DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cadps and CADPS

DIOPT Version :9

Sequence 1:	NP_001245439.1	Gene:	Cadps / 49968	FlyBaseID:	FBgn0053653	Length:	1534	Species:	Drosophila melanogaster
Sequence 2:	XP_016862847.1	Gene:	CADPS / 8618	HGNCID:	1426	Length:	1433	Species:	Homo sapiens

Alignment Length:	1599	Identity:	821/1599 - (51%)
Similarity:	1032/1599 - (64%)	Gaps:	282/1599 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIDPSSSEEEGED--------DAVPNVSSKGRL--TNTTKGTSAVSIIGGSAGSVVGSNIPVSGS 55
            |:||||||||.::        :.:.:..|..||  :.|::|::..:.:|| .|:..|:.:...|.
Human     1 MLDPSSSEEESDEIVEEESGKEVLGSAPSGARLSPSRTSEGSAGSAGLGG-GGAGAGAGVGAGGG 64

  Fly    56 NTDLIGNQRQSNISSICNRNDVGNISVAALGSTSNKIEQICGNRADTGNLEVPSNGIPSGISQET 120
            .                                        |:.|.:|       |...|:..
Human    65 G----------------------------------------GSGASSG-------GGAGGLQP-- 80

  Fly   121 LNQSVGSSRANSLPRPLSPSPSLTSEKHETAEPHGKHEREEEERKRRIQLYVFISRCISYPFNAK 185
                  ||||.. .||.|||||:.|||.:  |...:.::||||||:|:|||||:.|||:||||||
Human    81 ------SSRAGG-GRPSSPSPSVVSEKEK--EELERLQKEEEERKKRLQLYVFVMRCIAYPFNAK 136

  Fly   186 QPTDMTKRQTKISKQQLEIITQRFQAFLKGETQIMADEAFQNAVQSYHDVFLKSERVLKMVQSGA 250
            |||||.:||.|||||||:.:..||||||.|||||||||||.||||||::|||||:||.:|||||.
Human   137 QPTDMARRQQKISKQQLQTVKDRFQAFLNGETQIMADEAFMNAVQSYYEVFLKSDRVARMVQSGG 201

  Fly   251 SSQHDFREVFRNNIEKRVRSLPEIDGLSKETVLTSWMAKFDIILKGTGEED-SKRPSRMQQSLNS 314
            .|.:|.||||:.:||||||||||||||||||||:|||||||.|.:  |||| .|:.:||..|..|
Human   202 CSANDSREVFKKHIEKRVRSLPEIDGLSKETVLSSWMAKFDAIYR--GEEDPRKQQARMTASAAS 264

  Fly   315 ELILSKEQLYDMFQQILLVKKFEHQILFNALMLDSADEQAAAIRRELDGRMQRVGEMEKNRKLMP 379
            ||||||||||:|||.||.:||||||:|:||..||:.|||||.||||||||:|...::.:.|| .|
Human   265 ELILSKEQLYEMFQNILGIKKFEHQLLYNACQLDNPDEQAAQIRRELDGRLQMADQIARERK-FP 328

  Fly   380 KFVLKEMESLYVEELKSSINLLMANLESLPVSKGNMDSKYGLQKLKRYNHSTPSFLKLILRSHGS 444
            |||.||||::|:||||||:|||||||||:|||||   .::.|||||              |||.
Human   329 KFVSKEMENMYIEELKSSVNLLMANLESMPVSKG---GEFKLQKLK--------------RSHN- 375

  Fly   445 LSKLEGDSEDGSTQLTKLDVVLTFQLEVIVMEVKGLKSLAPNRIVYCTMEVENGEKLQTDQAEAS 509
             :.:....|:...||:|.||||:|.|||::|||:||||||||||||||||||.||||||||||||
Human   376 -ASIIDMGEESENQLSKSDVVLSFSLEVVIMEVQGLKSLAPNRIVYCTMEVEGGEKLQTDQAEAS 439

