DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cadps and Cadps

DIOPT Version :9

Sequence 1:	NP_001245439.1	Gene:	Cadps / 49968	FlyBaseID:	FBgn0053653	Length:	1534	Species:	Drosophila melanogaster
Sequence 2:	XP_038948969.1	Gene:	Cadps / 26989	RGDID:	708573	Length:	1381	Species:	Rattus norvegicus

Alignment Length:	1547	Identity:	820/1547 - (53%)
Similarity:	1034/1547 - (66%)	Gaps:	230/1547 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIDPSSSEEEGED--------DAVPNVSSKGRL--TNTTKGTSAVSIIGGS-AGSVVGSNIPVSG 54
            |:||||||||.::        :.:.:.:|..||  :.|::|::..:.:||| ||:.||:
  Rat     1 MLDPSSSEEESDEILEEESGKEVLGSAASGARLSPSRTSEGSAGSAGMGGSGAGAGVGA------ 59

  Fly    55 SNTDLIGNQRQSNISSICNRNDVGNISVAALGSTSNKIEQICGNRADTGNLEVPSNGIPSGISQE 119
                                                      |....:|   ..|.|...|:..
  Rat    60 ------------------------------------------GGGGGSG---ASSGGGAGGLQP- 78

  Fly   120 TLNQSVGSSRANSLPRPLSPSPSLTSEKHETAEPHGKHEREEEERKRRIQLYVFISRCISYPFNA 184
                   ||||.. .||.|||||:.|||.:  |...:.::||||||:|:|||||:.|||:|||||
  Rat    79 -------SSRAGG-GRPSSPSPSVVSEKEK--EELERLQKEEEERKKRLQLYVFVMRCIAYPFNA 133

  Fly   185 KQPTDMTKRQTKISKQQLEIITQRFQAFLKGETQIMADEAFQNAVQSYHDVFLKSERVLKMVQSG 249
            ||||||.:||.|||||||:.:..||||||.|||||:|||||.||||||::|||||:||.:|||||
  Rat   134 KQPTDMARRQQKISKQQLQTVKDRFQAFLNGETQIVADEAFMNAVQSYYEVFLKSDRVARMVQSG 198

  Fly   250 ASSQHDFREVFRNNIEKRVRSLPEIDGLSKETVLTSWMAKFDIILKGTGEED-SKRPSRMQQSLN 313
            ..|.:|.||||:.:||||||||||||||||||||:|||||||.|.:  |||| .|:.:||..|..
  Rat   199 GCSANDSREVFKKHIEKRVRSLPEIDGLSKETVLSSWMAKFDAIYR--GEEDPRKQQARMTASAA 261

  Fly   314 SELILSKEQLYDMFQQILLVKKFEHQILFNALMLDSADEQAAAIRRELDGRMQRVGEMEKNRKLM 378
            |||||||||||:|||.||.:||||||:|:||..||:.|||||.||||||||:|...::.:.|| .
  Rat   262 SELILSKEQLYEMFQNILGIKKFEHQLLYNACQLDNPDEQAAQIRRELDGRLQMADQIARERK-F 325

  Fly   379 PKFVLKEMESLYVEELKSSINLLMANLESLPVSKGNMDSKYGLQKLKRYNHSTPSFLKLILRSHG 443
            ||||.||||::|:||||||:|||||||||:|||||   .::.|||||              |||.
  Rat   326 PKFVSKEMENMYIEELKSSVNLLMANLESMPVSKG---GEFKLQKLK--------------RSHN 373

  Fly   444 SLSKLEGDSEDGSTQLTKLDVVLTFQLEVIVMEVKGLKSLAPNRIVYCTMEVENGEKLQTDQAEA 508
              :.:....|:...||:|.||:|:|.|||::|||:||||||||||||||||||.|||||||||||
  Rat   374 --ASIIDMGEESENQLSKSDVLLSFSLEVVIMEVQGLKSLAPNRIVYCTMEVEGGEKLQTDQAEA 436

