DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15864 and p4ha1

DIOPT Version :9

Sequence 1:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	XP_031761963.1	Gene:	p4ha1 / 100490484	XenbaseID:	XB-GENE-987760	Length:	526	Species:	Xenopus tropicalis

Alignment Length:	539	Identity:	156/539 - (28%)
Similarity:	244/539 - (45%)	Gaps:	92/539 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LTLIGFLSACFINCQGFVKSNPKKSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSL 71
            |.|:|..|....:            :..|...::.||..|.:||.:||.|:|..:.|...:::..
Frog     7 LPLLGLFSCAHAD------------FFTSIGHMIDLLNTEKDLVTSLKDYIKAEEQKLAQIKKWA 59

  Fly    72 IDMSRENMEMKSDYESYLGNPLNSFRLIHRLHTSWRKWYQYAIKVENNAL-----GHIENARLMR 131
            ..:.........|.|.|||:|:|:|:|:.||:|.|       :|:||..|     |.|.|..:.|
Frog    60 DKLDHLTDTATKDPEGYLGHPVNAFKLMKRLNTEW-------VKLENLILKDISDGFISNLTIQR 117

  Fly   132 KMLPTSSDLQQACRGIHDLMSFYDLKPEELAAGNLAGYSQPGTGLTAYDCLALGEFSVQKREDDL 196
            :..|...|...|.:.:..|...|:|..:.::.|||.|.... |.|||.||..||:.:....:...
Frog   118 QYFPNDEDQTGAAKALLRLQDTYNLDTDTISKGNLPGVKHK-TSLTAEDCFDLGKTAYTDADYYH 181

  Fly   197 AEAWYNLSLIRF----ENKFDK--------YRVHKAWGLLLAKNKQLTDAFYHFENKPEGIIASN 249
            .|.|...:|.:.    |:..||        |.|::...|    :|.||......|..||....:.
Frog   182 TELWMEQALSQLDAGEESSLDKVMVLDYLSYAVYQQGDL----DKALTLTKRSLELDPEHQRGNG 242

  Fly   250 EVIHFKEELSTKQNCA---------------------------------VVVQKPSRLHCRY-NT 280
            .:.|...:.|.|.:.:                                 :..::..||.||| :.
Frog   243 NLRHIMSKESNKSSSSPSEGAELRTRKGRPKDHLEKEKYEKLCRGEGVKMTSRRQKRLFCRYFDG 307

  Fly   281 TTTPFTRIAPLKMEELGLDPYMVVFHDVIYDTEIDGM-------LNSSNFGLSLTDSGQKSEVRT 338
            ...|...::|.|.|:....|.:|.:||:|.|.||..:       |..:.....:|...:.::.|.
Frog   308 KKDPLLILSPTKQEDEWDKPRIVRYHDIISDEEISKVKELAKPRLRRATISNPITGVLETAQYRI 372

  Fly   339 SKDSYI------VDAKTLNERVTDMTGFSMEMSDPFSLINYGLGGHYMLHYDF-HEYTNTTRPK- 395
            :|.:::      |.|: ||.|:..:||..|..::...:.|||:||.|..|:|| .:|......|
Frog   373 TKSAWLSGYEDPVVAR-LNRRIEGVTGLDMSTAEELQVANYGIGGQYEPHFDFLRKYEPDAFKKL 436

  Fly   396 -QGDRIATVLFYLGEVDSGGATIFPMINITVTPKKGSAVFWYNLHNSGAMNLKSLHSACPVISGS 459
             .|:|:||.|||:.:|::||||:||.:...|.||||:|||||||..||..:..:.|:||||:.|:
Frog   437 GTGNRVATWLFYMSDVEAGGATVFPEVGAAVYPKKGTAVFWYNLLESGEGDYSTRHAACPVLVGN 501

  Fly   460 KYVLTKWINELPQMFVTPC 478
            |:|..|||:|..|.|..||
Frog   502 KWVSNKWIHERGQEFRRPC 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	39/135 (29%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	17/102 (17%)
		P4Hc	313..467	CDD:214780	62/169 (37%)
p4ha1	XP_031761963.1	P4Ha_N	24..111	CDD:400573	28/93 (30%)
p4ha1	XP_031761963.1	P4Hc	337..510	CDD:214780	64/173 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110