DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cadps and Unc13b

DIOPT Version :9

Sequence 1:	NP_001245439.1	Gene:	Cadps / 49968	FlyBaseID:	FBgn0053653	Length:	1534	Species:	Drosophila melanogaster
Sequence 2:	NP_001371035.1	Gene:	Unc13b / 22249	MGIID:	1342278	Length:	4285	Species:	Mus musculus

Alignment Length:	1815	Identity:	333/1815 - (18%)
Similarity:	537/1815 - (29%)	Gaps:	711/1815 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PSSSEEEGEDDAVPNVSSKGRLTNTTKGTSAVSIIGGSAGSVVGSNIPVSGSNTDLIGNQRQSNI 68
            |.::::|      |:||           ||...  .||:...|||.:|.|.............:.
Mouse  2450 PETNKQE------PSVS-----------TSCFQ--SGSSRDPVGSILPKSLPGEAACAGLNSESA 2495

  Fly    69 SSICNRNDVG--------------------NISVA--------ALGSTSNKIEQICG----NRAD 101
            .|.|:...|.                    |||.:        .|.:||:..|...|    :.:|
Mouse  2496 LSACSITVVDAKSESDPLTDDPKLIPEMEKNISESISEPPCFEVLATTSSVSEDDMGQGILSLSD 2560

  Fly   102 TGNLEVPSNGIPSGISQE-----------TLNQSVGSSRANSLPRPLSPSPSLTSEKHETAEPHG 155
            .|::     |:..|...|           |..||..:..|..||....|...|..|.....||..
Mouse  2561 EGDM-----GLLQGTDTEASLEAEHILLPTQLQSDPACIAEELPPSSQPLLELEPEPEPEPEPEP 2620

  Fly   156 KHEREEEERKRRIQLYVFISRCISYPFNAKQPTDMTKRQTKISKQQLEIITQRFQAFLKGETQIM 220
            :.|.|.|..                |....:|..:|   ...:::...::|...:..:....:..
Mouse  2621 EPEPEPEPE----------------PEPEPEPELLT---ASTNQEYFGLVTTSVETSISLFDEAG 2666

  Fly   221 ADEAFQNAVQSYHDVFLKSERVLKMVQSGASSQH----------DFREVFRNNIE-KRVRSLPEI 274
            |.|......|.||...|:.|.||.:.:|  ||.|          ...|..|...| ..:.|.|::
Mouse  2667 ASENTTLETQGYHSCPLQEEPVLCLKES--SSIHHAPKDPPVAPQETEQTRPRFEIPNMASWPKL 2729

  Fly   275 ----------------------DGLSKETVLTSWMAKFDIILKGTGE------------------ 299
                                  ..::.||.|.|...|...:.:|..|
Mouse  2730 HFPSTPDHGKTLSSIFNPSSSSGNMAAETGLMSGFKKLSTLFEGASEGKGVILGNDPKLVFGKKL 2794

  Fly   300 --------EDSKRPSRMQQ--------SLNSELILSK---------------------------- 320
                    |:...|.:|..        |.:.:||:||
Mouse  2795 DLSFPWSKENKGDPEQMPAKSSPVLVVSDDQDLIISKANKISESSQVPSGSPKSANICTLPSGTT 2859

  Fly   321 EQLY----DMFQQILLVKKFEHQILFNALMLDSADEQAAAIRRELDGRMQRVGEMEKNRKLMPKF 381
            |||.    |..|::....:.|.|:.|      ||.|:.......|.| ..|..|..|........
Mouse  2860 EQLVAKPSDCAQELSKSGEVERQLEF------SAPEEHWGEDSNLSG-SARPSEKHKEEHCAQPA 2917

  Fly   382 VLKEMES-----------LYVEELKSSINLLMANLESLPVSKGNMDSKYG-----------LQKL 424
            ..:||.:           :..|:.|.::.      ...|.|    .|:||           |.:|
Mouse  2918 KQEEMSASTSSILNVGQLVIPEDTKETVT------NKSPTS----SSRYGSSCNVSQGSSLLSEL 2972

