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Protein Alignment ACO2 and mAcon1

DIOPT Version :9

Sequence 1:	NP_001089.1	Gene:	ACO2 / 50	HGNCID:	118	Length:	780	Species:	Homo sapiens
Sequence 2:	NP_001097186.2	Gene:	mAcon1 / 44149	FlyBaseID:	FBgn0010100	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	781	Identity:	562/781 - (71%)
Similarity:	646/781 - (82%)	Gaps:	13/781 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     8 VTRLQK-----ALGVRQYHVASVLCQRA-KVAMSHFEPNEYIHYDLLEKNINIVRKRLNRPLTLS 66
            |.||.|     |..|||:|.:   |..| |||:|.|:.:.|:.|:.|.|.:.:||.|||||||||
  Fly    12 VCRLGKHVASEATVVRQFHAS---CYTASKVALSKFDSDVYLPYEKLNKRLEVVRGRLNRPLTLS 73

Human    67 EKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAVPSTIHCDHLIE 131
            ||::|.||||||:|:|.||.||||||||||||||||||||:||||||||.|||||||:|||||||
  Fly    74 EKVLYSHLDDPANQDIVRGTSYLRLRPDRVAMQDATAQMALLQFISSGLKKVAVPSTVHCDHLIE 138

Human   132 AQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILENYAYPGVLLIGTDSHTP 196
            ||:||.|||.||||:|:|||:|||:..||||:|||||||||||||||||||:||:|:||||||||
  Fly   139 AQIGGPKDLARAKDLNKEVYDFLASTCAKYGLGFWKPGSGIIHQIILENYAFPGLLMIGTDSHTP 203

Human   197 NGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGT 261
            |||||||:||||||||||||||.|||||||||||||.|||.:|||:||||||||||.||||||||
  Fly   204 NGGGLGGLCIGVGGADAVDVMADIPWELKCPKVIGVNLTGKISGWTSPKDVILKVADILTVKGGT 268

Human   262 GAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGREDIANLADEFKDHL 326
            |||:||||.|||||||||||||||||||||||||:||:|.||..||..|||..||:.|.:::..:
  Fly   269 GAIIEYHGKGVDSISCTGMATICNMGAEIGATTSLFPFNQRMADYLKSTGRAGIASEAQKYQAKI 333

Human   327 V-PDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGKVAEKEGWPLDIRVGLIGSCTNSSY 390
            : .|..|.||:||||||..|:||:||||||||.||::::|:.::|.|:|:|||||||||||||||
  Fly   334 LSADKNCEYDELIEINLDTLEPHVNGPFTPDLGHPISKLGENSKKNGYPMDIRVGLIGSCTNSSY 398

Human   391 EDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQW 455
            |||||.|::||.|::||||.|..|.:|||||||||||||||.:::....||.|||||||||||||
  Fly   399 EDMGRCASIAKDAMSHGLKSKIPFNVTPGSEQIRATIERDGISEVFDKFGGTVLANACGPCIGQW 463

Human   456 DRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGK 520
            ||||:|||:||||||||||||||||||||.||.||||||:||||:|||.|.|||.||.|||.|||
  Fly   464 DRKDVKKGDKNTIVTSYNRNFTGRNDANPATHCFVTSPELVTALSIAGRLDFNPLTDELTGADGK 528

Human   521 KFRLEAPDADELPKGEFDPGQDTYQHPPKDSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQIL 585
            ||:|:||..||||...||||||||..||.......|.|.|.|.|||||||||||:|:||.||.:|
  Fly   529 KFKLKAPFGDELPAKGFDPGQDTYTAPPPSGENVKVAVDPKSTRLQLLEPFDKWNGQDLTDLTVL 593

Human   586 IKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYY 650
            ||||||||||||||||||||:||||||||||:.|||.|.||.:.|:::|.....:|.|||.||.|
  Fly   594 IKVKGKCTTDHISAAGPWLKYRGHLDNISNNMFIGATNYENNEMNNIKNQRNGSWGGVPDVARDY 658

Human   651 KKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADY 715
            |.:||:||.:|||||||||||||||||||||||||||.||||||||||||||||||||||:||||
  Fly   659 KANGIKWVAVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGLLPLTFANPADY 723

Human   716 NKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQ-ETILLNHTFNETQIEWFRAGSALNRMKELQ 779
            :||.|..|:::..||...||||:...||  ||.: |.|.||||.|:.||.||:|||||||||||.
  Fly   724 DKIQPTSKISLLNLKSLAPGKPVDAEIK--NGDKVERIKLNHTLNDLQIGWFKAGSALNRMKELA 786

Human   780 Q 780
            |
  Fly   787 Q 787

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.