DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCS2alpha and MGAM

DIOPT Version :9

Sequence 1:	NP_652145.1	Gene:	GCS2alpha / 49953	FlyBaseID:	FBgn0027588	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001352622.1	Gene:	MGAM / 8972	HGNCID:	7043	Length:	2753	Species:	Homo sapiens

Alignment Length:	993	Identity:	258/993 - (25%)
Similarity:	397/993 - (39%)	Gaps:	194/993 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DPGNFKTCEQSSFCRRSRKIQGSGSKYALI-----PGTLNTYADSLTADLVNKENHHQFAFKLEA 81
            |||...|.:..:          :|:.:|..     |||..|...|....:||         :||
Human    53 DPGTTGTPDPGT----------TGTTHARTTGPPDPGTTGTTPVSAECPVVN---------ELE- 97

  Fly    82 LVGSTFRLQIDEKQPLRPRYRVEHALKGPTQA------------GRIRV---------QRETDGE 125
                  |:.....||             ||:|            |.:.|         ....:|.
Human    98 ------RINCIPDQP-------------PTKATCDQRGCCWNPQGAVSVPWCYYSKNHSYHVEGN 143

  Fly   126 IVITSEKNKAVIHGDPFRIDF---FENDVLVVSVNAKNWLYFEHLRQKAQEPTSHPAENENQQEQ 187
            :|.|:....|.:...|....|   .:|.:|.......|..:|: |..:.......|.|:......
Human   144 LVNTNAGFTARLKNLPSSPVFGSNVDNVLLTAEYQTSNRFHFK-LTDQTNNRFEVPHEHVQSFSG 207

  Fly   188 DAAVETPKAADTIDDPGAWEENFKSHH----DSKPYGP-----EAVALDFSFPAAKVLFGIPEHA 243
            :||.......:....|.:.:...:|::    ||. .||     :.:.|....|:..| :|:.||.
Human   208 NAAASLTYQVEISRQPFSIKVTRRSNNRVLFDSS-IGPLLFADQFLQLSTRLPSTNV-YGLGEHV 270

  Fly   244 DS-------------FILKSTSGTDPYRLYNLDVFEYVVDSKMALYGSVPVIYGHGAQRTAGVYW 295
            ..             |...:|...:...||....|...::....|              :.||:.
Human   271 HQQYRHDMNWKTWPIFNRDTTPNGNGTNLYGAQTFFLCLEDASGL--------------SFGVFL 321

  Fly   296 QNAAETWVDIQTSETNVVSSLVNFVSGSQKTPPPAAHFMSESGIVDAFIMLGPKPMDTFKQYAAL 360
            .|:....|.:|                    |.||..:.:..||:|.::.||..|....::|..|
Human   322 MNSNAMEVVLQ--------------------PAPAITYRTIGGILDFYVFLGNTPEQVVQEYLEL 366

  Fly   361 TGTHELPQLFALAYHQSRWNYNDERDVTSVSAKFDEYNIPMDTMWLDIEHTDGKRYFTWDKFKFP 425
            .|...||..:||.:|.||:.|....::..|..:.....:|.|....||::.|.:|.||:|...|.
Human   367 IGRPALPSYWALGFHLSRYEYGTLDNMREVVERNRAAQLPYDVQHADIDYMDERRDFTYDSVDFK 431

  Fly   426 HPLAMIKNLTELGRHLVVIVDPHIKRDNNYFFHRDCTDRG----YYVKTREG-NDYEGWCWPGAA 485
            .....:..|...|:.||:||||.|..:::........|||    .:|.:.:| ....|..|||..
Human   432 GFPEFVNELHNNGQKLVIIVDPAISNNSSSSKPYGPYDRGSDMKIWVNSSDGVTPLIGEVWPGQT 496

  Fly   486 SYPDFFNPVVREYYASQYALDKFQTVTADVMLWNDMNEPSVF-------------NGPEITAPKD 537
            .:||:.||....::..::.|  |........:|.||||.|.|             |.|..| |:.
Human   497 VFPDYTNPNCAVWWTKEFEL--FHNQVEFDGIWIDMNEVSNFVDGSVSGCSTNNLNNPPFT-PRI 558

