DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cadps and Unc13a

DIOPT Version :9

Sequence 1:	NP_001245439.1	Gene:	Cadps / 49968	FlyBaseID:	FBgn0053653	Length:	1534	Species:	Drosophila melanogaster
Sequence 2:	XP_017168363.1	Gene:	Unc13a / 382018	MGIID:	3051532	Length:	1736	Species:	Mus musculus

Alignment Length:	1650	Identity:	286/1650 - (17%)
Similarity:	502/1650 - (30%)	Gaps:	681/1650 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 ANSLPRPLSPSPSLTSEKHETAEPHGKHE----REEEE-------------------RKRRIQLY 171
            |..:|:..:|.....:|:.:.|||....|    |||||                   .|.|:||.
Mouse   413 AKGIPKAATPEEKAAAERAQEAEPPKSEESFRSREEEEGQEGQDAMSRAKANWLRAFNKVRMQLQ 477

  Fly   172 VFISRCISYPFNAKQPTDMTK---------------------RQTK----ISKQQLEIITQRFQA 211
                       .|:...||:|                     |:.|    :|...:.::..|
Mouse   478 -----------EARGEGDMSKSLWFKGGPGGGLIIIDSMPDIRKRKPIPLVSDLAMSLVQSR--- 528

  Fly   212 FLKGETQIMADEAFQNAVQSYHDVFLKSERVLKMVQSGASSQHDFREVFRNNIEKRVRSLP---- 272
             ..|.|..:|.....|.....| |:.|:.:.| :.....::.|:| ||:       ..:.|
Mouse   529 -KAGITSALASSTLNNEELKNH-VYKKTLQAL-IYPISCTTPHNF-EVW-------TATTPTYCY 582

  Fly   273 EIDGL----------SKETVLTSWMAKFDII----LKGTGEEDSKRPSRMQQSLNSELIL----- 318
            |.:||          ..|..:.......|::    |:...|:.||..:. .::.|..::|
Mouse   583 ECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSKHGAE-DRTQNIIMVLKDRMK 646

  Fly   319 ----SKEQLYDMFQQILLVKKFEHQILFNALMLDSADEQAAAIRRE-LDGRMQRVGEMEKNRKLM 378
                :|.:::::.|:|..|.|..|            .:|..|:::. |||..:
Mouse   647 IRERNKPEIFELIQEIFAVTKSAH------------TQQMKAVKQSVLDGTSK------------ 687

  Fly   379 PKFVLKEMESLYVEELKSSINLLMANLESLPVSKGNMDSKYGLQKLKRYNHSTPSFLKLILRSHG 443
                         ...|.||.::.|.               |||...:...|.|
Mouse   688 -------------WSAKISITVVCAQ---------------GLQAKDKTGSSDP----------- 713

  Fly   444 SLSKLEGDSEDGSTQLTKLDVVLTFQLEVIVMEVKGLKSLAPNRIVYCTMEVENGEKLQTDQAEA 508
                                                          |.|::|...:|........
Mouse   714 ----------------------------------------------YVTVQVGKTKKRTKTIYGN 732

  Fly   509 SKPMWDTQGDFTTTHPLPVVKVKLYTENPGMLAL--------EDKELGKVTLKPTPLSSKSPEWH 565
            ..|:|:....|...:....:||:::.|:..:.:.        .|..||:..::...||.:...|:
Mouse   733 LNPVWEENFHFECHNSSDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWY 797

  Fly   566 RMIVPKNLPDQDIRIKIACRLDKPLNMKHCGYLYAIGKSVWKKWKRRYFVLVQVSQYTFAMCSYK 630
            .:       |:        |.||.          |:..::      |..:.|::.         .
Mouse   798 NL-------DK--------RTDKS----------AVSGAI------RLHISVEIK---------G 822

  Fly   631 EKKSEPSEMMQLDGYTVDYIEAASANLMFGIDLNGGRYFFNAVREGDSISFACDDENECSLWVMA 695
            |:|..|        |.|.|                                .|..||....
Mouse   823 EEKVAP--------YHVQY--------------------------------TCLHENLFHF---- 843

  Fly   696 MYRATGQSHKPTPPITQDKNSAMSKI-QGDADKARKHGMEDFISTDPCTFDHATLFKTLQNLTLE 759
                          :|..:|:.:.|| ....|.|.|           ..:|     :|.|.
Mouse   844 --------------VTDVQNNGVVKIPDAKGDDAWK-----------VYYD-----ETAQE---- 874

  Fly   760 YRLNDPYASLGWFSPGQVFVLDEYCARYGVRGCY-----------RHLC-----YLSDLLD--RA 806
                               ::||:..||||...|           :::|     .:|.||.  .|
Mouse   875 -------------------IVDEFAMRYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINA 920

  Fly   807 EKQHMIDPTLIHYSFAFCASHVHGNRPDGVGSITHEEKEKFSEIKERLRQLLEFQITNFRYCFPF 871
            ...|....|.:..|..|.||:.              .||:|.::.::|...|...::.:|..||.
Mouse   921 YYAHTTASTNVSASDRFAASNF--------------GKERFVKLLDQLHNSLRIDLSMYRNNFPA 971

  Fly   872 GRPEGA--LKATLSLLE-----RVLMKDIVTPVPPEEVRQMIKKSLETAALVNYTRLSNKA---- 925
            ..||..  ||:|:.||.     |:.::::.:   |....|::|..::......|..:.|..
Mouse   972 SSPERLQDLKSTVDLLTSITFFRMKVQELQS---PPRASQVVKDCVKACLNSTYEYIFNNCHELY 1033

