DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GCS2alpha and Ganc

DIOPT Version :9

Sequence 1:	NP_652145.1	Gene:	GCS2alpha / 49953	FlyBaseID:	FBgn0027588	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_766260.2	Gene:	Ganc / 76051	MGIID:	1923301	Length:	913	Species:	Mus musculus

Alignment Length:	921	Identity:	393/921 - (42%)
Similarity:	552/921 - (59%)	Gaps:	40/921 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DGVDPGNFKTCEQSSFCRRSRKIQGSGSKYALIPGTLNTYADSLTADLVNKENHHQFAFKLEALV 83
            :.||...||.|.:.:|.||.::.....:.|..:.|:::|..||....::::........::..:.
Mouse    14 EAVDKTIFKDCGKIAFYRRQKQQLTKTTTYQALLGSVDTEQDSTRFQIISEATKIPLVAEVYGIE 78

  Fly    84 GSTFRLQIDEKQPLRPRYRVEHALKGPTQAGRIRVQRETD-GEIVITSEKN--KAVIHGDPFRID 145
            ...|||:|:|:.||:|||.|...:.  ::.|.:|:....| |.:::|:.|.  |..:..:||:||
Mouse    79 KDIFRLKINEETPLKPRYEVPDVIN--SKLGTVRLVCSGDTGSLILTNRKGDLKCHVSANPFKID 141

  Fly   146 FFENDVLVVSVNAKNWLYFEHLRQKAQEPTSHPAENENQQEQDAAVETPKAADTIDDPGAWEENF 210
            ....:..|:|:|:...||||||    |.|....|...|.|...||.    :.:..:|.|.|||.|
Mouse   142 LLSKNEAVISINSLGQLYFEHL----QVPHKQRATKGNGQNTPAAT----SQENQEDLGLWEEKF 198

  Fly   211 KSHHDSKPYGPEAVALDFSFPAAKVLFGIPEHADSFILKSTSGTDPYRLYNLDVFEYVVDSKMAL 275
            ....|.|..||.:|.||||....:.|:|||:||:|..||:|...|.||||||||:.|.|..||.:
Mouse   199 GKFVDVKANGPSSVGLDFSLHGFEHLYGIPQHAESHQLKNTRDGDAYRLYNLDVYGYQVHDKMGI 263

  Fly   276 YGSVPVIYGHGAQRTAGVYWQNAAETWVDIQTSETNVVSSLVNFVSGSQKTPPPA---------A 331
            |||||.:..|...||.|::|.||:||.|:|.| |..|..:|      :|..|..|         .
Mouse   264 YGSVPYLLAHKQGRTVGIFWLNASETLVEINT-EPAVEYTL------TQMGPAAAKQKVRCRTDV 321

  Fly   332 HFMSESGIVDAFIMLGPKPMDTFKQYAALTGTHELPQLFALAYHQSRWNYNDERDVTSVSAKFDE 396
            |:||||||:|.|::.||.|.|.||||:.:|||..:|.||:|.|||.||||.||:||.:|.|.|||
Mouse   322 HWMSESGIIDVFLLTGPTPADVFKQYSYITGTQAMPPLFSLGYHQCRWNYEDEQDVKAVDAGFDE 386

  Fly   397 YNIPMDTMWLDIEHTDGKRYFTWDKFKFPHPLAMIKNLTELGRHLVVIVDPHIKRDNNYFFHRDC 461
            ::||.|.||||||||:.|:||||||.:|.:|..|.:.|....|.||||.|||||.|.:|..:...
Mouse   387 HDIPYDVMWLDIEHTEDKKYFTWDKKRFANPKRMQELLRSKKRKLVVISDPHIKVDPDYTVYAQA 451

  Fly   462 TDRGYYVKTREGNDYEGWCWPGAASYPDFFNPVVREYYASQYALDKFQTVTADVMLWNDMNEPSV 526
            .::|::||..||.|:||.||||.:||.||.||.|||:|:|.:|...:|..|..:.||||||||||
Mouse   452 KEQGFFVKNPEGGDFEGVCWPGLSSYLDFTNPKVREWYSSLFAFPVYQGSTDILFLWNDMNEPSV 516

