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Protein Alignment ACO2 and Irp-1B

DIOPT Version :9

Sequence 1:	NP_001089.1	Gene:	ACO2 / 50	HGNCID:	118	Length:	780	Species:	Homo sapiens
Sequence 2:	NP_524303.2	Gene:	Irp-1B / 41269	FlyBaseID:	FBgn0024957	Length:	899	Species:	Drosophila melanogaster

Alignment Length:	907	Identity:	250/907 - (27%)
Similarity:	369/907 - (40%)	Gaps:	234/907 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    47 LLEK------NINIVRKRLNRPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQM 105
            |||.      |.:|:.|.:...|..|..:..|      |.::|     :..:|.||.:||.|...
  Fly    43 LLESAVRNCDNFHILEKDVQSILGWSPALKQG------SNDVE-----VSFKPARVILQDFTGVP 96

Human   106 AMLQF---------ISSGLSKV--AVPSTIHCDHLIEAQVGGEKDLRRAKDI-----------NQ 148
            |::.|         :.....|:  ..|:.:..||.::.      |..||.|.           |:
  Fly    97 AVVDFAAMRDAVLDLGGDPEKINPICPADLVIDHSVQV------DFARAPDALAKNQSLEFERNK 155

Human   149 EVYNFLATAGAKYGVGFWK------PGSGIIHQIILENYA---------------YPGVLLIGTD 192
            |.:.||     |:|...:.      |||||:||:.||..|               ||. .::|||
  Fly   156 ERFTFL-----KWGAKAFNNMLIVPPGSGIVHQVNLEYLARVVFENDATDGSKILYPD-SVVGTD 214

Human   193 SHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTV 257
            |||....|||.:..||||.:|..||.|....:..|:|||.||.|.||...:..|::|.:...|..
  Fly   215 SHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYKLEGKLSPLVTSTDLVLTITKHLRQ 279

Human   258 KGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGR---------- 312
            .|..|..||::||||..:|....|||.||..|.|||...||.:.....|:.:|.|
  Fly   280 LGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLGYMKQTNRSEKKIDIIRQ 344

Human   313 -----EDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTPD---------------L 357
                 :.:.|.||..:|.       .:.|.|.::||.:...::||..|.               |
  Fly   345 YLKATQQLRNYADAAQDP-------KFTQSITLDLSTVVTSVSGPKRPHDRVSVSDMPEDFKSCL 402

Human   358 AHPVAEVGKVAEKEG--------WP---------LDIRVGLIGSCTNSSYEDMGRSAA-VAKQAL 404
            :.||...|.....|.        |.         ..:.:..|.||||:|...:...|. :||:|:
  Fly   403 SSPVGFKGFAIAPEAQSAFGEFQWDDGKTYKLHHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAV 467

Human   405 AHGLKCKS--QFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQ---WDRKDIKKGE 464
            ..||....  :.:::|||..:...::..|....|..||..::...|..|||.   .:...:...|
  Fly   468 EKGLSILPYIKTSLSPGSGVVTYYLKESGVIPYLEKLGFDIVGYGCMTCIGNSGPLEENVVNTIE 532

Human   465 KNTI----VTSYNRNFTGRNDANPETHA-FVTSPEIVTALAIAGTLKFNPETDYLTGTD--GKKF 522
            ||.:    |.|.||||.||  .:|.|.| ::.||.:|.|.||||.:..:.|.:.| |.|  ||..
  Fly   533 KNGLVCAGVLSGNRNFEGR--IHPNTRANYLASPLLVIAYAIAGRVDIDFEKEPL-GVDANGKNV 594

Human   523 RLEA--PDADELPKGE---FDPG--QDTYQHPPKDSSGQHVDVSPTSQRLQLLE----------- 569
            .|:.  |...|:.:.|   ..|.  |:.|.   |...|     |...|.||:.|
  Fly   595 FLQDIWPTRSEIQEVENKHVIPAMFQEVYS---KIELG-----SQDWQTLQVSEGKLFSWSADST 651

Human   570 -----PFDKWDGKDLEDLQILIKVKGKC--------TTDHISAAGPWLK---------------- 605
                 ||.:...:||..||.:  .|.:|        ||||||.||...:
  Fly   652 YIKRPPFFEGMTRDLPKLQSI--QKARCLLFLGDSVTTDHISPAGSIARTSPAARFLSERNITPR 714

Human   606 -FRGHLDNISNNLLIGAINIENGKANSVR--NAVTQEFGP----VP--------DTARYYKKHGI 655
             |..:.....|:.:     :..|...::|  |.:.::.||    :|        |.|..|::.|.
  Fly   715 DFNSYGSRRGNDAI-----MSRGTFANIRLVNKLVEKTGPRTVHIPSQEELDIFDAAERYREEGT 774

Human   656 RWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHP 720
            ..|::..::||.||||:.||..|..||.:|:|.:|:.|||.:||...|::||.|........::.
  Fly   775 PLVLVVGKDYGSGSSRDWAAKGPFLLGVKAVIAESYERIHRSNLVGMGIIPLQFLPGQSAETLNL 839

Human   721 VDK------LTIQGLKDFTPGKPLKCIIKHPNGTQ-ETILLNHTFNETQIEWFRAGSALNRM 775
            ..:      |...|||   ||:.::.   ..:||. ||||...|  |..|.:::.|..||.|
  Fly   840 TGREVYNIALPESGLK---PGQKIQV---EADGTVFETILRFDT--EVDITYYKNGGILNYM 893

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.