  Fly   425 KRYN------------HSTPSFLKLILRSHGSLSKLEGDSEDGSTQLTK-LDVVLTFQLEVIVME 476
            .:|:            ||:        .|:|||||   |.:.|..:..| |:|....:.|. ..|
Mouse  2973 DQYHEQDDDGRERDSIHSS--------HSYGSLSK---DGQAGLGEQEKALEVTCESEKEK-TGE 3025

  Fly   477 VKGLKSLA----PNRIVYCTMEVENGE--------------------------KLQ----TDQAE 507
            .|.::..|    |:.:|.....|...:                          :||    :|..:
Mouse  3026 SKEMRDDATIHPPSDLVLHKDHVLGPQESLPEETASSPFTQARAHWFRAVTKVRLQLQEISDDGD 3090

  Fly   508 ASKPMW------------DTQGDFTTTHPLPVV---------KVKLYTENPGMLALEDKELGKVT 551
            .|.|.|            |:..|.....|||:|         |..:.:......:|:|:||....
Mouse  3091 PSLPQWLPEGPAGGLYGIDSMPDLRRKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHV 3155

  Fly   552 LKPT------PLSSKSPE----WHRMI-------------------------VPKNLPDQDI--- 578
            .|.|      |:|..:|.    |....                         |..:...||:
Mouse  3156 YKKTLQALIYPISCTTPHNFEVWSATTPTYCYECEGLLWGLARQGMRCSECGVKCHEKCQDLLNA 3220

  Fly   579 ----------------------------RIKIACRLDKP------------LNMKHCGYLYAIGK 603
                                        |:||..| :||            ..:.|...:..:.:
Mouse  3221 DCLQRAAEKSSKHGAEDRTQNIIMAMKDRMKIRER-NKPEIFEVIRDVFTVSKVAHVQQMKTVKQ 3284

  Fly   604 SV---WKKWKRRYFVLVQVSQYTFAMCSYKEK--KSEPSEMMQLDGYTVDYIEAASANLMFGIDL 663
            ||   ..||..:..:.|..:|...|    |:|  .|:|...:|: |.|     ......:|| :|
Mouse  3285 SVLDGTSKWSAKITITVVCAQGLQA----KDKTGSSDPYVTVQV-GKT-----KKRTKTIFG-NL 3338

  Fly   664 N---GGRYFFNAVREGDSISFACDDEN-------------------------------ECSLWVM 694
            |   ..::.|......|.|.....||:                               |..:|
Mouse  3339 NPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVW-- 3401

  Fly   695 AMYRATGQSHKPTPPITQDKNSAMS---------KIQGDADKARKHGMEDFISTDPCTFDHATLF 750
              |....::.|          ||:|         :|:|:...|..|..        .|..|..||
Mouse  3402 --YNLEKRTDK----------SAVSGAIRLQISVEIKGEEKVAPYHVQ--------YTCLHENLF 3446

  Fly   751 KTLQNL-------TLEYRLNDPYASLGWFSPGQVFVLDEYCARYGVRGCY-----------RHLC 797
            ..|.::       ..|.|.:|.:..  :|......::||:..|||:...|           :::|
Mouse  3447 HYLTDIQGSGGVWIPEARGDDAWKV--YFDETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMC 3509

  Fly   798 -----YLSDLLD--RAEKQHMIDPTLIHYSFAFCASHVHGNRPDGVGSITHEEKEKFSEIKERLR 855
                 .:|.||.  .|...|....|.:..|..|.||:.              .||:|.::.::|.
Mouse  3510 PGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNF--------------GKERFVKLLDQLH 3560

  Fly   856 QLLEFQITNFRYCFPFGRPEGA--LKATLSLLE-----RVLMKDIVTPVPPEEVRQMIKKSLETA 913
            ..|...::.:|..||.|.||..  ||:|:.||.     |:.::::.:   |....|::|..::..
Mouse  3561 NSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSITFFRMKVQELQS---PPRASQVVKDCVKAC 3622

