DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cadps and Unc13a

DIOPT Version :9

Sequence 1:	NP_001245439.1	Gene:	Cadps / 49968	FlyBaseID:	FBgn0053653	Length:	1534	Species:	Drosophila melanogaster
Sequence 2:	NP_074052.2	Gene:	Unc13a / 64829	RGDID:	619722	Length:	1735	Species:	Rattus norvegicus

Alignment Length:	1796	Identity:	311/1796 - (17%)
Similarity:	562/1796 - (31%)	Gaps:	672/1796 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 SSICNRNDVGNISVAALGSTSNKIEQICGNRADTGNLEVPSNGIPSGI----------------- 116
            |..||.|..|      .|..::..:....:| |:......||.||...
  Rat   172 SQCCNWNYFG------WGEQNDDPDSAVDDR-DSDYRSETSNSIPPPYYTTSQPNASVHQYSVRP 229

  Fly   117 ----SQETLNQSVGSSRANSLPRPLSPSPSL-----------TSEKHETAEP--HGKHERE-EEE 163
                |:|:.:.|:.|....|.||.|||:.|.           :|:..|..:|  |.....| ::|
  Rat   230 PPLGSRESYSDSMHSYEEFSEPRALSPTGSSRYASSGELSQGSSQLSEDFDPDEHSLQGSELDDE 294

  Fly   164 RKRRIQLYVFISRCISY-------------------------PFNAKQPTDMTKRQTKISKQQLE 203
            |.|  ..|......:||                         |...:...:..:.:.::.:::||
  Rat   295 RDR--DSYHSCHSSVSYHKDSPRWDQDEEDLEDLEDLEDEELPEEEELEEEELEEEEELEEEELE 357

  Fly   204 I-----ITQRFQAFLKGETQIMADE------AFQNAVQSYHD----VFLKSERVLKMVQSGASSQ 253
            :     :.....::.:.|...:|:.      :|..|.....|    |.:::..|.|.:...|:.:
  Rat   358 LEEEEEVPDDLASYTQQEDTTVAEPKEFKRISFPTAAPQKEDKVSAVPIEAPDVSKGIPKAATPE 422

  Fly   254 HD-----FREVFRNNIEKRVRSLPEIDGLSKETVLT----SWMAKFDII------LKGTGEEDSK 303
            ..     .:|......|:..||....:|...:..::    :|:..|:.:      .:|.||
  Rat   423 EKAAAECAQEAEPPKSEESFRSREAEEGQEGQDAMSRAKANWLRAFNKVRMQLQEARGEGE---- 483

  Fly   304 RPSRMQQSL------NSELILSKEQLYDMFQQILLVKKFEHQILFNALMLDSADEQAAAIRRELD 362
                |.:||      ...||:. :.:.|       ::|.:...|.:.|.:.....:.|.|...|
  Rat   484 ----MSKSLWFKGGPGGGLIII-DSMPD-------IRKRKPIPLVSDLAMSLVQSRKAGITSAL- 535

  Fly   363 GRMQRVGEMEKNRKLMPKFVLKEMESL---------------------YVEELKSSI-------- 398
                 ......|.:|......|.:::|                     |..|.:..:
  Rat   536 -----ASSTLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGM 595

  Fly   399 --------------NLLMANLESLPVSKGNMDSKYGLQ------------KLKRYNHSTPSFLKL 437
                          :||.|:.......|   .||:|.:            ::|....:.|...:|
  Rat   596 RCTECGVKCHEKCQDLLNADCLQRAAEK---SSKHGAEDRTQNIIMVLKDRMKIRERNKPEIFEL 657

  Fly   438 ILR-------SHGSLSKLEGDSE-DGSTQLTKLDVVLTFQLEVIVMEVKGL--KSLAPNRIVYCT 492
            |..       :|....|....|. ||:::.:.       ::.:.|:..:||  |....:...|.|
  Rat   658 IQEVFAVTKSAHTQQMKAVKQSVLDGTSKWSA-------KISITVVCAQGLQAKDKTGSSDPYVT 715

