Protein Alignment ORC4 and ORC4

DIOPT Version :10

• Sequence 1: NP_002543.2
• Gene: ORC4 / 5000
• HGNCID: 8490
• Length: 436
• Species: Homo sapiens
• Sequence 2: NP_015488.1
• Gene: ORC4 / 856291
• SGDID: S000006366
• Length: 529
• Species: Saccharomyces cerevisiae
• Alignment Length: 443
• Identity: 117/443 - (26%)
• Similarity: 201/443 - (45%)
• Gaps: 77/443 - (17%)

Human    45 KHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKI 109
            :.:..::|::.:..||:||:::|||.|.||.|:::.|..|.  :...|..:.:.|||.:. :::.
Yeast    80 QEIDRIIKQSIIQKESHSVILVGPRQSYKTYLLDYELSLLQ--QSYKEQFITIRLNGFIH-SEQT 141

Human   110 ALKEITRQL--NLENVVG--DKVFGSFAENLS------------FLLEALKKG--------DRTS 150
            |:..|..||  .|:.:.|  :|:..:..|.:|            .||::..|.        ||.|
Yeast   142 AINGIATQLEQQLQKIHGSEEKIDDTSLETISSGSLTEVFEKILLLLDSTTKTRNEDSGEVDRES 206

Human   151 --SCPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHR 213
              ...|:||.||.|.||....|||||||||:.:.::.|:.:.|.|.:|:|||.||||||||||.|
Yeast   207 ITKITVVFIFDEIDTFAGPVRQTLLYNLFDMVEHSRVPVCIFGCTTKLNILEYLEKRVKSRFSQR 271

Human   214 QIHLMNSFGFPQYVKIFKEQLSLPAEFPDKVFAEKWNENVQ-YLSEDRSVQEVLQKHFNIS-KNL 276
            .|::.........|...:..|::.:|.  ..:..:|||.:: .||:.||   .|.:|..:: :..
Yeast   272 VIYMPQIQNLDDMVDAVRNLLTVRSEI--SPWVSQWNETLEKELSDPRS---NLNRHIRMNFETF 331

Human   277 RSLHMLLMLALNRVTASHPF---MTAV------DLMEASQLCSMDSKANIVHGLSVLEICLIIAM 332
            |||..|....:..|..|..|   .||:      |:...:||  .::....:..||.||:.::|:.
Yeast   332 RSLPTLKNSIIPLVATSKNFGSLCTAIKSCSFLDIYNKNQL--SNNLTGRLQSLSDLELAILISA 394

Human   333 KHLNDIYEEEPFNFQMVYNEFQKFVQR---------------KAHSVYNFEKPV-------VMKA 375
            ..:....::..|||.:.|.|::|.::.               ...|.::.:..:       |...
Yeast   395 ARVALRAKDGSFNFNLAYAEYEKMIKAINSRIPTVAPTTNVGTGQSTFSIDNTIKLWLKKDVKNV 459

Human   376 FEHLQQLELIKPMERTSGNSQREYQLMKLLLDNTQIMNALQKYPNCPTDVRQW 428
            :|:|.||:.   ....|....|:.........|.|....:     .|.|:|.:
Yeast   460 WENLVQLDF---FTEKSAVGLRDNATAAFYASNYQFQGTM-----IPFDLRSY 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ORC4	NP_002543.2	CDC6	43..>226	CDD:441083	69/206 (33%)
		ORC4_C	228..415	CDD:464223	44/219 (20%)
ORC4	NP_015488.1	CDC6	81..>276	CDD:441083	72/220 (33%)
		ORC4_C	286..517	CDD:464223	43/211 (20%)