DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GCS2alpha and Mgam

DIOPT Version :9

Sequence 1:	NP_652145.1	Gene:	GCS2alpha / 49953	FlyBaseID:	FBgn0027588	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001355804.1	Gene:	Mgam / 232714	MGIID:	1203495	Length:	3616	Species:	Mus musculus

Alignment Length:	814	Identity:	229/814 - (28%)
Similarity:	348/814 - (42%)	Gaps:	134/814 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 DGEIVITSEKNKAVIHGDPFRIDF---FENDVLVVSVNAKNWLYF---EHLRQKAQEPTSH--PA 179
            :.::|.|:....|.:...|....|   .||.:|.......|..:|   :..:::.:.|..|  |.
Mouse   115 ESDVVNTNAGFTATLKNLPSAPVFGNSIENILLTAEYQTSNRFHFKLTDQTKKRYEVPHEHVQPF 179

  Fly   180 ENENQQEQDAAVETPKAADTIDDPGAWEENFKSHH----DSKPYGPEAVA---LDFS--FPAAKV 235
            ........:..||..|      :|.:.:...||::    ||. .||...:   |.||  .|:|.|
Mouse   180 SGNAPSSLNYKVEVSK------EPFSIKVTRKSNNRVLFDSS-IGPLLFSDQFLQFSTHLPSANV 237

  Fly   236 LFGIPEHADS-------------FILKSTSGTDPYRLYNLDVFEYVVDSKMALYGSVPVIYGHGA 287
             :|:.||...             |...:|...|...||.:..|...::....|
Mouse   238 -YGLGEHVHQQYRHNMNWKTWPMFSRDTTPNEDGTNLYGVQTFFLCLEDNSGL------------ 289

  Fly   288 QRTAGVYWQNAAETWVDIQTSETNVVSSLVNFVSGSQKTPPPAAHFMSESGIVDAFIMLGPKPMD 352
              :.||:..|:....|.:|                    |.||..:.:..||:|.::.||..|..
Mouse   290 --SFGVFLMNSNAMEVTLQ--------------------PTPAITYRTTGGILDFYVFLGNTPEQ 332

  Fly   353 TFKQYAALTGTHELPQLFALAYHQSRWNYNDERDVTSVSAKFDEYNIPMDTMWLDIEHTDGKRYF 417
            ..::|..|.|...||..:.|.:..||::|....::.:|..:.....:|.|....||::.|.|:.|
Mouse   333 VVQEYLELIGRPALPSYWTLGFQLSRYDYKSLDNMKAVVERNRAAQLPYDVQHADIDYMDQKKDF 397

  Fly   418 TWDKFKFPHPLAMIKNLTELGRHLVVIVDPHIKRDNNYFFHRDC--TDRG----YYVKTREG-ND 475
            |:|...|......:|.|...|:.||:|:||.|  .||.|.....  .|||    .:|.:.:| :.
Mouse   398 TYDPVNFKGFPEFVKELHNNGQKLVIILDPAI--SNNSFSSNPYGPYDRGSAMKIWVNSSDGISP 460

  Fly   476 YEGWCWPGAASYPDFFNPVVREYYASQYALDKFQTVTADVMLWNDMNEPSVF------------- 527
            ..|..|||...:||:.:|....::..::.|  |........:|.||||.|.|
Mouse   461 VIGKVWPGTTVFPDYTSPNCAVWWTKEFEL--FHKEVEFDGIWIDMNEVSNFIDGSFSGCSQNNL 523

  Fly   528 NGPEITAPKDLIHY-----------GNW-EHRDVHNLYGHMHLMGSFAGLQQRDPNQRPFILTRA 580
            |.|..| ||.|..|           .:| :..|||||||:...:.:...::...|::|.||:||:
Mouse   524 NYPPFT-PKVLDGYLFSKTLCMDAVQHWGKQYDVHNLYGYSMAIATAKAVKDVFPDKRSFIITRS 587

  Fly   581 HFAGSQRYAAIWTGDNFADWSHLQHSVKMCLTEAVAGFSFCGADVGAFFGNPDTELLERWYQTGA 645
            .||||.::||.|.|||.|.|..||.|:...|...:.|....|||:..|..:...||..||.|.||
Mouse   588 TFAGSGKFAAHWLGDNTATWKDLQWSIPGMLEFNLFGIPMVGADICGFAQDTYEELCRRWMQLGA 652

  Fly   646 FLPFFRAHAHIDTKRREPWLFPERTRQVIQNA----VIKRYSYLPLWYTAFYELELTGEPVIRPL 706
            |.||.|.|.....|.::|..|...:  ::.|:    :..||:.||..||.||.....|:.|.|||
Mouse   653 FYPFSRNHNGQGYKDQDPASFGNNS--LLLNSSRHYLNIRYTLLPYLYTLFYRAHSRGDTVARPL 715

  Fly   707 LAQYPLDKEAFGVDNQLLVQDRLLVRPVMQQGVSKVDVYFPAIDDKKNGDWWYDVDTYQR---QE 768
            |.::..|...:|:|.|.|....||:.||:.||..||..|.|       ...|||.:|.:.   ::
Mouse   716 LHEFYDDNNTWGIDRQFLWGPGLLITPVLDQGAEKVKAYVP-------NATWYDYETGEELGWRK 773

  Fly   769 RSGYVSVPVDDFKIPVWQRGGSIVPKKERQRRAST--LMLHDPYTLIICLDRQGKASGSLYLDDE 831
            :|..:.:|.|  ||.:..|||.|.|   .|:.|:|  ....:|..||:.||...:|.|.|:.||.
Mouse   774 QSIEMQLPGD--KIGLHLRGGYIFP---TQQPATTTEASRKNPLGLIVALDENKEARGELFWDDG 833

  Fly   832 KSYAYRQGQRIHVNYEFAHDQ-LVNSFVGKPKYK 864
            :| .....|.|::..||:..| .::..:..|.||
Mouse   834 ES-KDTVAQNIYLFSEFSVTQNHLDVTISSPNYK 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS2alpha	NP_652145.1	GH31_N	224..362	CDD:270212	32/155 (21%)
		Glyco_hydro_31	343..792	CDD:279404	155/487 (32%)
		GH31_GANC_GANAB_alpha	362..833	CDD:269889	165/511 (32%)
Mgam	NP_001355804.1	Trefoil	65..107	CDD:365865
		NtCtMGAM_N	124..233	CDD:374852	24/115 (21%)
		GH31_N	226..342	CDD:270212	32/150 (21%)
		GH31_MGAM_SI_GAA	342..705	CDD:269888	117/369 (32%)
		PD	934..972	CDD:197472
		NtCtMGAM_N	988..1101	CDD:374852
		GH31_N	1087..1208	CDD:270212
		Glyco_hydro_31	1189..1690	CDD:376446
		Trefoil	1828..1867	CDD:238059
		NtCtMGAM_N	1883..1996	CDD:374852
		GH31_N	1982..2103	CDD:270212
		GH31_MGAM_SI_GAA	2103..2496	CDD:269888
		PD	2720..2764	CDD:197472
		NtCtMGAM_N	2777..2890	CDD:374852
		GH31_N	2876..2997	CDD:270212
		Glyco_hydro_31	2978..3480	CDD:376446
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838273
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000251
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740