DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cadps and cadpsb

DIOPT Version :9

Sequence 1:	NP_001245439.1	Gene:	Cadps / 49968	FlyBaseID:	FBgn0053653	Length:	1534	Species:	Drosophila melanogaster
Sequence 2:	XP_005166169.1	Gene:	cadpsb / 100001129	ZFINID:	ZDB-GENE-110621-2	Length:	1348	Species:	Danio rerio

Alignment Length:	1472	Identity:	786/1472 - (53%)
Similarity:	987/1472 - (67%)	Gaps:	216/1472 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 DTGNLEVPSNGIPSGISQETLNQSVGSSRAN-----------------SLPRPLSPSPSLTSEKH 148
            |..:.|..|:||....|:|.:....||||.:                 |..||.|||||..||:.
Zfish     3 DPSSSEEESDGIVEEESREVMAPQSGSSRISPSRTSESSDRLQPSSRGSSARPTSPSPSAASEEK 67

  Fly   149 ETAEPHGKHEREEEERKRRIQLYVFISRCISYPFNAKQPTDMTKRQTKISKQQLEIITQRFQAFL 213
            |..|   |.:|||||||:::|||||:.|||:|||||||||||.:||.||:||||:....||::||
Zfish    68 EDVE---KLQREEEERKKKLQLYVFVMRCIAYPFNAKQPTDMARRQLKITKQQLQTTKDRFESFL 129

  Fly   214 KGETQIMADEAFQNAVQSYHDVFLKSERVLKMVQSGASSQHDFREVFRNNIEKRVRSLPEIDGLS 278
            ||:|||:|||||.||||||.:|||||:||.||||:|..|..|.||||:.:|||||||||||||||
Zfish   130 KGDTQIVADEAFINAVQSYFEVFLKSDRVAKMVQTGGLSALDCREVFKRHIEKRVRSLPEIDGLS 194

  Fly   279 KETVLTSWMAKFDIILKGTGEEDSKRPSRMQQSLNSELILSKEQLYDMFQQILLVKKFEHQILFN 343
            |||||:|||||||.|.:| .|:..|...||..|..|||||||:|||:||||||.:||||||:|:.
Zfish   195 KETVLSSWMAKFDTIYRG-DEDPRKAQQRMTASAASELILSKDQLYEMFQQILGIKKFEHQLLYQ 258

  Fly   344 ALMLDSADEQAAAIRRELDGRMQRVGEMEKNRKLMPKFVLKEMESLYVEELKSSINLLMANLESL 408
            |..||:.|||||.||||||||:|...::.:..|.: |||.||||::|:||||||:|.|||||||:
Zfish   259 ACQLDNLDEQAAQIRRELDGRLQMADQIARAGKFL-KFVSKEMEAMYIEELKSSVNQLMANLESM 322

  Fly   409 PVSKGNMDSKYGLQKLKRYNHSTPSFLKLILRSHGSLSKLEGDSEDGSTQLTKLDVVLTFQLEVI 473
            |||||   .::.|||||| .|:|              |.::...|| ..||:|.||||:|.|||:
Zfish   323 PVSKG---GEFKLQKLKR-GHNT--------------SIIDMGQED-ENQLSKSDVVLSFTLEVV 368

  Fly   474 VMEVKGLKSLAPNRIVYCTMEVENGEKLQTDQAEASKPMWDTQGDFTTTHPLPVVKVKLYTENPG 538
            :|||:||||||||||||||||||.|:||||||||||||.|.||||||||||||.|||||:||:.|
Zfish   369 IMEVQGLKSLAPNRIVYCTMEVEGGQKLQTDQAEASKPTWGTQGDFTTTHPLPAVKVKLFTESTG 433

  Fly   539 MLALEDKELGKVTLKPTPLSSKSPEWHRMIVPKNLPDQDIRIKIACRLDKPLNMKHCGYLYAIGK 603
            :|||||||||:|.|.|||.|.|..|.|:|.|.|..||||::||:|.|:|||.|||.||||:|:||
Zfish   434 VLALEDKELGRVVLHPTPNSPKQAELHKMTVTKACPDQDLKIKLAVRMDKPQNMKACGYLWAVGK 498

  Fly   604 SVWKKWKRRYFVLVQVSQYTFAMCSYKEKKSEPSEMMQLDGYTVDYIEAASANLMFGIDLNGGRY 668
            :|||:||:|:||||||||||||||||:||||||.|::|||||||||.:....       |:|||.
Zfish   499 NVWKRWKKRFFVLVQVSQYTFAMCSYREKKSEPQELLQLDGYTVDYTDPQPG-------LDGGRA 556

  Fly   669 FFNAVREGDSISFACDDENECSLWVMAMYRATGQSHKPTPPITQDK-----------NSAMSKIQ 722
            |||||:|||::.||.|||.:..|||.||||||||||||.||....|           ::.:|:..
Zfish   557 FFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSHKPVPPTQVQKLNSKGKAAAQMDAPISQFS 621

  Fly   723 G--DADKARKHGMEDFISTDPCTFDHATLFKTLQNLTLEYRLNDPYASLGWFSPGQVFVLDEYCA 785
            |  |||:|:||||::|||.:||:||||:||:.:|.|||::||||.:|.|||||||||||||||||
Zfish   622 GLKDADRAQKHGMDEFISANPCSFDHASLFEMMQRLTLDHRLNDNFACLGWFSPGQVFVLDEYCA 686

  Fly   786 RYGVRGCYRHLCYLSDLLDRAEKQHMIDPTLIHYSFAFCASHVHGNRPDGVGSITHEEKEKFSEI 850
            |.|||||:||||||.|||:||:..|||||||:||||||||||||||||||:|::|.||||:|.||
Zfish   687 RNGVRGCHRHLCYLGDLLERADAGHMIDPTLLHYSFAFCASHVHGNRPDGLGTVTVEEKERFEEI 751

  Fly   851 KERLRQLLEFQITNFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPPEEVRQMIKKSLETAAL 915
            |||||.|||.||||||||||||||||||||||||||||||||||||||.|||:.:|:|.||.||.
Zfish   752 KERLRVLLENQITNFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKAVIRKCLEQAAQ 816

  Fly   916 VNYTRLSNKAKIDEDLR----------------------GDVIVPAPKKLEDLIHLAELCVDLLQ 958
            :||.|:::.|:::...|                      .::..|| ||||.:|.||||.:::|.
Zfish   817 INYQRITDYARVEGKKREMYDHPVYSLATQVMDLTIQNVANLATPA-KKLEHVIRLAELVIEVLH 880

  Fly   959 QNEEHYGELRKHDKMDKKKLLKEDEDVSGGHNESEVDLIDSTGLISASELATAASTDGSSFRYCM 1023
            ||::|:.|.                            .:.|||..|..|
Zfish   881 QNQDHHAEA----------------------------AVTSTGDQSGKE---------------- 901

  Fly  1024 PTHAVYTPPVPTAFAWFSDLLVEHAEIFWSLFAVDMDRVLSEQAPDTWDSFPLFQILNDYLRTDD 1088
                        ||||:|||:|||||.|.||:.||||..|..|:|::||||||||:|||:||||.
Zfish   902 ------------AFAWWSDLMVEHAENFLSLYGVDMDAALEIQSPESWDSFPLFQLLNDFLRTDY 954

  Fly  1089 NLRNGRFHQHLRDTFAPLVVRYVDLMESSIAQSIHKGFEKERWES-KGINAALNPAALNNAAQAL 1152
            :|.||:||:||:|.:||||||||||||||||||||:|||:|.||. |.:.:.|....|.|
Zfish   955 HLCNGKFHKHLQDLYAPLVVRYVDLMESSIAQSIHRGFERESWEPVKSLTSNLPNVNLPN----- 1014

  Fly  1153 NTAALNPSMILCGKKDQVNFYVPKLPK---------------QSNST----AANDEMRNGCATSE 1198
                             ||..:||:|.               .|.||    ||..:..||..|||
Zfish  1015 -----------------VNLQIPKVPNLPVPVAGLSVNLPQMPSFSTPSWMAAIYDSDNGSGTSE 1062

  Fly  1199 DLFWKLDALQSFIRDLHWPDAEFRQHLEQRLKMMAVDMIEQCIQRTDSSFQSWLKKNIAFISTDY 1263
            ||||||||||:||||||||:.||.:||:.|:|:|:.||||..::||..:|:|.|.|:..  |||:
Zfish  1063 DLFWKLDALQTFIRDLHWPEEEFAKHLDNRMKLMSSDMIETSVKRTRGAFESKLTKSSR--STDF 1125

  Fly  1264 ILPSEMCAMVNVILDAKNQSFKLTTIDGIDLYKFHAKIDDQIDKANVAMTQGLSGKLMSVLESTL 1328
            .:|..:|.|.||::|||:||.||..::.....::|::||:.|:::...|...|..|.:::|||.|
Zfish  1126 RIPLSLCTMFNVMVDAKDQSAKLCAMEMGQEKQYHSQIDELIEESVKDMIALLVAKFVAILESVL 1190

  Fly  1329 SKLARYDEGSLIGSILSFT--------NVSSSGKDLGQGYVNFFRNNMDQVRGKIADDLWTLHFF 1385
            :|::|||||:|..|.||||        .|...|.|:..|||.|.|::.|.:|.|:.::::....|
Zfish  1191 AKISRYDEGTLFSSFLSFTVKAASKYVEVPKPGMDVADGYVTFVRHSQDILRDKVNEEVYIERLF 1255

  Fly  1386 EQWYSQQINMLCNWLSERVDHALHYAQVASISHIIKKIYSDFELQGVLEDKLNSKAYQAVAQRMA 1450
            :|||:..:|:|..||:||:|..||..|:..:..|:||.|.||.|||||:..||||:|..|..|:.
Zfish  1256 DQWYTATMNLLATWLTERMDQQLHVYQLKILIRIVKKKYRDFRLQGVLDSTLNSKSYDTVRNRLT 1320

  Fly  1451 TEEATCALTMPDACEDEPCDEIREG----------EEEDNGD 1482
            .||||.:              :|||          :|||..|
Zfish  1321 LEEATAS--------------VREGGMQGISMKDSDEEDEED 1348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cadps	NP_001245439.1	PH_CADPS	585..711	CDD:269940	86/125 (69%)
		PH	593..699	CDD:278594	69/105 (66%)
		DUF1041	904..1066	CDD:283860	52/183 (28%)
cadpsb	XP_005166169.1	C2	364..447	CDD:214577	68/82 (83%)
		PH_CADPS	480..599	CDD:269940	86/125 (69%)
		PH	490..587	CDD:278594	68/103 (66%)
		DUF1041	805..932	CDD:283860	52/183 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581225
Domainoid	1	1.000	514	1.000	Domainoid score	I305
eggNOG	1	0.900	-	-		E1_KOG3543
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2755
Inparanoid	1	1.050	1407	1.000	Inparanoid score	I119
OMA	1	1.010	-	-		QHG48904
OrthoDB	1	1.010	-	-		D138870at2759
OrthoFinder	1	1.000	-	-		FOG0004367
OrthoInspector	1	1.000	-	-		otm26269
orthoMCL	1	0.900	-	-		OOG6_105391
Panther	1	1.100	-	-	O	PTHR12166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3090
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770