DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cadps and UNC13A

DIOPT Version :9

Sequence 1:	NP_001245439.1	Gene:	Cadps / 49968	FlyBaseID:	FBgn0053653	Length:	1534	Species:	Drosophila melanogaster
Sequence 2:	NP_001073890.2	Gene:	UNC13A / 23025	HGNCID:	23150	Length:	1703	Species:	Homo sapiens

Alignment Length:	1468	Identity:	250/1468 - (17%)
Similarity:	446/1468 - (30%)	Gaps:	596/1468 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LGSTSNKIEQICGNRADTGNLEVPSNGIPSGISQETLNQSVGSSRANSLPRPLSPSPSLTSEKHE 149
            |||.:.:.:.......|...:.:|. ..|....:..:..:.....|...|:|.:|.....:|:..
Human   355 LGSYAQREDVAVAEPKDFKRISLPP-AAPGKEDKAPVAPTEAPDMAKVAPKPATPDKVPAAEQIP 418

  Fly   150 TAEPHGKHE----REEEE-------------------RKRRIQLYVFISRCISYPFNAKQPTDMT 191
            .|||....|    ||:||                   .|.|:||.           .|:...:|:
Human   419 EAEPPKDEESFRPREDEEGQEGQDSMSRAKANWLRAFNKVRMQLQ-----------EARGEGEMS 472

  Fly   192 K---------------------RQTK----ISKQQLEIITQRFQAFLKGETQIMADEAFQNAVQS 231
            |                     |:.|    :|...:.::..|    ..|.|..:|.....|....
Human   473 KSLWFKGGPGGGLIIIDSMPDIRKRKPIPLVSDLAMSLVQSR----KAGITSALASSTLNNEELK 533

  Fly   232 YHDVFLKSERVLKMVQSGASSQHDFREVFRNNIEKRVRSLP----EIDGL----------SKETV 282
            .| |:.|:.:.| :.....::.|:| ||:       ..:.|    |.:||          ..|..
Human   534 NH-VYKKTLQAL-IYPISCTTPHNF-EVW-------TATTPTYCYECEGLLWGIARQGMRCTECG 588

  Fly   283 LTSWMAKFDII----LKGTGEEDSKRPSRMQQSLNSELIL---------SKEQLYDMFQQILLVK 334
            :.......|::    |:...|:.||..:. .::.|..::|         :|.:::::.|:|..|.
Human   589 VKCHEKCQDLLNADCLQRAAEKSSKHGAE-DRTQNIIMVLKDRMKIRERNKPEIFELIQEIFAVT 652

  Fly   335 KFEHQILFNALMLDSADEQAAAIRRE-LDGRMQRVGEMEKNRKLMPKFVLKEMESLYVEELKSSI 398
            |..|            .:|..|:::. |||..:                         ...|.||
Human   653 KTAH------------TQQMKAVKQSVLDGTSK-------------------------WSAKISI 680

  Fly   399 NLLMANLESLPVSKGNMDSKYGLQKLKRYNHSTPSFLKLILRSHGSLSKLEGDSEDGSTQLTKLD 463
            .::.|.               |||...:...|.|
Human   681 TVVCAQ---------------GLQAKDKTGSSDP------------------------------- 699

  Fly   464 VVLTFQLEVIVMEVKGLKSLAPNRIVYCTMEVENGEKLQTDQAEASKPMWDTQGDFTTTHPLPVV 528
                                      |.|::|...:|..........|:|:....|...:....:
Human   700 --------------------------YVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRI 738

  Fly   529 KVKLYTENPGMLAL--------EDKELGKVTLKPTPLSSKSPEWHRMIVPKNLPDQDIRIKIACR 585
            ||:::.|:..:.:.        .|..||:..::...||.:...|:.:       |:        |
Human   739 KVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNL-------DK--------R 788

  Fly   586 LDKPLNMKHCGYLYAIGKSVWKKWKRRYFVLVQVSQYTFAMCSYKEKKSEPSEMMQLDGYTVDYI 650
            .||.          |:..::      |..:.|::.         .|:|..|        |.|.|
Human   789 TDKS----------AVSGAI------RLHISVEIK---------GEEKVAP--------YHVQY- 819

  Fly   651 EAASANLMFGIDLNGGRYFFNAVREGDSISFACDDENECSLWVMAMYRATGQSHKPTPPITQDKN 715
                                           .|..||....                  :|..:|
Human   820 -------------------------------TCLHENLFHF------------------VTDVQN 835

  Fly   716 SAMSKI-QGDADKARKHGMEDFISTDPCTFDHATLFKTLQNLTLEYRLNDPYASLGWFSPGQVFV 779
            :.:.|| ....|.|.|           ..:|     :|.|.                       :
Human   836 NGVVKIPDAKGDDAWK-----------VYYD-----ETAQE-----------------------I 861

