Protein Alignment Cadps and cadps

DIOPT Version :9

• Sequence 1: NP_001245439.1
• Gene: Cadps / 49968
• FlyBaseID: FBgn0053653
• Length: 1534
• Species: Drosophila melanogaster
• Sequence 2: XP_012815879.1
• Gene: cadps / 100124730
• XenbaseID: XB-GENE-5755926
• Length: 1356
• Species: Xenopus tropicalis
• Alignment Length: 1559
• Identity: 822/1559 - (52%)
• Similarity: 1023/1559 - (65%)
• Gaps: 283/1559 - (18%)

  Fly     1 MIDPSSSEEEGEDDAV--PNVSSKGRLTNTTKGTSAVSIIGGSAGSVVGSNIPVSGSNTDLIGNQ 63
            |:|||||||| .|:.|  |.:..                  |.|        |.:|:.   :...
 Frog     1 MLDPSSSEEE-SDEVVEEPEIKE------------------GQA--------PTTGTR---LSPS 35

  Fly    64 RQSNISSICNRNDVGNISVAALGSTSNKIEQICGNRADTGNLEVPSNGIPSGISQETLNQSVGSS 128
            |.|:.|                                 |.|:                   .||
 Frog    36 RTSDSS---------------------------------GGLQ-------------------PSS 48

  Fly   129 RANSLPRPLSPSPSLTSEKHETAEPHGKHEREEEERKRRIQLYVFISRCISYPFNAKQPTDMTKR 193
            |::|: ||.|||||:.|||.:  |...:.::|||||||::|||||:.|||:|||||||||||.:|
 Frog    49 RSSSV-RPSSPSPSVVSEKEK--EELERLQKEEEERKRKLQLYVFVMRCIAYPFNAKQPTDMARR 110

  Fly   194 QTKISKQQLEIITQRFQAFLKGETQIMADEAFQNAVQSYHDVFLKSERVLKMVQSGASSQHDFRE 258
            |.|||||||:.:..|||||..|||||:|||||.||||||::|||||:||.:|||||..|.:|.||
 Frog   111 QQKISKQQLQTVKDRFQAFFNGETQIVADEAFMNAVQSYYEVFLKSDRVARMVQSGGCSANDSRE 175

  Fly   259 VFRNNIEKRVRSLPEIDGLSKETVLTSWMAKFDIILKGTGEED-SKRPSRMQQSLNSELILSKEQ 322
            ||:.:||||||||||||||||||||:|||||||.|.:  |||| .|:.:||..|..|||||||||
 Frog   176 VFKKHIEKRVRSLPEIDGLSKETVLSSWMAKFDAIYR--GEEDPRKQQARMTASAASELILSKEQ 238

  Fly   323 LYDMFQQILLVKKFEHQILFNALMLDSADEQAAAIRRELDGRMQRVGEMEKNRKLMPKFVLKEME 387
            ||:||||||.:||||||:|:||..||:.|||||.||||||||:|...::.:.|| .||||.||||
 Frog   239 LYEMFQQILGIKKFEHQLLYNACQLDNPDEQAAQIRRELDGRLQMADQIARERK-FPKFVSKEME 302

  Fly   388 SLYVEELKSSINLLMANLESLPVSKGNMDSKYGLQKLKRYNHSTPSFLKLILRSHGSLSKLEGDS 452
            ::|:||||||:|||||||||:|||||.  |::.|||||| :|:| |.:.:              .
 Frog   303 NMYIEELKSSVNLLMANLESMPVSKGG--SEFKLQKLKR-SHNT-SIIDM--------------G 349

  Fly   453 EDGSTQLTKLDVVLTFQLEVIVMEVKGLKSLAPNRIVYCTMEVENGEKLQTDQAEASKPMWDTQG 517
            |:...||:|.||||.|.|||::|||:||||||||||||||||||.||||||||||||||||.|||
 Frog   350 EENENQLSKSDVVLAFSLEVVIMEVQGLKSLAPNRIVYCTMEVEGGEKLQTDQAEASKPMWGTQG 414