  Fly   509 SKPMWDTQGDFTTTHPLPVVKVKLYTENPGMLALEDKELGKVTLKPTPLSSKSPEWHRMIVPKNL 573
            |||.|.|||||:|||.||.|||||:||:.|:|||||||||:|.|.|||.|.|..|||:|.|.||.
  Rat   437 SKPTWGTQGDFSTTHALPAVKVKLFTESTGVLALEDKELGRVILHPTPNSPKQSEWHKMTVSKNC 501

  Fly   574 PDQDIRIKIACRLDKPLNMKHCGYLYAIGKSVWKKWKRRYFVLVQVSQYTFAMCSYKEKKSEPSE 638
            ||||::||:|.|:|||.||||.|||:.|||:|||:||:|:||||||||||||||||:|||:||.|
  Rat   502 PDQDLKIKLAVRMDKPQNMKHSGYLWTIGKNVWKRWKKRFFVLVQVSQYTFAMCSYREKKAEPQE 566

  Fly   639 MMQLDGYTVDYIEAASANLMFGIDLNGGRYFFNAVREGDSISFACDDENECSLWVMAMYRATGQS 703
            ::|||||||||.:....       |.|||.|||||:|||::.||.|||.:..|||.|||||||||
  Rat   567 LLQLDGYTVDYTDPQPG-------LEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQS 624

  Fly   704 HKPTPPITQDKNSA-----------MSKIQG--DADKARKHGMEDFISTDPCTFDHATLFKTLQN 755
            |||.||....|.:|           :|:..|  |||:|:||||::|||::||.||||:||:.:|.
  Rat   625 HKPVPPTQVQKLNAKGGNVPQLDAPISQFSGPKDADRAQKHGMDEFISSNPCNFDHASLFEMVQR 689

  Fly   756 LTLEYRLNDPYASLGWFSPGQVFVLDEYCARYGVRGCYRHLCYLSDLLDRAEKQHMIDPTLIHYS 820
            |||::||||.|:.||||||||||||||||||.|||||:||||||.|||:|||...||||||:|||
  Rat   690 LTLDHRLNDSYSCLGWFSPGQVFVLDEYCARNGVRGCHRHLCYLRDLLERAENGAMIDPTLLHYS 754

  Fly   821 FAFCASHVHGNRPDGVGSITHEEKEKFSEIKERLRQLLEFQITNFRYCFPFGRPEGALKATLSLL 885
            |||||||||||||||:|::|.||||:|.|||||||.|||.|||:|||||||||||||||||||||
  Rat   755 FAFCASHVHGNRPDGIGTVTVEEKERFEEIKERLRVLLENQITHFRYCFPFGRPEGALKATLSLL 819

  Fly   886 ERVLMKDIVTPVPPEEVRQMIKKSLETAALVNYTRLSNKAKIDEDLR------------------ 932
            |||||||||||||.|||:.:|:|.||.||||||:|||..|||:...|
  Rat   820 ERVLMKDIVTPVPQEEVKTVIRKCLEQAALVNYSRLSEYAKIEGKKREMYEHPVFCLASQVMDLT 884

  Fly   933 ----------GDVIVPAPKKLEDLIHLAELCVDLLQQNEEHYGELRKHDKMDKKKLLKEDEDVSG 987
                      |.:|.|| |||||.|.||||.:::|||||||:.| .|...:||.:
  Rat   885 IQNQKDAENVGRLITPA-KKLEDTIRLAELVIEVLQQNEEHHAE-GKEPHVDKGE---------- 937

  Fly   988 GHNESEVDLIDSTGLISASELATAASTDGSSFRYCMPTHAVYTPPVPTAFAWFSDLLVEHAEIFW 1052
                                                            ||||:|||:|||||.|.
  Rat   938 ------------------------------------------------AFAWWSDLMVEHAETFL 954

  Fly  1053 SLFAVDMDRVLSEQAPDTWDSFPLFQILNDYLRTDDNLRNGRFHQHLRDTFAPLVVRYVDLMESS 1117
            ||||||||..|..|.|||||||||||:|||:||||.||.||:||:||:|.|||||||||||||||
  Rat   955 SLFAVDMDAALEVQPPDTWDSFPLFQLLNDFLRTDYNLCNGKFHKHLQDLFAPLVVRYVDLMESS 1019

