DRSC/TRiP Functional Genomics Resources

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Protein Alignment GCS2alpha and SI

DIOPT Version :9

Sequence 1:NP_652145.1 Gene:GCS2alpha / 49953 FlyBaseID:FBgn0027588 Length:924 Species:Drosophila melanogaster
Sequence 2:NP_001032.2 Gene:SI / 6476 HGNCID:10856 Length:1827 Species:Homo sapiens


Alignment Length:863 Identity:235/863 - (27%)
Similarity:361/863 - (41%) Gaps:158/863 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   147 FENDVLVVSVNAKNWLYFEHLRQKAQEPTSHPAENENQQEQDAAVETPKAADTIDDPGAWEENFK 211
            |.||:..|....:|... ...|.|..:|.:...|..:|..::  ...|..:||:.|....:..|.
Human   139 FGNDINSVLFTTQNQTP-NRFRFKITDPNNRRYEVPHQYVKE--FTGPTVSDTLYDVKVAQNPFS 200

  Fly   212 SHHDSKPYGPEAVALDFSFPAAKVLF----GIPEHADSFILKSTSGTDPYRLYNLDV-----FEY 267
            .....|..|             |.||    |...::|.::..||.....| :|.:..     |.:
Human   201 IQVIRKSNG-------------KTLFDTSIGPLVYSDQYLQISTRLPSDY-IYGIGEQVHKRFRH 251

  Fly   268 VVDSKMALYGSVPV-------------IYGH---------GAQRTAGVYWQNAAETWVDIQTSET 310
            .:..|     :.|:             :|||         .:.::.||:..|:....:.||    
Human   252 DLSWK-----TWPIFTRDQLPGDNNNNLYGHQTFFMCIEDTSGKSFGVFLMNSNAMEIFIQ---- 307

  Fly   311 NVVSSLVNFVSGSQKTPPPAAHFMSESGIVDAFIMLGPKPMDTFKQYAALTGTHELPQLFALAYH 375
                            |.|...:....||:|.:|:||..|....:||..|.|...:|..:.|.:.
Human   308 ----------------PTPIVTYRVTGGILDFYILLGDTPEQVVQQYQQLVGLPAMPAYWNLGFQ 356

  Fly   376 QSRWNYNDERDVTSVSAKFDEYNIPMDTMWLDIEHTDGKRYFTWDKFKFPHPLAMIKNLTELGRH 440
            .|||||.....|..|..:..|..||.||...||::.:.|:.||:|:..|......:::|.:.|:.
Human   357 LSRWNYKSLDVVKEVVRRNREAGIPFDTQVTDIDYMEDKKDFTYDQVAFNGLPQFVQDLHDHGQK 421

  Fly   441 LVVIVDPHI---KRDNNYFFHRDCTDRGYYVKTREGNDYEGW-------------CWPGAASYPD 489
            .|:|:||.|   :|.|.          ..|.....||....|             .|||...|||
Human   422 YVIILDPAISIGRRANG----------TTYATYERGNTQHVWINESDGSTPIIGEVWPGLTVYPD 476

  Fly   490 FFNPVVREYYASQYALDKFQTVTADVMLWNDMNEPSVF-------------NGPEITAP-KDLIH 540
            |.||...:::|::.:: ..|.|..| .||.||||.|.|             |.|..|.. .|.:.
Human   477 FTNPNCIDWWANECSI-FHQEVQYD-GLWIDMNEVSSFIQGSTKGCNVNKLNYPPFTPDILDKLM 539

  Fly   541 YG---------NW-EHRDVHNLYGHMHLMGSFAGLQQRDPNQRPFILTRAHFAGSQRYAAIWTGD 595
            |.         || :..|||:|||:...:.:...:|:..||:|.|||||:.||||.|:||.|.||
Human   540 YSKTICMDAVQNWGKQYDVHSLYGYSMAIATEQAVQKVFPNKRSFILTRSTFAGSGRHAAHWLGD 604

  Fly   596 NFADWSHLQHSVKMCLTEAVAGFSFCGADVGAFFGNPDTELLERWYQTGAFLPFFRAHAHIDTKR 660
            |.|.|..::.|:...|..::.|....|||:..|......||..||.|.|||.||.|.|.....:.
Human   605 NTASWEQMEWSITGMLEFSLFGIPLVGADICGFVAETTEELCRRWMQLGAFYPFSRNHNSDGYEH 669

  Fly   661 REPWLFPERTRQV--IQNAVIKRYSYLPLWYTAFYELELTGEPVIRPLLAQYPLDKEAFGVDNQL 723
            ::|..|.:.:..|  .:..:..||:.||..||.||:..:.||.|.||:|.::..|..::..|.:.
Human   670 QDPAFFGQNSLLVKSSRQYLTIRYTLLPFLYTLFYKAHVFGETVARPVLHEFYEDTNSWIEDTEF 734

  Fly   724 LVQDRLLVRPVMQQGVSKVDVYFP-AIDDKKNGDWWYDVDT-----YQRQERSGYVSVPVDDFKI 782
            |....||:.||::||...|..|.| ||        |||.::     :::|....|  :|.|  ||
Human   735 LWGPALLITPVLKQGADTVSAYIPDAI--------WYDYESGAKRPWRKQRVDMY--LPAD--KI 787

  Fly   783 PVWQRGGSIVPKKERQRRASTLMLHDPYTLIICLDRQGKASGSLYLDD-EKSYAYRQGQRIHVNY 846
            .:..|||.|:|.:|.. ..:|....:|..||:.|.....|.|..:.|| |.....:.|..|...:
Human   788 GLHLRGGYIIPIQEPD-VTTTASRKNPLGLIVALGENNTAKGDFFWDDGETKDTIQNGNYILYTF 851

  Fly   847 EFAHDQL--VNSFVGKPKYKTLAWIERIVIAGLEKVPSSASITVNGVSQQLEVLH-HDNTVVVRK 908
            ..:::.|  |.:.....:..|||: :.:.|.||     :.|:|...|::..:.:: |.|......
Human   852 SVSNNTLDIVCTHSSYQEGTTLAF-QTVKILGL-----TDSVTEVRVAENNQPMNAHSNFTYDAS 910

  Fly   909 PGVKMDVDFAIKL--NFA 924
            ..|.:..|..:.|  ||:
Human   911 NQVLLIADLKLNLGRNFS 928

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GCS2alphaNP_652145.1 GH31_N 224..362 CDD:270212 32/168 (19%)
Glyco_hydro_31 343..792 CDD:279404 160/496 (32%)
GH31_GANC_GANAB_alpha 362..833 CDD:269889 166/519 (32%)
SINP_001032.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 40..61
PD 70..112 CDD:197472
Isomaltase 110..1007 235/863 (27%)
NtCtMGAM_N 125..234 CDD:293468 24/110 (22%)
GH31_N 227..333 CDD:270212 24/131 (18%)
Glyco_hydro_31 324..797 CDD:279404 160/496 (32%)
GH31_MGAM_SI_GAA 343..707 CDD:269888 121/375 (32%)
PD 935..980 CDD:197472
NtCtMGAM_N 994..1107 CDD:293468
Sucrase 1008..1827
GH31_N 1100..1214 CDD:270212
Glyco_hydro_31 1195..1691 CDD:279404
GH31_MGAM_SI_GAA 1214..1601 CDD:269888
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148170
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1501
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000251
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.740

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