DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCS2alpha and RSW3

DIOPT Version :9

Sequence 1:	NP_652145.1	Gene:	GCS2alpha / 49953	FlyBaseID:	FBgn0027588	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001330435.1	Gene:	RSW3 / 836504	AraportID:	AT5G63840	Length:	948	Species:	Arabidopsis thaliana

Alignment Length:	953	Identity:	391/953 - (41%)
Similarity:	558/953 - (58%)	Gaps:	115/953 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 FKTCEQSSFCRRSR-KIQGSGSKYALIPGTLNTYADSLTADLVNKENHHQFAFKLEALVGS---- 85
            |::|:|:.||:|:| :..|:.|   ||.|.::.....|.|.|:.|..:.....:::.|:.|
plant    53 FRSCDQTPFCKRARSRTPGACS---LIVGDVSITDGDLVAKLLPKAPNQGDGDQIKPLILSLSVY 114

  Fly    86 ---TFRLQIDEKQPLRP---RYRVEHALKGPTQAGRIRVQR---ET------DGEIVITSEKNKA 135
               ..||:|||...|.|   |::|...:....:..:|.:|:   ||      ...:|..|:..:|
plant   115 KDGIVRLKIDEDHSLNPPKKRFQVPDVVVSEFEEKKIWLQKVATETISGDTSPSSVVYVSDGYEA 179

  Fly   136 VIHGDPFRIDFFEND---VLVVSVNAKNWLYFEHLRQKAQEPTSHPAENENQQEQDAAVETPKAA 197
            |:..|||.:...|..   ..|||:|:.....||.|.:|        .|.:|
plant   180 VVRHDPFEVYVREKSGDRRRVVSLNSHGLFDFEQLGRK--------TEGDN-------------- 222

  Fly   198 DTIDDPGAWEENFKSHHDSKPYGPEAVALDFSFPAAKVLFGIPEHADSFILKSTSG-----TDPY 257
                    |||.|::|.||:|.||::::.|.||..:..::||||||.||.||.|.|     ::||
plant   223 --------WEEKFRTHTDSRPSGPQSISFDVSFYDSSFVYGIPEHATSFALKPTKGPGVEESEPY 279

  Fly   258 RLYNLDVFEYVVDSKMALYGSVPVIYGHG-AQRTAGVYWQNAAETWVDIQTSETNVVSSLVNFVS 321
            ||:|||||||..:|...||||:|.:..|| :.:|:|.:|.||||..:|:          |.|...
plant   280 RLFNLDVFEYDHESPFGLYGSIPFMVSHGKSGKTSGFFWLNAAEMQIDV----------LANGWD 334

  Fly   322 GSQKTPPPAAH------FMSESGIVDAFIMLGPKPMDTFKQYAALTGTHELPQLFALAYHQSRWN 380
            .......|::|      :|||:||||.|..:||:|.|..||||::|||..:|||||..|||.|||
plant   335 AESGISLPSSHSRIDTFWMSEAGIVDTFFFVGPEPKDVVKQYASVTGTSAMPQLFATGYHQCRWN 399

  Fly   381 YNDERDVTSVSAKFDEYNIPMDTMWLDIEHTDGKRYFTWDKFKFPHPLAMIKNLTELGRHLVVIV 445
            |.||.||..|.:||||::||.|.:||||||||||||||||...||||..|.|.|...||.:|.||
plant   400 YKDEEDVAQVDSKFDEHDIPYDVLWLDIEHTDGKRYFTWDSVLFPHPEEMQKKLAAKGRKMVTIV 464

  Fly   446 DPHIKRDNNYFFHRDCTDRGYYVKTREGNDYEGWCWPGAASYPDFFNPVVREYYASQYALDKFQT 510
            |||||||::||.|::.|..|||||...|.|::||||||::||.|..:|.:|:::..:::...:..
plant   465 DPHIKRDDSYFLHKEATQMGYYVKDSSGKDFDGWCWPGSSSYIDMLSPEIRKWWGGRFSYKNYVG 529

