DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GCS2alpha and GANC

DIOPT Version :9

Sequence 1:	NP_652145.1	Gene:	GCS2alpha / 49953	FlyBaseID:	FBgn0027588	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001380857.1	Gene:	GANC / 2595	HGNCID:	4139	Length:	914	Species:	Homo sapiens

Alignment Length:	919	Identity:	390/919 - (42%)
Similarity:	557/919 - (60%)	Gaps:	35/919 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DGVDPGNFKTCEQSSFCRRSRKIQGSGSKYALIPGTLNTYADSLTADLVNKENHHQFAFKLEALV 83
            :.||...|:.|.:.:|.||.::.....|.|..:..::.|..||....::|:.:......::..:.
Human    14 EAVDKNIFRDCNKIAFYRRQKQWLSKKSTYQALLDSVTTDEDSTRFQIINEASKVPLLAEIYGIE 78

  Fly    84 GSTFRLQIDEKQPLRPRYRVEHALKG-PTQAGRIRVQRETDGEIVITSEKN--KAVIHGDPFRID 145
            |:.|||:|:|:.||:||:.|...|.. |:....|....:| |.:::...|.  |..|..:||::|
Human    79 GNIFRLKINEETPLKPRFEVPDVLTSKPSTVRLISCSGDT-GSLILADGKGDLKCHITANPFKVD 142

  Fly   146 FFENDVLVVSVNAKNWLYFEHL----RQKAQEPTSHPAENENQQEQDAAVETPKAADTIDDPGAW 206
            ....:.:|:|:|:...||||||    :|:|.:      |||.:...|.:.|..      :|.|.|
Human   143 LVSEEEVVISINSLGQLYFEHLQILHKQRAAK------ENEEETSVDTSQENQ------EDLGLW 195

  Fly   207 EENFKSHHDSKPYGPEAVALDFSFPAAKVLFGIPEHADSFILKSTSGTDPYRLYNLDVFEYVVDS 271
            ||.|....|.|..||.::.||||....:.|:|||:||:|..||:|...|.||||||||:.|.:..
Human   196 EEKFGKFVDIKANGPSSIGLDFSLHGFEHLYGIPQHAESHQLKNTGDGDAYRLYNLDVYGYQIYD 260

  Fly   272 KMALYGSVPVIYGHGAQRTAGVYWQNAAETWVDIQTSETNVVSSLVNF--VSGSQKTPPPA-AHF 333
            ||.:|||||.:..|...||.|::|.||:||.|:|.| |..|..:|...  |:..||..... .|:
Human   261 KMGIYGSVPYLLAHKLGRTIGIFWLNASETLVEINT-EPAVEYTLTQMGPVAAKQKVRSRTHVHW 324

  Fly   334 MSESGIVDAFIMLGPKPMDTFKQYAALTGTHELPQLFALAYHQSRWNYNDERDVTSVSAKFDEYN 398
            ||||||:|.|::.||.|.|.||||:.||||..:|.||:|.|||.||||.||:||.:|.|.|||::
Human   325 MSESGIIDVFLLTGPTPSDVFKQYSHLTGTQAMPPLFSLGYHQCRWNYEDEQDVKAVDAGFDEHD 389

  Fly   399 IPMDTMWLDIEHTDGKRYFTWDKFKFPHPLAMIKNLTELGRHLVVIVDPHIKRDNNYFFHRDCTD 463
            ||.|.||||||||:|||||||||.:||:|..|.:.|....|.||||.|||||.|.:|..:....|
Human   390 IPYDAMWLDIEHTEGKRYFTWDKNRFPNPKRMQELLRSKKRKLVVISDPHIKIDPDYSVYVKAKD 454

  Fly   464 RGYYVKTREGNDYEGWCWPGAASYPDFFNPVVREYYASQYALDKFQTVTADVMLWNDMNEPSVFN 528
            :|::||.:||.|:||.||||.:||.||.||.|||:|:|.:|...:|..|..:.|||||||||||.
Human   455 QGFFVKNQEGEDFEGVCWPGLSSYLDFTNPKVREWYSSLFAFPVYQGSTDILFLWNDMNEPSVFR 519

