Protein Alignment Cadps and CADPS2

DIOPT Version :10

• Sequence 1: NP_001245439.1
• Gene: Cadps / 49968
• FlyBaseID: FBgn0053653
• Length: 1534
• Species: Drosophila melanogaster
• Sequence 2: NP_001350318.1
• Gene: CADPS2 / 93664
• HGNCID: 16018
• Length: 1308
• Species: Homo sapiens
• Alignment Length: 1507
• Identity: 790/1507 - (52%)
• Similarity: 1001/1507 - (66%)
• Gaps: 241/1507 - (15%)

  Fly     1 MIDPSSSEEEGEDDAVPNVSSKGRLTNTTKGTSAVSIIGGSAGSVVGSNIPVSGSNTDLIGNQRQ 65
            |:||||||||.::                                               |.:.:
Human     1 MLDPSSSEEESDE-----------------------------------------------GLEEE 18

  Fly    66 SNISSICNRNDVGNISVAALGSTSNKIEQICGNRADTGNLEVPSNGIPSGISQETLNQSVGSSRA 130
            |        .||    :.|.||                     |...|...::|....:.|.:..
Human    19 S--------RDV----LVAAGS---------------------SQRAPPAPTREGRRDAPGRAGG 50

  Fly   131 NSLPRPLSPSPSLTSEKHETAEPHGKHEREEEERKRRIQLYVFISRCISYPFNAKQPTDMTKRQT 195
            ....|.:|||||:.||..:  ||..:.: :|:||:.|:|||||:.|||:|||||||||||.:||.
Human    51 GGAARSVSPSPSVLSEGRD--EPQRQLD-DEQERRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQ 112

  Fly   196 KISKQQLEIITQRFQAFLKGETQIMADEAFQNAVQSYHDVFLKSERVLKMVQSGASSQHDFREVF 260
            |::||||:::.:||||||.|||||:|||||.|||:||::|||||:||.:|||||..|.:||||||
Human   113 KLNKQQLQLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSANDFREVF 177

  Fly   261 RNNIEKRVRSLPEIDGLSKETVLTSWMAKFDIILKGTGEED-SKRPSRMQQSLNSELILSKEQLY 324
            :.|||||||||||||||||||||:||:||:|.|.:  |||| .|:|:||..|..|||||||||||
Human   178 KKNIEKRVRSLPEIDGLSKETVLSSWIAKYDAIYR--GEEDLCKQPNRMALSAVSELILSKEQLY 240

  Fly   325 DMFQQILLVKKFEHQILFNALMLDSADEQAAAIRRELDGRMQRVGEMEKNRKLMPKFVLKEMESL 389
            :||||||.:||.|||:|:||..||:||||||.||||||||:|...:|.|.|| .|||:.|:||::
Human   241 EMFQQILGIKKLEHQLLYNACQLDNADEQAAQIRRELDGRLQLADKMAKERK-FPKFIAKDMENM 304

  Fly   390 YVEELKSSINLLMANLESLPVSKGNMDSKYGLQKLKRYNHSTPSFLKLILRSHGSLSKLEGDSED 454
            |:|||:||:|||||||||||||||..:.|  ||||||..:|  :||.:            ||  :
Human   305 YIEELRSSVNLLMANLESLPVSKGGPEFK--LQKLKRSQNS--AFLDI------------GD--E 351

  Fly   455 GSTQLTKLDVVLTFQLEVIVMEVKGLKSLAPNRIVYCTMEVENGEKLQTDQAEASKPMWDTQGDF 519
            ...||:|.||||:|.||:::|||:||||:||||||||||||| ||||||||||||:|.|.|||||
Human   352 NEIQLSKSDVVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEVE-GEKLQTDQAEASRPQWGTQGDF 415

  Fly   520 TTTHPLPVVKVKLYTENPGMLALEDKELGKVTLKPTPLSSKSPEWHRMIVPKNLPDQDIRIKIAC 584
            |||||.|||||||:||:.|:|||||||||:|.|.||..||||.|.|||:||||..|.|::||:|.
Human   416 TTTHPRPVVKVKLFTESTGVLALEDKELGRVILYPTSNSSKSAELHRMVVPKNSQDSDLKIKLAV 480

  Fly   585 RLDKPLNMKHCGYLYAIGKSVWKKWKRRYFVLVQVSQYTFAMCSYKEKKSEPSEMMQLDGYTVDY 649
            |:|||.:|||.|||||:|:.|||:||:||||||||||||||||||:||||||.|:|||:||||||
Human   481 RMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQELMQLEGYTVDY 545

  Fly   650 IEAASANLMFGIDLNGGRYFFNAVREGDSISFACDDENECSLWVMAMYRATGQSHKPTPPI-TQD 713
            .:....       |.||..|||||:|||::.||.|||.:..|||.|||||||||:||.|.| ||.
Human   546 TDPHPG-------LQGGCMFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQTQK 603

  Fly   714 KN------SAMSKIQG-DADKARKHGMEDFISTDPCTFDHATLFKTLQNLTLEYRLNDPYASLGW 771
            .|      .|.:::.| |||:.:||||::|||.:||..|||.||:.||..||::||||.|:.|||
Human   604 LNPKGGTLHADAQLSGKDADRFQKHGMDEFISANPCKLDHAFLFRILQRQTLDHRLNDSYSCLGW 668