  Fly   493 MEVENGEKLQTDQAEASKPMWDTQGDFTTTHPLPVVKVKLYTENPGMLAL--------EDKELGK 549
            ::|...:|..........|:|:....|...:....:||:::.|:..:.:.        .|..||:
  Rat   716 VQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQ 780

  Fly   550 VTLKPTPLSSKSPEWHRMIVPKNLPDQDIRIKIACRLDKPLNMKHCGYLYAIGKSVWKKWKRRYF 614
            ..::...||.:...|:.:       |:        |.||.          |:..::      |..
  Rat   781 TIIEVRTLSGEMDVWYNL-------DK--------RTDKS----------AVSGAI------RLH 814

  Fly   615 VLVQVSQYTFAMCSYKEKKSEPSEMMQLDGYTVDYIEAASANLMFGIDLNGGRYFFNAVREGDSI 679
            :.|::.         .|:|..|        |.|.|
  Rat   815 ISVEIK---------GEEKVAP--------YHVQY------------------------------ 832

  Fly   680 SFACDDENECSLWVMAMYRATGQSHKPTPPITQDKNSAMSKI-QGDADKARKHGMEDFISTDPCT 743
              .|..||....                  :|..:|:.:.|| ....|.|.|           ..
  Rat   833 --TCLHENLFHF------------------VTDVQNNGVVKIPDAKGDDAWK-----------VY 866

  Fly   744 FDHATLFKTLQNLTLEYRLNDPYASLGWFSPGQVFVLDEYCARYGVRGCY-----------RHLC 797
            :|     :|.|.                       ::||:..||||...|           :::|
  Rat   867 YD-----ETAQE-----------------------IVDEFAMRYGVESIYQAMTHFACLSSKYMC 903

  Fly   798 -----YLSDLLD--RAEKQHMIDPTLIHYSFAFCASHVHGNRPDGVGSITHEEKEKFSEIKERLR 855
                 .:|.||.  .|...|....|.:..|..|.||:.              .||:|.::.::|.
  Rat   904 PGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNF--------------GKERFVKLLDQLH 954

  Fly   856 QLLEFQITNFRYCFPFGRPEGA--LKATLSLLE-----RVLMKDIVTPVPPEEVRQMIKKSLETA 913
            ..|...::.:|..||...||..  ||:|:.||.     |:.::::.:   |....|::|..::..
  Rat   955 NSLRIDLSMYRNNFPASSPERLQDLKSTVDLLTSITFFRMKVQELQS---PPRASQVVKDCVKAC 1016

  Fly   914 ALVNYTRLSNKA--------KIDEDLRGDVIV----PAPKKLEDLIHLAELCVDLLQQNEEHY-- 964
            ....|..:.|..        :.|...:|:|..    |:.|.|:....|..|.|.::::::..|
  Rat  1017 LNSTYEYIFNNCHELYGREYQTDPAKKGEVPPEEQGPSIKNLDFWSKLITLIVSIIEEDKNSYTP 1081

  Fly   965 -----------GELRKH--------------DKMDKKKLLKEDE------DVSGGHNESEVDLID 998
                       |::...              ::.||.:|.|..:      .|...:||...:|
  Rat  1082 CLNQFPQELNVGKISAEVMWSLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVKWLYNEYVAEL-- 1144

  Fly   999 STGLISASELATAASTDGSSFRYCMPTHAVYTPPVPTAFAWFSDLLV------------------ 1045
                                     ||.....|..|   |||...::
  Rat  1145 -------------------------PTFKDRVPEYP---AWFEPFVIQWLDENEEVSRDFLHGAL 1181

  Fly  1046 ------------EHAEIFWSLFAVDMDRVLSE--------QAPDTWDSFPLFQILNDYLRTDDNL 1090
                        |||  .:|...||:...|::        :.||.       ||:..|:|
  Rat  1182 ERDKKDGFQQTSEHA--LFSCSVVDVFSQLNQSFEIIKKLECPDP-------QIVGHYMR----- 1232