  Fly   511 VTADVMLWNDMNEPSVFNGPEITAPKDLIHYGNWEHRDVHNLYGHMHLMGSFAGLQQRDPNQ-RP 574
            .|..:..||||||||||||||:|.|:|.:|.|..|||:|||.||:...|.:..||..|:..: ||
plant   530 STPSLYTWNDMNEPSVFNGPEVTMPRDALHVGGVEHREVHNAYGYYFHMATSDGLVMREEGKDRP 594

  Fly   575 FILTRAHFAGSQRYAAIWTGDNFADWSHLQHSVKMCLTEAVAGFSFCGADVGAFFGNPDTELLER 639
            |:|:||.|.|:|||.|||||||.|:|.||:.|:.|.||..:.|.:|.|||:|.|||||:.|||.|
plant   595 FVLSRAIFPGTQRYGAIWTGDNTAEWEHLRVSIPMILTLGLTGITFSGADIGGFFGNPEPELLVR 659

  Fly   640 WYQTGAFLPFFRAHAHIDTKRREPWLFPERTRQVIQNAVIKRYSYLPLWYTAFYELELTGEPVIR 704
            |||.||:.||||.|||.||||||||||.||..:::::|:..||:.||.:||.|.|..:||.||:|
plant   660 WYQVGAYYPFFRGHAHHDTKRREPWLFGERNTELMRDAIHTRYTLLPYFYTLFREANVTGVPVVR 724

  Fly   705 PLLAQYPLDKEAFGVDNQLLVQDRLLVRPVMQQGVSKVDVYFPAIDDKKNGDWWYDVDTYQRQER 769
            ||..::|.|:..|..|...:|...|||:.|..:|.::..||.|..:.      |||:       |
plant   725 PLWMEFPQDEATFSNDEAFMVGSGLLVQGVYTKGTTQASVYLPGKES------WYDL-------R 776

  Fly   770 SG--YV-----SVPVDDFKIPVWQRGGSIVPKKERQRRASTLMLHDPYTLIICLDRQGKASGSLY 827
            :|  ||     .:...:..||.:|:.|:|:|:|:|.||:|:.|.:|||||::.|:...:|.|.||
plant   777 NGKTYVGGKTHKMDAPEESIPAFQKAGTIIPRKDRFRRSSSQMDNDPYTLVVALNSSQEAEGELY 841

  Fly   828 LDDEKSYAYRQGQRIHVNYEFAHDQLVNSFVGKP--KYKTLAWIERIVIAGLEKVPSSASITVNG 890
            :||.||:.:|:|..||..:.|:...|.::.:..|  :..:...|:||::.|....|.||  .|..
plant   842 IDDGKSFEFRRGSYIHRRFVFSKGVLTSTNLAPPEARLSSQCLIDRIILLGHSSGPKSA--LVEP 904

  Fly   891 VSQQLEV----------LHHDNTVV--VRKPGVKMDVDFAIKL 921
            ::|:.|:          :....|.|  :|||||::|.|:.:|:
plant   905 LNQKAEIEMGPLRMGGLVASSGTKVLTIRKPGVRVDQDWTVKI 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS2alpha	NP_652145.1	GH31_N	224..362	CDD:270212	62/149 (42%)
		Glyco_hydro_31	343..792	CDD:279404	230/456 (50%)
		GH31_GANC_GANAB_alpha	362..833	CDD:269889	240/478 (50%)
RSW3	NP_001330435.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	500	1.000	Domainoid score	I74
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5426
Inparanoid	1	1.050	715	1.000	Inparanoid score	I124
OMA	1	1.010	-	-		QHG54072
OrthoDB	1	1.010	-	-		D100626at2759
OrthoFinder	1	1.000	-	-		FOG0000251
OrthoInspector	1	1.000	-	-		oto3124
orthoMCL	1	0.900	-	-		OOG6_100592
Panther	1	1.100	-	-	LDO	PTHR22762
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1016
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840