DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCS2alpha and aagr-3

DIOPT Version :9

Sequence 1:	NP_652145.1	Gene:	GCS2alpha / 49953	FlyBaseID:	FBgn0027588	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_505507.1	Gene:	aagr-3 / 179364	WormBaseID:	WBGene00009583	Length:	924	Species:	Caenorhabditis elegans

Alignment Length:	928	Identity:	394/928 - (42%)
Similarity:	558/928 - (60%)	Gaps:	59/928 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 NFKTCEQSSFCRRSRKI---QGSGSK----------YALIPGTLNTYADSLTADLVNKENHHQFA 76
            :|||||||:||::.|.|   :||.:.          |.|:..::..:....||::.|.:|  ...
Worm    27 DFKTCEQSAFCKQHRAITVRRGSQNHHNWSLQEPTGYELLADSITHHGAVWTANVRNSQN--TLK 89

  Fly    77 FKLEALVGSTFRLQIDE-KQPLRPRYRVEHALKG-PTQAGRIRVQR-ETDGEIVITSEKNKAVIH 138
            ..:..|..||.|:|||| :..:|.||....||.. |.:.....|:. :.:.:|:..::|.|.|:.
Worm    90 INVIGLADSTVRVQIDEPESAIRKRYVPNPALVSLPEELEFSSVENGDQEAKIIGGNKKLKVVVT 154

  Fly   139 GDPFRIDFF-ENDVLVVSVNAKNWLYFEHLRQKAQEPTSHPAENENQQEQDAAVETPKAADTIDD 202
            ..||.:..| |.|.||..:|....|..|..|.| :|...:|
Worm   155 YKPFLVSIFNEFDELVAQLNRDGKLKVEEFRTK-EEGKEYP------------------------ 194

  Fly   203 PGAWEENFKSHHDSKPYGPEAVALDFSFPAAKVLFGIPEHADSFILKSTSG-TDPYRLYNLDVFE 266
            .|.|||.||...|.|.:|..:|.:|.||...|..:|:|||||:|.|::|.| :||||||||||||
Worm   195 EGFWEERFKGFTDHKQHGSSSVGVDISFVNFKTAYGLPEHADAFALRNTVGNSDPYRLYNLDVFE 259

  Fly   267 YVVDSKMALYGSVPVIYGHGAQRTAGVYWQNAAETWVDIQTSETN--VVSSLVNFVSGSQKTPPP 329
            |.:::.||||.|:|.|..|.|.|:.|..|.||||||||.|:|.|:  :...:::.|:||....|.
Worm   260 YELNNPMALYVSIPYILAHRANRSVGALWFNAAETWVDTQSSVTSKGLFGKMLDKVTGSSDNVPH 324

  Fly   330 -AAHFMSESGIVDAFIMLGPKPMDTFKQYAALTGTHELPQLFALAYHQSRWNYNDERDVTSVSAK 393
             .|||:||||:||.|..:||...|..:|.:.|||...||.||::.|||.|||||||:||.:|:..
Worm   325 FDAHFISESGLVDVFFFVGPTVKDVQRQNSKLTGVTPLPPLFSIGYHQCRWNYNDEQDVATVNQG 389

  Fly   394 FDEYNIPMDTMWLDIEHTDGKRYFTWDKFKFPHPLAMIKNLTELGRHLVVIVDPHIKRDNNYFFH 458
            ||::::|||.:||||||||||:||||||.|||.|..|:..:...||.:|.|||||||:|:.|:.:
Worm   390 FDDHDMPMDVIWLDIEHTDGKKYFTWDKHKFPTPNDMVDKVAAKGRKMVTIVDPHIKKDDGYYVY 454

  Fly   459 RDCTDRGYYVKTREGNDYEGWCWPGAASYPDFFNPVVREYYASQYALDKFQTVTADVMLWNDMNE 523
            :|..|:|.:||..:|:|:||.||||::.|.||::|..|.|:..|:|.|::...::::.:||||||
Worm   455 KDAKDKGLFVKRVDGSDFEGHCWPGSSEYLDFWHPDTRSYWKDQFAFDRYTGSSSNLHIWNDMNE 519