  Fly  1091 RNGRFHQHLRDTFAPLVVRYVDLMESSIAQSIHKGFEKERWESKGINAALNPAALNNAAQALNTA 1155
               ||.:    |.:.::::|.|::....|....|  |||:          .|..|.|..|.|...
  Rat  1233 ---RFAK----TISNVLLQYADIVSKDFASYCSK--EKEK----------VPCILMNNTQQLRVQ 1278

  Fly  1156 ALNPSMILCGKK--DQVNFYVPKLPKQSNSTAANDEMRNGCATSEDLFWKLDALQSFIRDLHWPD 1218
            .......:.||:  .:.:..:.:|..:.|:..  ||:.:..|||
  Rat  1279 LEKMFEAMGGKELDAEASGTLKELQVKLNNVL--DELSHVFATS--------------------- 1320

  Fly  1219 AEFRQHLEQRLKMMAVDMIEQCIQRTDSSFQSWLKKNIAFISTDYILPSEMCAMVNVILDAKNQS 1283
              |:.|:|:.::.|. |::.| ::.|.:                  :|:..|:  :|..||.|..
  Rat  1321 --FQPHIEECVRQMG-DILSQ-VKGTGN------------------VPASACS--SVAQDADNVL 1361

  Fly  1284 FKLTTIDGIDLYKFHAKIDDQIDKANVAMTQGLSGKLMSVLESTLSKLARYDEGSLIGSILSFTN 1348
            ..:..:...:|..| |||.::.....|  .:.|...:|:.:|.|: .|....:.::||::|
  Rat  1362 QPIMDLLDSNLTLF-AKICEKTVLKRV--LKELWKLVMNTMERTI-VLPPLTDQTMIGTLL---- 1418

  Fly  1349 VSSSGKDLGQGYVNFFRNNMDQVRGKIADDLWTLHFFEQWYSQQINMLCN------WLSERVDH- 1406
             ...||.|.:|            |.|:..           :|....|:.|      .||:..||
  Rat  1419 -RKHGKGLEKG------------RVKLPS-----------HSDGTQMIFNAAKELGQLSKLKDHM 1459

  Fly  1407 ------ALHYAQVASISHIIKKIYSDFELQGV------LEDK--LNSKAYQAVAQRMATEEATCA 1457
                  :|...|.|.:...:..|...|...||      ||..  |.|..|.......||:.....
  Rat  1460 VREEAKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPDLQSLRYALSLYTQATDLLIKT 1524

  Fly  1458 LTMPDACE------------DEPCDEIREGEEEDNGDEST-----SNIPRGLPK--PKVAAA--- 1500
            .....:.:            ::.|.|:..|.|:..|:.|.     ::...|..|  .||.||
  Rat  1525 FVQTQSAQVHGGKGTRFTLSEDVCPEMGSGVEDPVGEVSVHVELFTHPGTGEQKVTVKVVAANDL 1589

  Fly  1501 --QAAAV------TNVVAGRVGNLLGKGIGGLSSKLGSGSW 1533
              |.:.:      .|:|..::.:...|    .::|..:.||
  Rat  1590 KWQTSGIFRPFIEVNIVGPQLSDKKRK----FATKSKNNSW 1626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cadps	NP_001245439.1	PH_CADPS	585..711	CDD:269940	15/125 (12%)
		PH	593..699	CDD:278594	12/105 (11%)
		DUF1041	904..1066	CDD:283860	37/244 (15%)
Unc13a	NP_074052.2	C2A_Munc13	1..127	CDD:176040
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	185..458		45/275 (16%)
		C1	567..616	CDD:197519	5/48 (10%)
		C2B_Munc13	689..815	CDD:175993	26/163 (16%)
		C2C_Munc13	1578..1697	CDD:176041	12/53 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000