  Fly   510 KPMWDTQGDFTTTHPLPVVKVKLYTENPGMLALEDKELGKVTLKPTPLSSKSPEWHRMIVPKNLP 574
            ||.|.|||||:|||.||.|||||:||:.|:|||||||||:|.|.|||.|.|..|||:|.|.||.|
Human   440 KPTWGTQGDFSTTHALPAVKVKLFTESTGVLALEDKELGRVILHPTPNSPKQSEWHKMTVSKNCP 504

  Fly   575 DQDIRIKIACRLDKPLNMKHCGYLYAIGKSVWKKWKRRYFVLVQVSQYTFAMCSYKEKKSEPSEM 639
            |||::||:|.|:|||.||||.|||:||||:|||:||:|:||||||||||||||||:|||:||.|:
Human   505 DQDLKIKLAVRMDKPQNMKHSGYLWAIGKNVWKRWKKRFFVLVQVSQYTFAMCSYREKKAEPQEL 569

  Fly   640 MQLDGYTVDYIEAASANLMFGIDLNGGRYFFNAVREGDSISFACDDENECSLWVMAMYRATGQSH 704
            :|||||||||.:....       |.|||.|||||:|||::.||.|||.:..|||.||||||||||
Human   570 LQLDGYTVDYTDPQPG-------LEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSH 627

  Fly   705 KPTPPITQDKNSA-----------MSKIQG--DADKARKHGMEDFISTDPCTFDHATLFKTLQNL 756
            ||.||....|.:|           :|:..|  |||:|:||||::|||::||.||||:||:.:|.|
Human   628 KPVPPTQVQKLNAKGGNVPQLDAPISQFSGLKDADRAQKHGMDEFISSNPCNFDHASLFEMVQRL 692

  Fly   757 TLEYRLNDPYASLGWFSPGQVFVLDEYCARYGVRGCYRHLCYLSDLLDRAEKQHMIDPTLIHYSF 821
            ||::||||.|:.||||||||||||||||||.|||||:||||||.|||:|||...||||||:||||
Human   693 TLDHRLNDSYSCLGWFSPGQVFVLDEYCARNGVRGCHRHLCYLRDLLERAENGAMIDPTLLHYSF 757

  Fly   822 AFCASHVHGN-----------------------------------------------------RP 833
            ||||||||||                                                     ||
Human   758 AFCASHVHGNSQQMHVYLSGLPPNTDPEGSKTPSPPEPEAKKDTKKESKKRKDSKTQANQELKRP 822

  Fly   834 DGVGSITHEEKEKFSEIKERLRQLLEFQITNFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVP 898
            ||:|::|.||||:|.|||||||.|||.|||:||||||||||||||||||||||||||||||||||
Human   823 DGIGTVTVEEKERFEEIKERLRVLLENQITHFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVP 887

  Fly   899 PEEVRQMIKKSLETAALVNYTRLSNKAKIDEDLR----------------------------GDV 935
            .|||:.:|:|.||.||||||:|||..|||:...|                            |.:
Human   888 QEEVKTVIRKCLEQAALVNYSRLSEYAKIEGKKREMYEHPVFCLASQVMDLTIQNQKDAENVGRL 952

  Fly   936 IVPAPKKLEDLIHLAELCVDLLQQNEEHYGELRKHDKMDKKKLLKEDEDVSGGHNESEVDLIDST 1000
            |.|| |||||.|.||||.:::|||||||                         |.|..||..:
Human   953 ITPA-KKLEDTIRLAELVIEVLQQNEEH-------------------------HAEPHVDKGE-- 989

  Fly  1001 GLISASELATAASTDGSSFRYCMPTHAVYTPPVPTAFAWFSDLLVEHAEIFWSLFAVDMDRVLSE 1065
                                               ||||:|||:|||||.|.||||||||..|..
Human   990 -----------------------------------AFAWWSDLMVEHAETFLSLFAVDMDAALEV 1019