  Fly   926 ----KIDEDLRGDVIV----PAPKKLEDLIHLAELCVDLLQQNEEHY-------------GELRK 969
                :.|...:|:|..    |:.|.|:....|..|.|.::::::..|             |::..
Mouse  1034 GREYQTDPAKKGEVPPEEQGPSIKNLDFWSKLITLIVSIIEEDKNSYTPCLNQFPQELNVGKISA 1098

  Fly   970 H--------------DKMDKKKLLKEDE------DVSGGHNESEVDLIDSTGLISASELATAAST 1014
            .              ::.||.:|.|..:      .|...:||...:|
Mouse  1099 EVMWSLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVKWLYNEYVAEL------------------ 1145

  Fly  1015 DGSSFRYCMPTHAVYTPPVPTAFAWFSDLLV------------------------------EHAE 1049
                     ||.....|..|   |||...::                              |||
Mouse  1146 ---------PTFKDRVPEYP---AWFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSEHA- 1197

  Fly  1050 IFWSLFAVDMDRVLSE--------QAPDTWDSFPLFQILNDYLRTDDNLRNGRFHQHLRDTFAPL 1106
             .:|...||:...|::        :.||.       ||:..|:|        ||.:    |.:.:
Mouse  1198 -LFSCSVVDVFSQLNQSFEIIKKLECPDP-------QIVGHYMR--------RFAK----TISNV 1242

  Fly  1107 VVRYVDLMESSIAQSIHKGFEKERWESKGINAALNPAALNNAAQALNTAALNPSMILCGKK--DQ 1169
            :::|.|::....|....|  |||:          .|..|.|..|.|..........:.||:  .:
Mouse  1243 LLQYADIVSKDFASYCSK--EKEK----------VPCILMNNTQQLRVQLEKMFEAMGGKELDAE 1295

  Fly  1170 VNFYVPKLPKQSNSTAANDEMRNGCATSEDLFWKLDALQSFIRDLHWPDAEFRQHLEQRLKMMAV 1234
            .:..:.:|..:.|:..  ||:.:..|||                       |:.|:|:.::.|.
Mouse  1296 ASGTLKELQVKLNNVL--DELSHVFATS-----------------------FQPHIEECVRQMG- 1334

  Fly  1235 DMIEQCIQRTDSSFQSWLKKNIAFISTDYILPSEMCAMVNVILDAKNQSFKLTTIDGIDLYKFHA 1299
            |::.| ::.|.:                  :|:..|:  :|..||.|....:..:...:|..| |
Mouse  1335 DILSQ-VKGTGN------------------VPASACS--SVAQDADNVLQPIMDLLDSNLTLF-A 1377

  Fly  1300 KIDDQIDKANVAMTQGLSGKLMSVLESTLSKLARYDEGSLIGSILSFTNVSSSGKDLGQGYVNFF 1364
            ||.::.....|  .:.|...:|:.:|.|: .|....:.::||::|     ...||.|.:|
Mouse  1378 KICEKTVLKRV--LKELWKLVMNTMEKTI-VLPPLTDQTMIGTLL-----RKHGKGLEKG----- 1429

  Fly  1365 RNNMDQVRGKIADDLWTLHFFEQWYSQQINMLCN------WLSERVDH-------ALHYAQVASI 1416
                   |.|:..           :|....|:.|      .||:..||       :|...|.|.:
Mouse  1430 -------RVKLPS-----------HSDGTQMIFNAAKELGQLSKLKDHMVREEAKSLTPKQCAVV 1476

  Fly  1417 SHIIKKIYSDFELQGV------LEDK--LNSKAYQAVAQRMATEEATCALTMPDACE-------- 1465
            ...:..|...|...||      ||..  |.|..|.......||:..........:.:
Mouse  1477 ELALDTIKQYFHAGGVGLKKTFLEKSPDLQSLRYALSLYTQATDLLIKTFVQTQSAQVHGGKGTR 1541

  Fly  1466 ----DEPCDEIREGEEEDNGDEST-----SNIPRGLPK--PKVAAA-----QAAAV------TNV 1508
                ::.|.|:..|.|:..|:.|.     ::...|..|  .||.||     |.:.:      .|:
Mouse  1542 FTLSEDVCPEMGSGVEDPVGEVSVHVELFTHPGTGEQKVTVKVVAANDLKWQTSGIFRPFIEVNI 1606

  Fly  1509 VAGRVGNLLGKGIGGLSSKLGSGSW 1533
            |..::.:...|    .::|..:.||
Mouse  1607 VGPQLSDKKRK----FATKSKNNSW 1627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cadps	NP_001245439.1	PH_CADPS	585..711	CDD:269940	15/125 (12%)
		PH	593..699	CDD:278594	12/105 (11%)
		DUF1041	904..1066	CDD:283860	37/244 (15%)
Unc13a	XP_017168363.1	C2A_Munc13	1..127	CDD:176040
		C1	568..617	CDD:237996	10/56 (18%)
		C2B_Munc13	690..816	CDD:175993	31/228 (14%)
		DUF1041	1008..1114	CDD:368829	15/105 (14%)
		Membr_traf_MHD	1360..1522	CDD:371123	42/193 (22%)
		C2C_Munc13	1579..1698	CDD:176041	11/52 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000