  Fly   780 LDEYCARYGVRGCY-----------RHLC-----YLSDLLD--RAEKQHMIDPTLIHYSFAFCAS 826
            :||:..||||...|           :::|     .:|.||.  .|...|....|.:..|..|.||
Human   862 VDEFAMRYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAAS 926

  Fly   827 HVHGNRPDGVGSITHEEKEKFSEIKERLRQLLEFQITNFRYCFPFGRPEGA--LKATLSLLE--- 886
            :.              .||:|.::.::|...|...::.:|..||...||..  ||:|:.||.
Human   927 NF--------------GKERFVKLLDQLHNSLRIDLSMYRNNFPASSPERLQDLKSTVDLLTSIT 977

  Fly   887 --RVLMKDIVTPVPPEEVRQMIKKSLETAALVNYTRLSNKA--------KIDEDLRGDVIV---- 937
              |:.::::.:   |....|::|..::......|..:.|..        :.|...:|:|:.
Human   978 FFRMKVQELQS---PPRASQVVKDCVKACLNSTYEYIFNNCHELYSREYQTDPAKKGEVLPEEQG 1039

  Fly   938 PAPKKLEDLIHLAELCVDLLQQNEEHYGELRKHDKMDKKKLLKEDEDVSGGHNESEVDLIDSTGL 1002
            |:.|.|:....|..|.|.::::::..|....                     |:...:|  :.|.
Human  1040 PSIKNLDFWSKLITLIVSIIEEDKNSYTPCL---------------------NQFPQEL--NVGK 1081

  Fly  1003 ISASELATAASTDGSSFRYCMPTH-----------------------------AVYTPPVPTAFA 1038
            |||..:....:.|   .:|.|..|                             ..:...||...|
Human  1082 ISAEVMWNLFAQD---MKYAMEEHDKHRLCKSADYMNLHFKVKWLYNEYVTELPAFKDRVPEYPA 1143

  Fly  1039 WFSDLLV------------------------------EHAEIFWSLFAVDMDRVLSE-------- 1065
            ||...::                              |||  .:|...||:...|::
Human  1144 WFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSEHA--LFSCSVVDVFSQLNQSFEIIKKL 1206

  Fly  1066 QAPDTWDSFPLFQILNDYLRTDDNLRNGRFHQHLRDTFAPLVVRYVDLMESSIAQSIHKGFEKER 1130
            :.||.       ||:..|:|        ||.:    |.:.::::|.|::....|....|  |||:
Human  1207 ECPDP-------QIVGHYMR--------RFAK----TISNVLLQYADIISKDFASYCSK--EKEK 1250

  Fly  1131 WESKGINAALNPAALNNAAQALNTAALNPSMILCGKK--DQVNFYVPKLPKQSNSTAANDEMRNG 1193
                      .|..|.|..|.|..........:.||:  .:.:..:.:|..:.|:..  ||:...
Human  1251 ----------VPCILMNNTQQLRVQLEKMFEAMGGKELDAEASDILKELQVKLNNVL--DELSRV 1303

  Fly  1194 CATSEDLFWKLDALQSFIRDLHWPDAEFRQHLEQRLKMMAVDMIEQCIQRTDSSFQSWLKKNIAF 1258
            .|||                       |:.|:|:.:|.|. |::.| ::.|.:
Human  1304 FATS-----------------------FQPHIEECVKQMG-DILSQ-VKGTGN------------ 1331

  Fly  1259 ISTDYILPSEMCAMVNVILDAKNQSFKLTTIDGIDLYKFHAKIDDQIDKANVAMTQGLSGKLMSV 1323
                  :|:..|:  :|..||.|....:..:...:|..| |||.::.....|  .:.|...:|:.
Human  1332 ------VPASACS--SVAQDADNVLQPIMDLLDSNLTLF-AKICEKTVLKRV--LKELWKLVMNT 1385

  Fly  1324 LESTLSKLARYDEGSLIGSILSFTNVSSSGKDLGQGYV 1361
            :|.|: .|....:.::||::|     ...||.|.:|.|
Human  1386 MEKTI-VLPPLTDQTMIGNLL-----RKHGKGLEKGRV 1417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cadps	NP_001245439.1	PH_CADPS	585..711	CDD:269940	15/125 (12%)
		PH	593..699	CDD:278594	12/105 (11%)
		DUF1041	904..1066	CDD:283860	36/240 (15%)
UNC13A	NP_001073890.2	C2A_Munc13	1..127	CDD:176040
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..445		19/90 (21%)
		C1	554..603	CDD:237996	10/56 (18%)
		C2B_Munc13	676..802	CDD:175993	31/228 (14%)
		DUF1041	994..1102	CDD:283860	23/133 (17%)
		Membr_traf_MHD	1347..1508	CDD:287505	19/80 (24%)
		C2C_Munc13	1546..1665	CDD:176041
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000