRRPCLR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	37/133 (28%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	23/78 (29%)
		P4Hc	313..467	CDD:214780	68/167 (41%)
CG31524	NP_733379.2	P4Ha_N	31..157	CDD:285528	37/133 (28%)
		TPR_11	215..>259	CDD:290150	8/44 (18%)
		TPR_2	216..249	CDD:285020	7/33 (21%)
		P4Hc	340..507	CDD:214780	68/168 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461730
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900