  Fly  1066 QAPDTWDSFPLFQILNDYLRTDDNLRNGRFHQHLRDTFAPLVVRYVDLMESSIAQSIHKGFEKER 1130
            |.|||||||||||:|||:||||.||.||:||:||:|.|||||||||||||||||||||:|||:|.
Human  1020 QPPDTWDSFPLFQLLNDFLRTDYNLCNGKFHKHLQDLFAPLVVRYVDLMESSIAQSIHRGFERES 1084

  Fly  1131 WES-KGINAALNPAALNNAAQALNTAALNPSMILCGKKDQVNFYVPKLPKQSNST--AANDEMRN 1192
            ||. |.:.:.|....|.|    :|...: |::.:     .:...:|::|..|..:  ||..:..|
Human  1085 WEPVKSLTSNLPNVNLPN----VNLPKV-PNLPV-----NIPLGIPQMPTFSAPSWMAAIYDADN 1139

  Fly  1193 GCATSEDLFWKLDALQSFIRDLHWPDAEFRQHLEQRLKMMAVDMIEQCIQRTDSSFQSWLKKNIA 1257
            |..|||||||||||||:||||||||:.||.:|||||||:||.||||.|::||..:|:..|:|...
Human  1140 GSGTSEDLFWKLDALQTFIRDLHWPEEEFGKHLEQRLKLMASDMIESCVKRTRIAFEVKLQKTSR 1204

  Fly  1258 FISTDYILPSEMCAMVNVILDAKNQSFKLTTIDGIDLYKFHAKIDDQIDKANVAMTQGLSGKLMS 1322
              |||:.:|..:|.|.||::|||.||.||.:::....:::|:|||:.|::....|...|..|.::
Human  1205 --STDFRVPQSICTMFNVMVDAKAQSTKLCSMEMGQEHQYHSKIDELIEETVKEMITLLVAKFVT 1267

  Fly  1323 VLESTLSKLARYDEGSLIGSILSFT--------NVSSSGKDLGQGYVNFFRNNMDQVRGKIADDL 1379
            :||..|:||:|||||:|..|.||||        :|...|.|:...||.|.|::.|.:|.|:.:::
Human  1268 ILEGVLAKLSRYDEGTLFSSFLSFTVKAASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNEEM 1332

  Fly  1380 WTLHFFEQWYSQQINMLCNWLSERVDHALHYAQVASISHIIKKIYSDFELQGVLEDKLNSKAYQA 1444
            :....|:|||:..:|::|.||::|:|..||..|:.::..::||.|.||.|||||:..||||.|:.
Human  1333 YIERLFDQWYNSSMNVICTWLTDRMDLQLHIYQLKTLIRMVKKTYRDFRLQGVLDSTLNSKTYET 1397

  Fly  1445 VAQRMATEEATCALTMPDACEDEPCDEIREGEEEDNGDE 1483
            :..|:..||||.:::.....:.   ..:::.:|||..|:
Human  1398 IRNRLTVEEATASVSEGGGLQG---ISMKDSDEEDEEDD 1433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cadps	NP_001245439.1	PH_CADPS	585..711	CDD:269940	86/125 (69%)
		PH	593..699	CDD:278594	69/105 (66%)
		DUF1041	904..1066	CDD:283860	64/189 (34%)
CADPS	XP_016862847.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	535	1.000	Domainoid score	I273
eggNOG	1	0.900	-	-		E1_KOG3543
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2755
Inparanoid	1	1.050	1464	1.000	Inparanoid score	I110
Isobase	1	0.950	-	0	Normalized mean entropy	S2796
OMA	1	1.010	-	-		QHG48904
OrthoDB	1	1.010	-	-		D138870at2759
OrthoFinder	1	1.000	-	-		FOG0004367
OrthoInspector	1	1.000	-	-		otm40483
orthoMCL	1	0.900	-	-		OOG6_105391
Panther	1	1.100	-	-	LDO	PTHR12166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3090
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790