  Fly  1118 IAQSIHKGFEKERWES-KGINAALNPAALNNAAQALNTAALNPSMILCGKKDQVNFYVPKLPKQS 1181
            ||||||:|||:|.||. |.:.:.|....|.|    :|...: |::.:     .:...:|::|..|
  Rat  1020 IAQSIHRGFERESWEPVKSLTSNLPNVNLPN----VNLPKV-PNLPV-----NIPLGIPQMPTFS 1074

  Fly  1182 NST--AANDEMRNGCATSEDLFWKLDALQSFIRDLHWPDAEFRQHLEQRLKMMAVDMIEQCIQRT 1244
            ..:  ||..:..||..|||||||||||||:||||||||:.||.:|||||||:||.||||.|::||
  Rat  1075 APSWMAAIYDADNGSGTSEDLFWKLDALQTFIRDLHWPEEEFGKHLEQRLKLMASDMIESCVKRT 1139

  Fly  1245 DSSFQSWLKKNIAFISTDYILPSEMCAMVNVILDAKNQSFKLTTIDGIDLYKFHAKIDDQIDKAN 1309
            ..:|:..|:|...  |||:.:|..:|.|.||::|||.||.||.:::....:::|:|||:.|::..
  Rat  1140 RIAFEVKLQKTSR--STDFRVPQSICTMFNVMVDAKAQSTKLCSMEMGQEHQYHSKIDELIEETV 1202

  Fly  1310 VAMTQGLSGKLMSVLESTLSKLARYDEGSLIGSILSFT--------NVSSSGKDLGQGYVNFFRN 1366
            ..|...|..|.:::||..|:||:|||||:|..|.||||        :|...|.|:...||.|.|:
  Rat  1203 KEMITLLVAKFVTILEGVLAKLSRYDEGTLFSSFLSFTVKAASKYVDVPKPGMDVADAYVTFVRH 1267

  Fly  1367 NMDQVRGKIADDLWTLHFFEQWYSQQINMLCNWLSERVDHALHYAQVASISHIIKKIYSDFELQG 1431
            :.|.:|.|:.::::....|:|||:..:|::|.||::|:|..||..|:.::..::||.|.||.|||
  Rat  1268 SQDVLRDKVNEEMYIERLFDQWYNSSMNVICTWLTDRMDLQLHIYQLKTLIRMVKKTYRDFRLQG 1332

  Fly  1432 VLEDKLNSKAYQAVAQRMATEEATCALTMPDACEDEPCDEIREGEEEDNGDE 1483
            ||:..||||.|:.:..|:..||||.:::.....:.   ..:::.:|||..|:
  Rat  1333 VLDSTLNSKTYETIRNRLTVEEATASVSEGGGLQG---ISMKDSDEEDEEDD 1381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cadps	NP_001245439.1	PH_CADPS	585..711	CDD:269940	85/125 (68%)
		PH	593..699	CDD:278594	68/105 (65%)
		DUF1041	904..1066	CDD:283860	64/189 (34%)
Cadps	XP_038948969.1	PH_CADPS	513..632	CDD:269940	85/118 (72%)
Cadps	XP_038948969.1	DUF1041	838..968	CDD:399355	95/157 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341049
Domainoid	1	1.000	530	1.000	Domainoid score	I277
eggNOG	1	0.900	-	-		E1_KOG3543
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2755
Inparanoid	1	1.050	1422	1.000	Inparanoid score	I108
OMA	1	1.010	-	-		QHG48904
OrthoDB	1	1.010	-	-		D138870at2759
OrthoFinder	1	1.000	-	-		FOG0004367
OrthoInspector	1	1.000	-	-		otm44625
orthoMCL	1	0.900	-	-		OOG6_105391
Panther	1	1.100	-	-	LDO	PTHR12166
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3090
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810