  Fly   524 PSVFNGPEITAPKDLIHYGNWEHRDVHNLYGHMHLMGSFAGLQQR-DPNQRPFILTRAHFAGSQR 587
            ||||:|||||..|:.||||..|||::||:||.|:...:|.|:..| ...:|||:|:||.|.|:||
Worm   520 PSVFSGPEITMDKESIHYGGIEHREIHNMYGMMYTSATFDGMIARTGGKERPFLLSRAGFIGTQR 584

  Fly   588 YAAIWTGDNFADWSHLQHSVKMCLTEAVAGFSFCGADVGAFFGNPDTELLERWYQTGAFLPFFRA 652
            .||||||||.|||.||:.:..|.|:.::||..|.|||||.||||||.:||.|||||.||.|||||
Worm   585 TAAIWTGDNTADWGHLEIAAPMTLSLSIAGVPFVGADVGGFFGNPDEQLLSRWYQTAAFQPFFRA 649

  Fly   653 HAHIDTKRREPWLFPERTRQVIQNAVIKRYSYLPLWYTAFYELELTGEPVIRPLLAQYPLDKEAF 717
            ||||||:|||||||.|:|:|:|:.|:..||:.||.|||.|.:....|.|.:|||..::..|....
Worm   650 HAHIDTRRREPWLFSEQTQQIIREALRTRYALLPYWYTLFQQHTENGVPPMRPLFYEFENDDLLL 714

  Fly   718 GVDNQLLVQDRLLVRPVMQQGVSKVDVYFPAIDDKKNGDWWYDVDTYQRQERSGYVSVPVDDFKI 782
            ....|.:|...:|.|||:::....|.|..|. .:.|...|:..|...:.:..|.||..|:.  ..
Worm   715 EEQKQWMVGSGILARPVVEKDTFNVQVKLPR-GEHKTERWFEWVSGNEVRGESIYVDAPIT--FT 776

  Fly   783 PVWQRGGSIVPKKERQRRASTLMLHDPYTLIICLDRQGKASGSLYLDDEKSYAYRQGQRIHVNYE 847
            |::||||:|:|..:|.||::|||..||.||.:.||....::|.:||||..::.|:.||.:..:::
Worm   777 PIYQRGGTIIPTWQRIRRSATLMKDDPITLFVALDSNENSNGEIYLDDGNTHDYQSGQFVKASFK 841

  Fly   848 FA----HDQLVNSFVGKPKYKTLAWIERIVIAGLEKVPSSASIT-VNGVSQQLEVLH-HDNTV-V 905
            :.    :..::.......||....||||:|:.|:|..|....|| |:...|.||..: ||:.| |
Worm   842 YTTLSKNSAMLEGEHLDGKYAAKNWIERVVVRGVESSPKKVEITRVSDPVQSLEFSYDHDSKVLV 906

  Fly   906 VRKPGVKMDVDFAIKLNF 923
            :|||...:...|.:.:.|
Worm   907 IRKPEALLTSSFKVHIEF 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS2alpha	NP_652145.1	GH31_N	224..362	CDD:270212	70/141 (50%)
		Glyco_hydro_31	343..792	CDD:279404	222/449 (49%)
		GH31_GANC_GANAB_alpha	362..833	CDD:269889	234/471 (50%)
aagr-3	NP_505507.1	GH31_N	229..358	CDD:270212	65/128 (51%)
		GH31_GANC_GANAB_alpha	358..827	CDD:269889	234/471 (50%)
		DUF5110	803..875	CDD:379926	20/71 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	499	1.000	Domainoid score	I175
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5426
Inparanoid	1	1.050	751	1.000	Inparanoid score	I291
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54072
OrthoDB	1	1.010	-	-		D100626at2759
OrthoFinder	1	1.000	-	-		FOG0000251
OrthoInspector	1	1.000	-	-		otm14579
orthoMCL	1	0.900	-	-		OOG6_100592
Panther	1	1.100	-	-	LDO	PTHR22762
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R499
SonicParanoid	1	1.000	-	-		X1016
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.010