  Fly   518 DFTTTHPLPVVKVKLYTENPGMLALEDKELGKVTLKPTPLSSKSPEWHRMIVPKNLPDQDIRIKI 582
            ||:|||.||.|||||:||:.|:|||||||||:|.|.|||.|.|..|||:|.:.||.||.|::||:
 Frog   415 DFSTTHALPAVKVKLFTESTGVLALEDKELGRVVLHPTPNSPKQSEWHKMTISKNCPDHDLKIKL 479

  Fly   583 ACRLDKPLNMKHCGYLYAIGKSVWKKWKRRYFVLVQVSQYTFAMCSYKEKKSEPSEMMQLDGYTV 647
            |.|:|||.||||||||:||||:|||:||:|:||||||||||||||||:|||:||.|::|||||||
 Frog   480 AVRMDKPQNMKHCGYLWAIGKNVWKRWKKRFFVLVQVSQYTFAMCSYREKKAEPQELLQLDGYTV 544

  Fly   648 DYIEAASANLMFGIDLNGGRYFFNAVREGDSISFACDDENECSLWVMAMYRATGQSHKPTPPITQ 712
            ||.:....       |.|||.|||||:|||::.||.|||.:..|||.||||||||||||.||...
 Frog   545 DYTDPQPG-------LEGGRSFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSHKPVPPTQV 602

  Fly   713 DKNSA-----------MSKIQG--DADKARKHGMEDFISTDPCTFDHATLFKTLQNLTLEYRLND 764
            .|.:|           :|:..|  |||:|:||||::|||::||.|||||||:.:|.|||::||||
 Frog   603 QKLNAKGGNVPQLDAPISQFSGLKDADRAQKHGMDEFISSNPCNFDHATLFEMVQRLTLDHRLND 667

  Fly   765 PYASLGWFSPGQVFVLDEYCARYGVRGCYRHLCYLSDLLDRAEKQHMIDPTLIHYSFAFCASHVH 829
            .|:.||||||||||||||||||||||||:||||||.|||:|||...|:||||:||||||||||||
 Frog   668 SYSCLGWFSPGQVFVLDEYCARYGVRGCHRHLCYLGDLLERAENGSMVDPTLLHYSFAFCASHVH 732

  Fly   830 GNRPDGVGSITHEEKEKFSEIKERLRQLLEFQITNFRYCFPFGRPEGALKATLSLLERVLMKDIV 894
            ||||||:|::|.||||:|.|||||||.|||.|||:||||||||||||||||||||||||||||||
 Frog   733 GNRPDGIGTVTVEEKERFEEIKERLRLLLENQITHFRYCFPFGRPEGALKATLSLLERVLMKDIV 797

  Fly   895 TPVPPEEVRQMIKKSLETAALVNYTRLSNKAKIDEDLR--------------------------- 932
            ||||.|||:.:|:|.||.||||||||||..|||:...|
 Frog   798 TPVPQEEVKNVIRKCLEQAALVNYTRLSEYAKIEGKKREMYEHPVFCLASQVMDLTIQNQKDAEN 862

  Fly   933 -GDVIVPAPKKLEDLIHLAELCVDLLQQNEEHYGELRKHDKMDKKKLLKEDEDVSGGHNESEVDL 996
             |.::.|| |||||.|.||||.:::|||||||:.|.::
 Frog   863 VGRLVTPA-KKLEDTIRLAELVIEVLQQNEEHHAEGKE--------------------------- 899

  Fly   997 IDSTGLISASELATAASTDGSSFRYCMPTHAVYTPPVPTAFAWFSDLLVEHAEIFWSLFAVDMDR 1061
                                                   ||||:|||:|||||.|.||||||||.
 Frog   900 ---------------------------------------AFAWWSDLMVEHAETFLSLFAVDMDA 925

