DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15864 and dpy-18

DIOPT Version :9

Sequence 1:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_499464.1	Gene:	dpy-18 / 176569	WormBaseID:	WBGene00001077	Length:	559	Species:	Caenorhabditis elegans

Alignment Length:	519	Identity:	140/519 - (26%)
Similarity:	235/519 - (45%)	Gaps:	82/519 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 STMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSRENMEMKSDYESYLGNPLNSFRLI 99
            |..::..|||.|..:...|..|:...:.:...:::...:.|::|.....:....:.||:|:|.||
Worm    21 SIADMQNLLETERNIPKILDKYIHDEEERLVQLKKLSEEYSKKNEISIENGLKDITNPINAFLLI 85

  Fly   100 HRLHTSWRKWYQYAIKVENNALGHI-----ENARLMRKMLPTSSDLQQACRGIHDLMSFYDLKPE 159
            .|....|:   :...|:..|..|::     :::..:|  .||:.||..|..|:..|...|.|..:
Worm    86 KRKIFDWK---EIESKMNANKAGNVVSSITDDSYGVR--YPTADDLSGAAIGLLRLQDTYRLDTK 145

  Fly   160 ELAAGNLAGYSQPGT-GLTAYDCLALGEFS---------------VQKREDD------------- 195
            :||.|.:  |:..|. ..:|.||..:...:               .|:|..|
Worm   146 DLADGKI--YADQGNYTFSAKDCFEIARAAYNEHDFYHTVMWMEEAQRRLGDEVEPTVEVEDILE 208

  Fly   196 -LAEAWYNLSLIRFENKF--DKYRVHKA---------W--GLLLAKNKQLTDAFYHF----ENKP 242
             ||.|.|..:.::...|.  :.|:::..         |  .||..:..:.:|...:.    ..:|
Worm   209 YLAFALYKQNNLKHALKLTEELYKMNPTHPRAKGNVKWYEDLLEQEGVRRSDMRKNLPPIQNRRP 273

  Fly   243 EGIIASNEVIHFKEELSTKQNCAVVVQKP-SRLHCRYNTTTTPFTRIAPLKMEELGLDPYMVVFH 306
            :.::.:.|...::   :..:|...|.||. |||:|.|. ...||...||:|:|....:|..|:|.
Worm   274 DSVLGNTERTMYE---ALCRNEVPVSQKDISRLYCYYK-RDRPFLVYAPIKVEIKRFNPLAVLFK 334

  Fly   307 DVIYDTEIDGM-------LNSSNFGLSLTDSGQKSEVRTSKDSYIVD-----AKTLNERVTDMTG 359
            |||.|.|:..:       |..:....|:|.....:..|.||.:::.:     .:|:|:|:..||.
Worm   335 DVISDDEVAAIQELAKPKLARATVHDSVTGKLVTATYRISKSAWLKEWEGDVVETVNKRIGYMTN 399

  Fly   360 FSMEMSDPFSLINYGLGGHYMLHYDFHEYTNTTRPKQ----GDRIATVLFYLGEVDSGGATIFPM 420
            ..||.::...:.|||:||||..|:| |.....::..:    |:||||||||:.:...||.|:|..
Worm   400 LEMETAEELQIANYGIGGHYDPHFD-HAKKEESKSFESLGTGNRIATVLFYMSQPSHGGGTVFTE 463

  Fly   421 INITVTPKKGSAVFWYNLHNSGAMNLKSLHSACPVISGSKYVLTKWINELPQMFVTPC-MKDSN 483
            ...|:.|.|..|:|||||:..|..|..:.|:||||:.|.|:|..|||:|....|..|| :|.|:
Worm   464 AKSTILPTKNDALFWYNLYKQGDGNPDTRHAACPVLVGIKWVSNKWIHEKGNEFRRPCGLKSSD 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	33/135 (24%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	19/73 (26%)
		P4Hc	313..467	CDD:214780	57/169 (34%)
dpy-18	NP_499464.1	P4Ha_N	21..152	CDD:285528	33/135 (24%)
dpy-18	NP_499464.1	P4Hc	338..511	CDD:214780	59/173 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920