Protein Alignment GCS2alpha and MYORG

DIOPT Version :9

• Sequence 1: NP_652145.1
• Gene: GCS2alpha / 49953
• FlyBaseID: FBgn0027588
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_065753.2
• Gene: MYORG / 57462
• HGNCID: 19918
• Length: 714
• Species: Homo sapiens
• Alignment Length: 731
• Identity: 142/731 - (19%)
• Similarity: 234/731 - (32%)
• Gaps: 267/731 - (36%)

  Fly    87 FRLQIDEKQPLRPRYRVEHAL-------------KGPTQAGRIRVQRETDGEIVITSEKNKAVIH 138
            :|::.:|..|.|   .||||:             :..||...||:..:.:.:..:||
Human   159 YRVRWEEAAPGR---AVEHAMFLGDAAAHWYGGAEMRTQHWPIRLDGQQEPQPFVTS-------- 212

  Fly   139 GDPFRIDFFENDVLVVSVNAKNWLYFEHLRQKAQEPTSHPAENENQQEQDAAVETPKAADTIDDP 203
                  |.:.:|.....:..:.||                      ..:.||:   |..|::...
Human   213 ------DVYSSDAAFGGILERYWL----------------------SSRAAAI---KVNDSVPFH 246

  Fly   204 GAWEENFKS------HHDSKPYGP---EAVALDFSFPAAKVLFGIPEHADSFILKSTSGTDPYRL 259
            ..|....:|      :||: ||.|   .|.|.:.|:   :|..|....:....:.......|.|:
Human   247 LGWNSTERSLRLQARYHDT-PYKPPAGRAAAPELSY---RVCVGSDVTSIHKYMVRRYFNKPSRV 307

  Fly   260 YNLDVFEYVVDSKMALYGSVPVIYGHGAQRTAGVYWQNAAETWVDIQTSETNVVSSLVNFVSGSQ 324
            ...:.|...:.|..||||..
Human   308 PAPEAFRDPIWSTWALYGRA--------------------------------------------- 327

  Fly   325 KTPPPAAHFMSESGIVDAFIMLGPKPMDTFKQYAALTGTHELPQLFALAYHQSRWNYNDERDVTS 389
                           ||         .|...::|.....|.
Human   328 ---------------VD---------QDKVLRFAQQIRLHH------------------------ 344

  Fly   390 VSAKFDEYNIPMDTMWLDIEHTDGKRYFTWDKFKFPHPLAMIKNLTELGRHLVVIVDPHIKRDNN 454
                |:..::.:|.|     :|.....|.:|:.|||:...|.:.|.:.|..:.:.|.|.:..:::
Human   345 ----FNSSHLEIDDM-----YTPAYGDFDFDEVKFPNASDMFRRLRDAGFRVTLWVHPFVNYNSS 400

  Fly   455 YFFHRDCTDRGYYVKTREGN--DYEGWCWPGAASYPDFFNPVVREYY-------ASQYALDKFQT 510
            .|  .:..:|..:|:...|.  ....| |.|..:..||.:|..|:::       .|:|::..|:
Human   401 RF--GEGVERELFVREPTGRLPALVRW-WNGIGAVLDFTHPKARDWFQGHLRRLRSRYSVASFK- 461

  Fly   511 VTADVMLWNDMNEPSVFNGPEIT-APKDLIHY------GNWEHRDVHNLYGHMHLMGSFAGLQQR 568
                            |:..|:: .|:|...|      ..|..|     |..|.|
Human   462 ----------------FDAGEVSYLPRDFSTYRPLPDPSVWSRR-----YTEMAL---------- 495

  Fly   569 DPNQRPFILTRAHFAG--SQRYAAIW-TGDNFADWSH---LQHSVKMCLTEAVAGFSF------- 620
                 ||........|  ||..:..: ..|..:.|.:   |:..:...||.::.|:.|
Human   496 -----PFFSLAEVRVGYQSQNISCFFRLVDRDSVWGYDLGLRSLIPAVLTVSMLGYPFILPDMVG 555

  Fly   621 --------CGADVGAFFGNPDTELLERWYQTGAFLPFFRAHAHIDTKRREPWLFPERTRQVIQNA 677
                    .|.||      |:.||..||.:..||:|..:...       .||.:......:.|..
Human   556 GNAVPQRTAGGDV------PERELYIRWLEVAAFMPAMQFSI-------PPWRYDAEVVAIAQKF 607

  Fly   678 VIKRYSYL-PLWYTAFYELELTGEPVIRPLLAQYPLDKEAFGVDNQLLVQDRLLVRPVMQQGVSK 741
            ...|.|.: ||......|:..||:|::|||....|.|:.|..:|:|.|:.|.|||.||::.|..:
Human   608 AALRASLVAPLLLELAGEVTDTGDPIVRPLWWIAPGDETAHRIDSQFLIGDTLLVAPVLEPGKQE 672

  Fly   742 VDVYFPAIDDKKNGDW 757
            .|||.||      |.|
Human   673 RDVYLPA------GKW 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCS2alpha	NP_652145.1	GH31_N	224..362	CDD:270212	16/137 (12%)
		Glyco_hydro_31	343..792	CDD:279404	98/453 (22%)
		GH31_GANC_GANAB_alpha	362..833	CDD:269889	96/434 (22%)
MYORG	NP_065753.2	GH31_NET37	314..682	CDD:269878	104/528 (20%)
		Glyco_hydro_31	329..707	CDD:279404	99/455 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148176
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740