  Fly   538 LIHY-----------GNW-EHRDVHNLYGHMHLMGSFAGLQQRDPNQRPFILTRAHFAGSQRYAA 590
            |..|           .:| :..|:|||||:...:.:....:...||:|.|||||:.||||.::||
Human   559 LDGYLFCKTLCMDAVQHWGKQYDIHNLYGYSMAVATAEAAKTVFPNKRSFILTRSTFAGSGKFAA 623

  Fly   591 IWTGDNFADWSHLQHSVKMCLTEAVAGFSFCGADVGAFFGNPDTELLERWYQTGAFLPFFRAHAH 655
            .|.|||.|.|..|:.|:...|...:.|....|.|:..|..:...||..||.|.|||.||.|.|..
Human   624 HWLGDNTATWDDLRWSIPGVLEFNLFGIPMVGPDICGFALDTPEELCRRWMQLGAFYPFSRNHNG 688

  Fly   656 IDTKRREPWLFPERTRQVIQNA----VIKRYSYLPLWYTAFYELELTGEPVIRPLLAQYPLDKEA 716
            ...|.::|..|  ....::.|:    :..||:.||..||.|:.....|:.|.||||.::..|...
Human   689 QGYKDQDPASF--GADSLLLNSSRHYLNIRYTLLPYLYTLFFRAHSRGDTVARPLLHEFYEDNST 751

  Fly   717 FGVDNQLLVQDRLLVRPVMQQGVSKVDVYFP-AIDDKKNGDWWYDVDT-YQRQERSGYVSVPVDD 779
            :.|..|.|....||:.||:.:|..||..|.| |:        |||.:| .|.:.|...|.:.:..
Human   752 WDVHQQFLWGPGLLITPVLDEGAEKVMAYVPDAV--------WYDYETGSQVRWRKQKVEMELPG 808

  Fly   780 FKIPVWQRGGSIVPKKERQRRASTLMLH-DPYTLIICLDRQGKASGSLYLDDEKSYAYRQGQRIH 843
            .||.:..|||.|.|  .:|...:||... :|..|||.||...:|.|.|:.|:.:: ......:::
Human   809 DKIGLHLRGGYIFP--TQQPNTTTLASRKNPLGLIIALDENKEAKGELFWDNGET-KDTVANKVY 870

  Fly   844 VNYEFAHDQ---LVNSFVGKPKYK---TLAWIERIVIAGLEKVPSSASITVNGV-SQQLEVLHHD 901
            :..||:..|   .||  :.:..||   .||:.| |.|.|.|: ||:.::..||| ||....:.:|
Human   871 LLCEFSVTQNRLEVN--ISQSTYKDPNNLAFNE-IKILGTEE-PSNVTVKHNGVPSQTSPTVTYD 931

  Fly   902 NTVVVRKPGVKMDVDFAI 919
            :.:   |..:..|:|..:
Human   932 SNL---KVAIITDIDLLL 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS2alpha	NP_652145.1	GH31_N	224..362	CDD:270212	28/150 (19%)
		Glyco_hydro_31	343..792	CDD:279404	151/484 (31%)
		GH31_GANC_GANAB_alpha	362..833	CDD:269889	161/507 (32%)
MGAM	NP_001352622.1	Trefoil	90..132	CDD:306572	12/70 (17%)
		NtCtMGAM_N	150..259	CDD:318956	19/110 (17%)
		GH31_N	252..368	CDD:270212	28/150 (19%)
		GH31_MGAM_SI_GAA	368..731	CDD:269888	114/367 (31%)
		PD	957..1000	CDD:197472
		NtCtMGAM_N	1014..1127	CDD:318956
		GH31_N	1113..1234	CDD:270212
		Glyco_hydro_31	1215..1717	CDD:307274
		PD	1853..1896	CDD:197472
		NtCtMGAM_N	1910..2023	CDD:318956
		GH31_N	2009..2130	CDD:270212
		Glyco_hydro_31	2111..2613	CDD:307274
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148180
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000251
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740