  Fly   527 FNGPEITAPKDLIHYGNWEHRDVHNLYGHMHLMGSFAGLQQRDP-NQRPFILTRAHFAGSQRYAA 590
            |.|||:|..|..:|||:||||::||:||....|.:..||.||.. .:|||:|:|:.|||||:|.|
Mouse   517 FRGPELTMHKSAVHYGDWEHRELHNIYGFYQQMATAEGLIQRSKGKERPFVLSRSFFAGSQKYGA 581

  Fly   591 IWTGDNFADWSHLQHSVKMCLTEAVAGFSFCGADVGAFFGNPDTELLERWYQTGAFLPFFRAHAH 655
            :|||||.|:||:|:.|:.|.||.:|:|.||||||||.|.|||:.|||.||||.||:.||||.||.
Mouse   582 VWTGDNKAEWSYLKISIPMLLTLSVSGISFCGADVGGFIGNPEAELLVRWYQAGAYQPFFRGHAT 646

  Fly   656 IDTKRREPWLFPERTRQVIQNAVIKRYSYLPLWYTAFYELELTGEPVIRPLLAQYPLDKEAFGVD 720
            ::|||||||||.|...|:|:.|:.:||:.||..|:.||...::.:||:|||..:||.|.|.|.|:
Mouse   647 MNTKRREPWLFGEEYTQLIREAIRQRYALLPYLYSLFYHTHVSSQPVMRPLWVEYPDDLETFAVE 711

  Fly   721 NQLLVQDRLLVRPVMQQGVSKVDVYFPAIDDKKNGDWWYDVDTYQRQERSGYVSVPVDDFKIPVW 785
            ::.::...|||.||.....:.:||:.|..|:.     |||..|:...:....|.:||....|||:
Mouse   712 DEYMLGSALLVHPVTDPQTATIDVFLPGSDEV-----WYDSKTFAYWKGGCTVKIPVTLDTIPVF 771

  Fly   786 QRGGSIVPKKERQRRASTLMLHDPYTLIICLDRQGKASGSLYLDDEKSYAY-RQGQRIHVNYEFA 849
            |||||:||.|.....::..|...||.|.:.|..||.|.|.|||||..|:.| .|.|.::..:.|.
Mouse   772 QRGGSVVPVKTTVGTSTGWMADSPYELRVALSTQGSAVGELYLDDGHSFQYLHQNQFLYRKFLFC 836

  Fly   850 HDQLVNSFVG-KPKYKTLAWIERIVIAGLEKVPSSASITV-NGVSQQLEVLHHDNTVVVR--KPG 910
            ...|.|.... |..|.:...:|:|::.||:|.|||.:..: :|.:|.....:...|..:|  |..
Mouse   837 SSVLTNRCANEKGHYPSKCIVEQILVLGLKKKPSSVTTHLSDGRAQPAAFTYCAETSALRLEKLS 901

  Fly   911 VKMDVDFAIKL 921
            :::..|:.:::
Mouse   902 LRIGEDWEVRV 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS2alpha	NP_652145.1	GH31_N	224..362	CDD:270212	68/146 (47%)
		Glyco_hydro_31	343..792	CDD:279404	233/449 (52%)
		GH31_GANC_GANAB_alpha	362..833	CDD:269889	240/471 (51%)
Ganc	NP_766260.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..188		5/22 (23%)
		GH31_N	212..352	CDD:270212	68/146 (47%)
		Glyco_hydro_31	333..778	CDD:279404	233/449 (52%)
		GH31_GANC_GANAB_alpha	352..819	CDD:269889	240/471 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838271
Domainoid	1	1.000	542	1.000	Domainoid score	I264
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	874	1.000	Inparanoid score	I408
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54072
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000251
OrthoInspector	1	1.000	-	-		otm44348
orthoMCL	1	0.900	-	-		OOG6_100592
Panther	1	1.100	-	-	O	PTHR22762
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1016
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.760