  Fly  1062 VLSEQAPDTWDSFPLFQILNDYLRTDDNLRNGRFHQHLRDTFAPLVVRYVDLMESSIAQSIHKGF 1126
            .|..|.||:||||||||::||:||:|.||.||:||:||:|.|||||||||||||||||||||:||
 Frog   926 ALEVQPPDSWDSFPLFQLINDFLRSDYNLCNGKFHKHLQDLFAPLVVRYVDLMESSIAQSIHRGF 990

  Fly  1127 EKERWES-KGINAALNPAALNNAAQALNTAALNPSMILCGKKDQVNFYVPKLPKQSNST--AAND 1188
            |:|.||. |.:.:.|....|.|    :|...:..::       .||  :|::|..|..:  ||..
 Frog   991 ERESWEPVKSLTSNLPNVNLPN----VNLPKVPVTL-------PVN--LPQMPSFSAPSWMAAIY 1042

  Fly  1189 EMRNGCATSEDLFWKLDALQSFIRDLHWPDAEFRQHLEQRLKMMAVDMIEQCIQRTDSSFQSWLK 1253
            :..||.||||||||||||||:||||||||:.||.:|||||||:||.||||.|::||..:|:..|:
 Frog  1043 DSDNGSATSEDLFWKLDALQTFIRDLHWPEEEFGKHLEQRLKLMASDMIESCVKRTRIAFEVKLQ 1107

  Fly  1254 KNIAFISTDYILPSEMCAMVNVILDAKNQSFKLTTIDGIDLYKFHAKIDDQIDKANVAMTQGLSG 1318
            |...  |||:.:|..:|.|.||::|||.||.||.:::....:::|::||:.|::....|...|..
 Frog  1108 KTSR--STDFRVPQSICTMFNVMVDAKAQSTKLCSMEMGQEHQYHSQIDELIEETVKEMITLLVA 1170

  Fly  1319 KLMSVLESTLSKLARYDEGSLIGSILSFT--------NVSSSGKDLGQGYVNFFRNNMDQVRGKI 1375
            |.:::||..||||:|||||:|..|.||||        :|...|.||...||.|.|::.|.:|.|:
 Frog  1171 KFVTILEGVLSKLSRYDEGTLFSSFLSFTVKAASKYVDVPKPGMDLADAYVTFVRHSQDVLRDKV 1235

  Fly  1376 ADDLWT----------------LHFFEQWYSQQINMLCNWLSERVDHALHYAQVASISHIIKKIY 1424
            .::::.                |...||||:..:|::|.||::|:|..||..|:.::..::||.|
 Frog  1236 NEEIYIERLFDKRLDGNSSVMYLRILEQWYTSSMNVVCTWLTDRMDLQLHIYQLKTLIRVVKKTY 1300

  Fly  1425 SDFELQGVLEDKLNSKAYQAVAQRMATEEATCA---------LTMPDACEDEPCDEIREGEEED 1479
            .||.|||||:..||||.|..:..|:..||||.:         :||.|:.|        |.||:|
 Frog  1301 RDFRLQGVLDSTLNSKTYDTIRNRLTVEEATASVSEGGGLQGITMKDSDE--------EDEEDD 1356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cadps	NP_001245439.1	PH_CADPS	585..711	CDD:269940	87/125 (70%)
		PH	593..699	CDD:278594	70/105 (67%)
		DUF1041	904..1066	CDD:283860	61/189 (32%)
cadps	XP_012815879.1	PH_CADPS	482..601	CDD:269940	87/125 (70%)
		PH	490..589	CDD:278594	70/105 (67%)
		DUF1041	807..930	CDD:283860	61/189 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	536	1.000	Domainoid score	I275
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2755
Inparanoid	1	1.050	1405	1.000	Inparanoid score	I126
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138870at2759
OrthoFinder	1	1.000	-	-		FOG0004367
OrthoInspector	1	1.000	-	-		otm47662
Panther	1	1.100	-	-	LDO	PTHR12166
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3090
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160