DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCS2alpha and aagr-4

DIOPT Version :9

Sequence 1:	NP_652145.1	Gene:	GCS2alpha / 49953	FlyBaseID:	FBgn0027588	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_508105.2	Gene:	aagr-4 / 180400	WormBaseID:	WBGene00018682	Length:	903	Species:	Caenorhabditis elegans

Alignment Length:	933	Identity:	407/933 - (43%)
Similarity:	574/933 - (61%)	Gaps:	52/933 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VAIIWALFVLADGVDPGNFKTCEQSSFCRRSRKIQGSGSKYALIPGTLNTYADSLTADLVNKENH 72
            :.:.|.|....|.||..||||||||.||:|.|.:. |.:.|.::..::.|....|.|.:.||:.
Worm     4 LVVAWLLIGALDAVDRQNFKTCEQSGFCKRHRAVT-SPTGYEVVGDSVKTNETGLHALIKNKDT- 66

  Fly    73 HQFAFKLEALVGSTFRLQIDEKQ-PLRPRYRVEHAL--KGPTQAGRIRVQRETDGEIVITSEKNK 134
             .....:.||..||.|:.|||.. .||.||:...||  :.|.|....:::.|.....|:|::.|:
Worm    67 -TLRLSIVALKDSTVRVVIDENDGALRKRYQPLEALVDREPAQQKVKKIKEEATATKVLTTDGNR 130

  Fly   135 AVIHGDPFRIDFFENDVLVVSVNAKNWLYFEHLRQKAQEPTSHPAENENQQEQDAAVETPKAADT 199
            .|:...||||||:..|.:|.|:|||..|:||..::|.                       ..:|.
Worm   131 IVLQHKPFRIDFYVKDKIVSSINAKETLHFEAFKKKV-----------------------LLSDR 172

  Fly   200 IDDPGAWEENFKSHHDSKPYGPEAVALDFSFPAAKVLFGIPEHADSFILKSTSGTDPYRLYNLDV 264
              :.|.|||.||...|:||:|..:|.:|.:|..||.:|||||||:|:.|:.|...:|||||||||
Worm   173 --EKGFWEETFKEIKDTKPHGSSSVGVDIAFVGAKHVFGIPEHAESYSLRDTRTYEPYRLYNLDV 235

  Fly   265 FEYVVDSKMALYGSVPVIYGHGAQRTAGVYWQNAAETWVDIQ--TSETNVVS-SLVNFVSGSQKT 326
            |||..:|.||||||:|.:.|...:|:.|..|.|||||||||:  |::...:| .:::..:..::.
Worm   236 FEYETNSPMALYGSIPYLVGVHQKRSVGALWLNAAETWVDIEPTTADKGGLSKEVLDADTKPRQV 300

  Fly   327 PPPAAHFMSESGIVDAFIMLGPKPMDTFKQYAALTGTHELPQLFALAYHQSRWNYNDERDVTSVS 391
            |...|.|.||||::|.||.|||:|.|.|:|.|||||...||..|||.||||||||.|::||..|.
Worm   301 PQHNARFYSESGLIDVFITLGPQPNDIFRQLAALTGVTPLPPAFALGYHQSRWNYKDQKDVKEVH 365

  Fly   392 AKFDEYNIPMDTMWLDIEHTDGKRYFTWDKFKFPHPLAMIKNLTELGRHLVVIVDPHIKRDNNYF 456
            ..|.:::||:|.:||||||||.|.|||:||..|..|..|||:|.:..|.||.|||||||:|:.|:
Worm   366 DGFVKHDIPLDVLWLDIEHTDNKAYFTFDKDAFGKPEDMIKDLADKNRKLVTIVDPHIKKDSKYY 430

  Fly   457 FHRDCTDRGYYVKTREGNDYEGWCWPGAASYPDFFNPVVREYYASQYALDKFQTVTADVMLWNDM 521
            .:::.....|.||..:...|||.||||.::|.||.||..|::::.|:|.||::..|.||.:||||
Worm   431 IYKEAKKNKYLVKDAKDTIYEGNCWPGDSTYIDFINPKARKWWSEQFAFDKYKGTTKDVHIWNDM 495