  Fly   914 ALVNYTRLSNKAKIDEDLRGDVIVPAPKKLEDLIHLAELCVDL------LQQN--EEHYGELRKH 970
            ....|..:.|.                            |.||      ||:.  ||....:|..
Mouse  3623 LNSTYEYIFNN----------------------------CHDLYSHQYQLQEQPLEEPGPSIRNL 3659

  Fly   971 DKMDK-----KKLLKEDEDVSGGHNESEVDLIDSTGLISASELATAASTDGSSFRYCMPTHAVYT 1030
            |...|     ..:::||::                                           .||
Mouse  3660 DFWPKLITLIVSIIEEDKN-------------------------------------------SYT 3681

  Fly  1031 PPVPTAFAWFSDLLVEHAEIFWSLFAVDMDRVLSEQAPDTWDS--------FPLFQILNDYLRTD 1087
             ||.:.|....::....||:.|.|||.||...|.|...|....        |.:..:.|:|:| |
Mouse  3682 -PVLSQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDRLCKSADYMNLHFKVKWLHNEYVR-D 3744

  Fly  1088 DNLRNGRFHQHLRDTFAPLVVRYVDLMESSIAQSIHKGFEKERWESKGINAALNPAALNNAAQAL 1152
            .....|:..:: ...|...|::::|..|....:.:....|::
Mouse  3745 LPALQGQVPEY-PAWFEQFVLQWLDENEDVSLEFLRGALERD----------------------- 3785

  Fly  1153 NTAALNPSMILCGKKDQVNFYVPKLPKQSNSTAANDEMRNGCATSEDLFWKLDALQSFIRDLHWP 1217
                         |||..        :|::..|.     ..|:. .|:|.:|:.....||.|..|
Mouse  3786 -------------KKDGF--------QQTSEHAL-----FSCSV-VDVFTQLNQSFEIIRKLECP 3823

  Fly  1218 DAEFRQHLEQRLKMMAVDMIEQCIQRTDSSFQSWLKKNIAFISTDYILPSEMCAMVNVILDAKNQ 1282
            |.....|..:|        ..:.|.:....:...|.||.....|...||   |.::|.:...:.|
Mouse  3824 DPNILAHYMRR--------FAKTIGKVLMQYADILSKNFPAYCTKERLP---CILMNNMQQLRVQ 3877

  Fly  1283 SFKLTTIDGIDLYKFHAKIDDQIDKANVAMTQGLSGKLMSVLESTLSKL------ARYDE----- 1336
            ..|:          |.|....::|.......:.|..||.:||:. ||.:      .|.||
Mouse  3878 LEKM----------FEAMGGKELDSEAADSLKELQVKLNTVLDE-LSMVFGNSFQVRIDECVRQM 3931

  Fly  1337 GSLIGSILSFTNVSSSGK-DLGQGYVNFFRNNMDQVRG---------------KIADDLW 1380
            ..::|.:....|.|.:.: .:.|...:..|..||.:.|               ::..:||
Mouse  3932 ADILGQVRGTGNASPNARASVAQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELW 3991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cadps	NP_001245439.1	PH_CADPS	585..711	CDD:269940	31/176 (18%)
		PH	593..699	CDD:278594	27/144 (19%)
		DUF1041	904..1066	CDD:283860	30/174 (17%)
Unc13b	NP_001371035.1	C2A_Munc13	1..127	CDD:176040
		C1_Munc13-2-like	3154..3235	CDD:410409	9/80 (11%)
		C2B_Munc13	3295..3421	CDD:175993	26/150 (17%)
		DUF1041	3613..3716	CDD:399355	30/174 (17%)
		Membr_traf_MHD	3959..4095	CDD:402254	6/33 (18%)
		C2C_Munc13	4133..4252	CDD:176041
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000