Protein Alignment ORC2 and Orc2

DIOPT Version :10

• Sequence 1: XP_011509554.1
• Gene: ORC2 / 4999
• HGNCID: 8488
• Length: 597
• Species: Homo sapiens
• Sequence 2: NP_731873.1
• Gene: Orc2 / 41703
• FlyBaseID: FBgn0015270
• Length: 618
• Species: Drosophila melanogaster
• Alignment Length: 597
• Identity: 219/597 - (36%)
• Similarity: 324/597 - (54%)
• Gaps: 75/597 - (12%)

Human    29 REGGAKLKKERAQLLVNPKKIIKKPEYDLE--EDDQEVLKDQNYVEIMGRDVQESLKNGSATGGG 91
            :|...|.::||  ::||..::..:...|.|  |:::.:.:.:|......:|:.  |........|
  Fly    68 KESNGKGQEER--IVVNYVEMSDERSSDAEDQEEEESIEESENAARPAAKDLH--LIQSEYNVAG 128

Human    92 NKVYSFQNRKHSEKMAKLDLTFWPFFLTPHQRCASTIYASELAKTPQKSVSFSLKNDPEITINVP 156
            ..::.|...|..:.||...|...|  .||              |||:         .|.:.:..|
  Fly   129 TSMFGFNTPKKRDAMALAALNATP--CTP--------------KTPK---------TPRLGVKTP 168

Human   157 QSSKGHSASDKVQPKNNDKSEFLSTAPRSLRKRL------IVPRSHSD----------SESEYSA 205
            .:.:..|..   |||          .|..:|.|:      ||..|..|          |:.|.|:
  Fly   169 DTKRKKSMD---QPK----------TPAHVRTRVKKQIAKIVADSDEDFSGDESDFRPSDEESSS 220

Human   206 SNSEDDEGVAQEHEEDTNAVIFSQKIQAQ-NRVVSAPVGKETPSKRMKRD-----KTSDLVEE-- 262
            |:|..|.|    :..|.:|.....|..:: .|.:..||..:|||....|.     |:::.|.|
  Fly   221 SSSSSDAG----NSSDNDAADDEPKTPSRARRAIVVPVLPKTPSAARLRQSARAKKSNEFVPESD 281

Human   263 -YFEAHSSSKVLTSDRTLQKLKRAKLDQQTLRNLLSKVSPSFSAE--LKQLNQQYEKLFHKWMLQ 324
             ||.:|:|||:||||.||.:||..:|....:.:|||::..|...|  :..:.::|...|.|||..
  Fly   282 GYFHSHASSKILTSDHTLDRLKNPRLAADRVFSLLSEIKTSAEHEGSINAIMEEYRSYFPKWMCI 346

Human   325 LHLGFNIVLYGLGSKRDLLERFRTTMLQDSIHVVINGFFPGISVKSVLNSITEEVLDHMGTFRSI 389
            |:.||||:|||||||..||:.|...:|.....:|:|||||.:::|.:|:|||.::||...:..:.
  Fly   347 LNEGFNILLYGLGSKHQLLQSFHREVLHKQTVLVVNGFFPSLTIKDMLDSITSDILDAGISPANP 411

Human   390 LDQLDWIVNKFKEDSSLELFLLIHNLDSQMLRGEKSQQIIGQLSSLHNIYLIASIDHLNAPLMWD 454
            .:.:|.|..:|.......|||::||||..|||..|:|.|:.:|:.:.||:|:|||||:|.||:||
  Fly   412 HEAVDMIEEEFALIPETHLFLIVHNLDGAMLRNVKAQAILSRLARIPNIHLLASIDHINTPLLWD 476

Human   455 HAKQSLFNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLTHVLRSLTPNARGIFRLLIKYQ 519
            ..|...||:.|::.||..|||.||::||||||:.||.|.|||:..|..|||.|:|||:.|::|||
  Fly   477 QGKLCSFNFSWWDCTTMLPYTNETAFENSLLVQNSGELALSSMRSVFSSLTTNSRGIYMLIVKYQ 541

Human   520 LDNQDNPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDNG 584
            |.|:.|.:|.|:.|:|.|..|||||||:|||.||||||||.||||:::|:..||.|.|.||:|..
  Fly   542 LKNKGNATYQGMPFRDLYSSCREAFLVSSDLALRAQLTEFLDHKLVKSKRSVDGSEQLTIPIDGA 606

Human   585 TLTDFLEKEEEE 596
            .|..|||::|::
  Fly   607 LLQQFLEEQEKK 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ORC2	XP_011509554.1	ORC2	276..585	CDD:461163	148/310 (48%)
Orc2	NP_731873.1	PTZ00449	<136..310	CDD:185628	58/215 (27%)
		ORC2	296..604	CDD:461163	147/307 (48%)