  Fly   522 NEPSVFNGPEITAPKDLIHYGNWEHRDVHNLYG-HMHLMGSFAGLQQRDPNQ-RPFILTRAHFAG 584
            ||||||||||||..||..|:|.:|||||||:|| |.| ..:|.||:.|..|: |||:|:|:.|||
Worm   496 NEPSVFNGPEITMHKDAKHHGEFEHRDVHNVYGFHQH-SSTFEGLKARSNNEVRPFVLSRSFFAG 559

  Fly   585 SQRYAAIWTGDNFADWSHLQHSVKMCLTEAVAGFSFCGADVGAFFGNPDTELLERWYQTGAFLPF 649
            |||.||:|||||.|||:||:.|:.|.|:.:.||..|.|||||.||||||.|||.||||.|||.||
Worm   560 SQRTAAVWTGDNKADWAHLKQSIPMLLSLSTAGLPFVGADVGGFFGNPDEELLVRWYQAGAFQPF 624

  Fly   650 FRAHAHIDTKRREPWLFPERTRQVIQNAVIKRYSYLPLWYTAFYELELTGEPVIRPLLAQYPLDK 714
            ||.|:|.||||||||||.:.|.:.|:||:..||::||.|||.|||...||:||:||...::..|:
Worm   625 FRGHSHQDTKRREPWLFADNTTEAIRNAIKTRYAFLPYWYTLFYEHAKTGKPVMRPFWMEFIEDE 689

  Fly   715 EAFGVDNQLLVQDRLLVRPVMQQGVSKVDVYFPAIDDKKNGDWWYDVDTYQRQERSGYVSVPVDD 779
            .::..|.|.:|.:.|||:||:::.|.::.:|.|.     ....|||.:|::.:...|.|.:|.:.
Worm   690 PSWDEDRQWMVGNGLLVKPVLEEKVKELSIYLPG-----KRQVWYDWETHKARPSPGAVQIPAEL 749

  Fly   780 FKIPVWQRGGSIVPKKERQRRASTLMLHDPYTLIICLDRQGK-ASGSLYLDDEKSYAYRQGQRIH 843
            ..|.::.|||:|:||....:..:......|..|.|.::::|. |:|::||||.:||||.:|...:
Worm   750 NTIGLYHRGGTIIPKLSEVKLTTKENHEQPIILYIAVNQKGDFANGTIYLDDGESYAYEKGDFAY 814

  Fly   844 VNYEF--AHDQL---VNSFVGKP-KYKTLAWIERIVIAGLEKVPSSASITVNGVS-QQLEV-LHH 900
            ..:.|  .||.|   .|..:.|. |:.:..:|::|||.|.:..|.:|.|.::..| :.||. .:.
Worm   815 WGFTFKREHDYLHTITNKNLDKKGKFDSDVYIDKIVIRGAKFYPRNAHIFLDDFSPEDLEFEFNR 879

  Fly   901 DNTVV-VRKPGVKMDVDFAIKLN 922
            ||.:: :..||..:..:|.|.::
Worm   880 DNFLMEIANPGAFVTREFRIDIH 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS2alpha	NP_652145.1	GH31_N	224..362	CDD:270212	70/140 (50%)
		Glyco_hydro_31	343..792	CDD:279404	235/450 (52%)
		GH31_GANC_GANAB_alpha	362..833	CDD:269889	235/473 (50%)
aagr-4	NP_508105.2	DUF4968	61..146	CDD:379828	29/86 (34%)
		GH31_N	197..336	CDD:270212	69/138 (50%)
		GH31_GANC_GANAB_alpha	336..804	CDD:269889	235/473 (50%)
		DUF5110	779..852	CDD:379926	25/72 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159048
Domainoid	1	1.000	499	1.000	Domainoid score	I175
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5426
Inparanoid	1	1.050	751	1.000	Inparanoid score	I291
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54072
OrthoDB	1	1.010	-	-		D100626at2759
OrthoFinder	1	1.000	-	-		FOG0000251
OrthoInspector	1	1.000	-	-		otm14579
orthoMCL	1	0.900	-	-		OOG6_100592
Panther	1	1.100	-	-	O	PTHR22762
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R499
SonicParanoid	1	1.000	-	-		X1016
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.840