  Fly   529 GPEITAPKDLIHYGNWEHRDVHNLYGHMHLMGSFAGLQQRDP-NQRPFILTRAHFAGSQRYAAIW 592
            |||.|..|:.||:||||||::||:||..|.|.:..||.:|.. .:|||:|||:.|||||:|.|:|
Human   520 GPEQTMQKNAIHHGNWEHRELHNIYGFYHQMATAEGLIKRSKGKERPFVLTRSFFAGSQKYGAVW 584

  Fly   593 TGDNFADWSHLQHSVKMCLTEAVAGFSFCGADVGAFFGNPDTELLERWYQTGAFLPFFRAHAHID 657
            ||||.|:||:|:.|:.|.||.::.|.||||||:|.|.|||:||||.||||.||:.||||.||.::
Human   585 TGDNTAEWSNLKISIPMLLTLSITGISFCGADIGGFIGNPETELLVRWYQAGAYQPFFRGHATMN 649

  Fly   658 TKRREPWLFPERTRQVIQNAVIKRYSYLPLWYTAFYELELTGEPVIRPLLAQYPLDKEAFGVDNQ 722
            |||||||||.|...::|:.|:.:||..||.||:.||...:..:||:|||..::|.:.:.|.::::
Human   650 TKRREPWLFGEEHTRLIREAIRERYGLLPYWYSLFYHAHVASQPVMRPLWVEFPDELKTFDMEDE 714

  Fly   723 LLVQDRLLVRPVMQQGVSKVDVYFPAIDDKKNGDWWYDVDTYQRQERSGYVSVPVDDFKIPVWQR 787
            .::...|||.||.:...:.|||:.|.     :.:.|||..|:...|....|.:||....|||:||
Human   715 YMLGSALLVHPVTEPKATTVDVFLPG-----SNEVWYDYKTFAHWEGGCTVKIPVALDTIPVFQR 774

  Fly   788 GGSIVPKKERQRRASTLMLHDPYTLIICLDRQGKASGSLYLDDEKSYAY-RQGQRIHVNYEFAHD 851
            |||::|.|....:::..|....|.|.:.|..:|.:.|.|||||..|:.| .|.|.:|..:.|...
Human   775 GGSVIPIKTTVGKSTGWMTESSYGLRVALSTKGSSVGELYLDDGHSFQYLHQKQFLHRKFSFCSS 839

  Fly   852 QLVNSFVG-KPKYKTLAWIERIVIAGLEKVPSSASI-TVNGVSQQLEVLHHDNTVV--VRKPGVK 912
            .|:|||.. :..|.:...:|:|::.|..|.|||.:. :.:|..|.:...:...|.:  :.|..:.
Human   840 VLINSFADQRGHYPSKCVVEKILVLGFRKEPSSVTTHSSDGKDQPVAFTYCAKTSILSLEKLSLN 904

  Fly   913 MDVDFAIKL 921
            :..|:.:::
Human   905 IATDWEVRI 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS2alpha	NP_652145.1	GH31_N	224..362	CDD:270212	67/140 (48%)
		Glyco_hydro_31	343..792	CDD:279404	236/449 (53%)
		GH31_GANC_GANAB_alpha	362..833	CDD:269889	238/471 (51%)
GANC	NP_001380857.1	GH31_N	213..353	CDD:270212	67/140 (48%)
GANC	NP_001380857.1	GH31_GANC_GANAB_alpha	353..820	CDD:269889	238/471 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148178
Domainoid	1	1.000	543	1.000	Domainoid score	I262
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	874	1.000	Inparanoid score	I415
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54072
OrthoDB	1	1.010	-	-		D100626at2759
OrthoFinder	1	1.000	-	-		FOG0000251
OrthoInspector	1	1.000	-	-		otm42296
orthoMCL	1	0.900	-	-		OOG6_100592
Panther	1	1.100	-	-	O	PTHR22762
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1016
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.770