  Fly   772 FSPGQVFVLDEYCARYGVRGCYRHLCYLSDLLDRAEKQHMIDPTLIHYSFAFCASHVHGNRPDGV 836
            |||||||||||||||||||||:||||||::|::.:|...:|||||:||||||||||||||||||:
Human   669 FSPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTLLHYSFAFCASHVHGNRPDGI 733

  Fly   837 GSITHEEKEKFSEIKERLRQLLEFQITNFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPPEE 901
            |:::.||||:|.||||||..|||.||::|||||||||||||||||||||||||||||.||:|.||
Human   734 GTVSVEEKERFEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEE 798

  Fly   902 VRQMIKKSLETAALVNYTRLSNKAKID-----EDLRGDVIVPAPKKLEDLIHLAELCVDLLQQNE 961
            |:::::|.||.|||:|||||:..|||:     |....:...|| :|||:::||||||:::|||||
Human   799 VKKVVRKCLEKAALINYTRLTEYAKIEGPAEKETETMNQASPA-RKLEEILHLAELCIEVLQQNE 862

  Fly   962 EHYGELRKHDKMDKKKLLKEDEDVSGGHNESEVDLIDSTGLISASELATAASTDGSSFRYCMPTH 1026
            ||:.|.|:
Human   863 EHHAEGRE--------------------------------------------------------- 870

  Fly  1027 AVYTPPVPTAFAWFSDLLVEHAEIFWSLFAVDMDRVLSEQAPDTWDSFPLFQILNDYLRTDDNLR 1091
                     ||||:.|||.||||.||:||.||||..|..|..|:||||||||:||::||.|..|.
Human   871 ---------AFAWWPDLLAEHAEKFWALFTVDMDTALEAQPQDSWDSFPLFQLLNNFLRNDTLLC 926

  Fly  1092 NGRFHQHLRDTFAPLVVRYVDLMESSIAQSIHKGFEKERWESKGINAALNPAALNNAAQALNTAA 1156
            ||:||:||::.|.|||||||||||||||||||:|||:|.|:           .:.|.|.:|...|
Human   927 NGKFHKHLQEIFVPLVVRYVDLMESSIAQSIHRGFEQETWQ-----------PVKNIANSLPNVA 980

  Fly  1157 LN--PSMILCGKKDQVNFYVPKLPKQSNST--AANDEMRNGCATSEDLFWKLDALQSFIRDLHWP 1217
            |.  ||:.|         .:|::|..|.::  .:..|..||.||||||||||||||.|:.|||||
Human   981 LPKVPSLPL---------NLPQIPNISTASWMPSLYESTNGSATSEDLFWKLDALQMFVFDLHWP 1036

  Fly  1218 DAEFRQHLEQRLKMMAVDMIEQCIQRTDSSFQSWLKKNIAFISTDYILPSEMCAMVNVILDAKNQ 1282
            :.||..|||||||:||.||:|.|::||.::|:..|:|  |..:||..:|:.:|.|.||::|||.|
Human  1037 EQEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQK--ASKTTDLRIPASVCTMFNVLVDAKKQ 1099

  Fly  1283 SFKLTTIDGIDLY-----KFHAKIDDQIDKANVAMTQGLSGKLMSVLESTLSKLARYDEGSLIGS 1342
            |.||..:||...:     ::|:||||.||.:...:...|..|.:||||..||||:|||||:...|
Human  1100 STKLCALDGGQEFGSQWQQYHSKIDDLIDNSVKEIISLLVSKFVSVLEGVLSKLSRYDEGTFFSS 1164

  Fly  1343 ILSFT--------NVSSSGKDLGQGYVNFFRNNMDQVRGKIADDLWTLHFFEQWYSQQINMLCNW 1399
            |||||        :|...|.||...|:.|.|.|.|.:|.|:.::::....|:||||..:.::|.|
Human  1165 ILSFTVKAAAKYVDVPKPGMDLADTYIMFVRQNQDILREKVNEEMYIEKLFDQWYSSSMKVICVW 1229

  Fly  1400 LSERVDHALHYAQVASISHIIKKIYSDFELQGVLEDKLNSKAYQAVAQRMATEEATCA------- 1457
            |::|:|..||..|:.::..|:||.|.||.||||||..||||.|..|.:|:..||||.:
Human  1230 LTDRLDLQLHIYQLKTLIKIVKKTYRDFRLQGVLEGTLNSKTYDTVHRRLTVEEATASVSEGGGL 1294

  Fly  1458 --LTMPDACEDE 1467
              :||.|:.|:|
Human  1295 QGITMKDSDEEE 1306

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cadps	NP_001245439.1	PH_CADPS	585..711	CDD:269940	84/126 (67%)
		MUN	904..1427	CDD:461870	229/544 (42%)
CADPS2	NP_001350318.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..78		30/159 (19%)
		C2	366..448	CDD:214577	66/82 (80%)
		PH_CADPS	481..600	CDD:269940	83/125 (66%)
		MUN	801..1257	CDD:461870	229/544 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1286..1308		5/21 (24%)