DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15864 and p4ha1b

DIOPT Version :9

Sequence 1:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_999856.1	Gene:	p4ha1b / 100003675	ZFINID:	ZDB-GENE-030131-4089	Length:	536	Species:	Danio rerio

Alignment Length:	519	Identity:	148/519 - (28%)
Similarity:	237/519 - (45%)	Gaps:	81/519 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 YAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSRENMEMKSDYESYLGNPLNSF 96
            :..||.::..||..|.:||.:||.|:|..:.:...::.....:....:....|.|.:||:|:|:|
Zfish    21 FFTSTGQMTDLLYAEKDLVTSLKEYIKQEENRLEQVKEWADKLDSLTITATQDPEGFLGHPVNAF 85

  Fly    97 RLIHRLHTSWRKWYQYAIKVENNALGHIENARLMRKMLPTSSDLQQACRGIHDLMSFYDLKPEEL 161
            :|:.||::.|.......:|...|  |.|.|..:.|:..||..|...|.:.:..|...|.|....:
Zfish    86 KLMKRLNSEWSDLENLVLKDTTN--GFISNLTVQRQYFPTDEDQTGAAKALLRLQDTYQLSANAI 148

  Fly   162 AAGNLAGYSQPGTGLTAYDCLALGEFSVQKREDDLAEAWYNLSLIRF----ENKFDK-------- 214
            ::|:|.|.... :.:|..||..||:.:....:....|.|...:|.:.    |:..||
Zfish   149 SSGDLPGVVHK-SRMTVEDCYELGKIAYSDADYYHTELWMAQALSQLDEGEESPIDKVTVMDYLS 212

  Fly   215 YRVHKAW----GLLLAKNKQLTDAFYHFENKPEGII------------ASNEVIHFKEE------ 257
            |.:::..    .|.|.|.....|..:|..|   |.:            |.||.   |||
Zfish   213 YAIYQQGELDRALELTKRMLKLDPNHHRAN---GNLKYFEFQLEKQRKAENEK---KEEDQKRVL 271

  Fly   258 ----------------------LSTKQNCAVVVQKPSRLHCRY-NTTTTPFTRIAPLKMEELGLD 299
                                  |...:...:..::.|||.||| |....|...:||:|.|:....
Zfish   272 DKRDAQRKRSKDPLPERKKYERLCRGEGIKLTPRRQSRLFCRYSNNNRNPRLLLAPVKQEDEWDR 336

  Fly   300 PYMVVFHDVIYDTEIDGM-------LNSSNFGLSLTDSGQKSEVRTSKDSYI-----VDAKTLNE 352
            |.:|.:|::|.|:||:.:       |..:.....:|...:.:..|.||.:::     ...:.:|:
Zfish   337 PRIVRYHEIISDSEIETVKEMAKPRLRRATISNPITGVLETAPYRISKSAWLSGYEHSTIERINQ 401

  Fly   353 RVTDMTGFSMEMSDPFSLINYGLGGHYMLHYDFHEYTNTTRPKQ---GDRIATVLFYLGEVDSGG 414
            |:.|:||..|:.::...:.|||:||.|..|:||.........|:   |:||||.|||:.:|.:||
Zfish   402 RIEDVTGLEMDTAEELQVANYGVGGQYEPHFDFGRKDEPDAFKELGTGNRIATWLFYMSDVSAGG 466

  Fly   415 ATIFPMINITVTPKKGSAVFWYNLHNSGAMNLKSLHSACPVISGSKYVLTKWINELPQMFVTPC 478
            ||:|..:...|.||||:|||||||..||..:..:.|:||||:.|:|:|..|||:|..|.|..||
Zfish   467 ATVFTDVGAAVWPKKGTAVFWYNLFPSGEGDYSTRHAACPVLVGNKWVSNKWIHERGQEFRRPC 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	36/130 (28%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	24/109 (22%)
		P4Hc	313..467	CDD:214780	60/168 (36%)
p4ha1b	NP_999856.1	P4Ha_N	24..153	CDD:285528	36/130 (28%)
		TPR repeat	164..199	CDD:276809	7/34 (21%)
		TPR_16	168..238	CDD:290168	13/69 (19%)
		TPR repeat	204..234	CDD:276809	5/29 (17%)
		P4Hc	347..520	CDD:214780	62/172 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920