Protein Alignment ACO2 and ACO1

DIOPT Version :10

• Sequence 1: NP_001089.1
• Gene: ACO2 / 50
• HGNCID: 118
• Length: 780
• Species: Homo sapiens
• Sequence 2: NP_013407.1
• Gene: ACO1 / 851013
• SGDID: S000004295
• Length: 778
• Species: Saccharomyces cerevisiae
• Alignment Length: 761
• Identity: 512/761 - (67%)
• Similarity: 609/761 - (80%)
• Gaps: 1/761 - (0%)

Human    17 VRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRLNRPLTLSEKIVYGHLDDPASQE 81
            ||.....|.|.:.:||..:..|.:.:|:|....:.::|||||||||.|.:|||:|||||||..|:
Yeast    13 VRGLATVSNLTRDSKVNQNLLEDHSFINYKQNVETLDIVRKRLNRPFTYAEKILYGHLDDPHGQD 77

Human    82 IERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAVPSTIHCDHLIEAQVGGEKDLRRAKDI 146
            |:||.|||:|||||||.||||||||:|||:|:||.:||.|.|:||||||:|||||||||:||.|:
Yeast    78 IQRGVSYLKLRPDRVACQDATAQMAILQFMSAGLPQVAKPVTVHCDHLIQAQVGGEKDLKRAIDL 142

Human   147 NQEVYNFLATAGAKYGVGFWKPGSGIIHQIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGA 211
            |:|||:|||:|.|||.:|||||||||||||:|||||:||.|:|||||||||.||||.:.||||||
Yeast   143 NKEVYDFLASATAKYNMGFWKPGSGIIHQIVLENYAFPGALIIGTDSHTPNAGGLGQLAIGVGGA 207

Human   212 DAVDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSIS 276
            ||||||||.|||||.||::||||||.::||:||||:|||:|||.|||||||.||||.|.|||:.|
Yeast   208 DAVDVMAGRPWELKAPKILGVKLTGKMNGWTSPKDIILKLAGITTVKGGTGKIVEYFGDGVDTFS 272

Human   277 CTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGREDIANLADEF-KDHLVPDPGCHYDQLIEI 340
            .|||.|||||||||||||||||:|..|.:||..|||..||:.|..: ||.|..|....||:::||
Yeast   273 ATGMGTICNMGAEIGATTSVFPFNKSMIEYLEATGRGKIADFAKLYHKDLLSADKDAEYDEVVEI 337

Human   341 NLSELKPHINGPFTPDLAHPVAEVGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALA 405
            :|:.|:|:||||||||||.||:::.:||....||||:||||||||||||||||.|||::.|.|.|
Yeast   338 DLNTLEPYINGPFTPDLATPVSKMKEVAVANNWPLDVRVGLIGSCTNSSYEDMSRSASIVKDAAA 402

Human   406 HGLKCKSQFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVT 470
            ||||.|:.||:|||||||||||||||..:..::.||||||||||||||||||:|||||:|||||:
Yeast   403 HGLKSKTIFTVTPGSEQIRATIERDGQLETFKEFGGIVLANACGPCIGQWDRRDIKKGDKNTIVS 467

Human   471 SYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKG 535
            |||||||.|||.||:|||||.|||:|||.||||.|:|||.||.|...||.:|.|:.|..|.||:.
Yeast   468 SYNRNFTSRNDGNPQTHAFVASPELVTAFAIAGDLRFNPLTDKLKDKDGNEFMLKPPHGDGLPQR 532

Human   536 EFDPGQDTYQHPPKDSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAA 600
            .:|.|::|||.||.|.|...|.|||||.|||||:||..|||||.:|:.||||..||.||||||.|
Yeast   533 GYDAGENTYQAPPADRSTVEVKVSPTSDRLQLLKPFKPWDGKDAKDMPILIKAVGKTTTDHISMA 597

Human   601 GPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENY 665
            |||||:||||:|||||.:|||||.||.|||.|:|..|.|:..||||||.|:..||:||||||||:
Yeast   598 GPWLKYRGHLENISNNYMIGAINAENKKANCVKNVYTGEYKGVPDTARDYRDQGIKWVVIGDENF 662

Human   666 GEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQGLK 730
            ||||||||||||||.|||.|||||||||||||||||||||||.|.:||||:||:|.|::.|.||.
Yeast   663 GEGSSREHAALEPRFLGGFAIITKSFARIHETNLKKQGLLPLNFKNPADYDKINPDDRIDILGLA 727

Human   731 DFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMK 776
            :..||||:...:...||.....:|.||||:.|||||:.|||||::|
Yeast   728 ELAPGKPVTMRVHPKNGKPWDAVLTHTFNDEQIEWFKYGSALNKIK 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACO2	NP_001089.1	aconitase_mito	45..775	CDD:273561	503/730 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	528..560		14/31 (45%)
ACO1	NP_013407.1	aconitase_mito	41..772	CDD:273561	503/730 (69%)