DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCS2alpha and aagr-2

DIOPT Version :9

Sequence 1:	NP_652145.1	Gene:	GCS2alpha / 49953	FlyBaseID:	FBgn0027588	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_494897.3	Gene:	aagr-2 / 173848	WormBaseID:	WBGene00019895	Length:	955	Species:	Caenorhabditis elegans

Alignment Length:	992	Identity:	233/992 - (23%)
Similarity:	351/992 - (35%)	Gaps:	275/992 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 WALFVLADGVDPGNFKTCEQSSFCRRSRKIQGSGSKYALIPGTLNTYADSLTADLVNKENHHQFA 76
            |..|  .|||   .:....|.......||..|..:.:.         |||....|..|.
Worm    53 WCYF--KDGV---GYNLDSQQGSTYNLRKNGGPSNPWG---------ADSTEIKLTTKS------ 97

  Fly    77 FKLEALVGSTFRLQIDEKQPLRPRYRVEHALKGPTQAGRIRVQRETDGEIVITSEKNKAVIHGDP 141
                  :||...::|.          ::...:.|....| ..|..|:...:.||..|
Worm    98 ------IGSVLNVKIG----------IDGRYEPPVDFPR-ETQSSTESLSLSTSFSN-------- 137

  Fly   142 FRIDFFENDVLVVSVNAK------NWLYFEHLRQKAQEPTSHPAENENQQEQDAAVETPKAADTI 200
               ..|...|:..|.|.|      ..|.|..  |..|..|..|:||..
Worm   138 ---GVFSFSVVRQSTNRKLFDTSIGGLIFSD--QFIQIATYLPSENMY----------------- 180

  Fly   201 DDPGAWEENFKSHHDSKPYGPEAVALDFSFPAAKVLFG--IPEHADSFILKSTSGTDPYRLYNLD 263
                .|.||  :|        :::..||:......:|.  .|.::.|....:..|..||
Worm   181 ----GWGEN--TH--------QSLRHDFTKYLTWAMFARDQPPNSGSLDTVNLYGVHPY------ 225

  Fly   264 VFEYVV---DSKMALYGSVPVIYGHGAQRTAGVYWQNAAETWVDIQTSETNVVSSLVNFVSGSQK 325
               |::   |.|           .||                |.|..|....|::
Worm   226 ---YMILEPDGK-----------AHG----------------VLIINSNAQEVTT---------- 250

  Fly   326 TPPPAAHFMSESGIVDAFIMLGPKPMDTFKQYAALTGTHELPQLFALAYHQSRWNYNDERDV-TS 389
            .|.|:..:.:..|.:|.:...||.|....:||....|...||..:||.|..||:.|....:: |.
Worm   251 APGPSLIYRTIGGNLDMYFFPGPTPEMVTQQYLKFIGKPFLPAYWALGYQLSRYGYKGLAEMKTR 315

  Fly   390 VSAKFDEYNIPMDTMWLDIEHTDGKRYFT----WDKFKFPHPLAMIKNLTELGRHLVVIVDPHIK 450
            :.|..|. .||:|....||::....:.||    |..|.     ..:|.:.:.|..|::|.||.|:
Worm   316 IQAVRDA-GIPIDIGVADIDYMQRYKDFTTGDDWAGFS-----DYVKTMHDWGMKLILIFDPAIE 374

  Fly   451 RDNNYFFHRDCTDRGY-------YVKTREGNDYE---------GWCWP-GAASYPDFFNPV---- 494
            .....|......:..:       .|:|...|.|.         |..|| ...::|||.:..
Worm   375 ATYPSFQRAIAANAKFIEWETKAQVQTAIQNLYPMAKDTKIMLGVVWPDNHVAFPDFLDSTNNTQ 439

  Fly   495 ---VREY--YASQYALDKFQTVTADVMLWNDMNEPSVF-------------------------NG 529
               :.|:  |.||.|.|.         :|.||||||.|                         ||
Worm   440 NWWINEFVNYQSQVAFDG---------IWIDMNEPSNFGTNQDHPWYFDSDDHPNDAPLFCPTNG 495

  Fly   530 PEITAPKDLIHYGN---WEHRD---------------------------VHNLYGHMHLMGSFAG 564
               ::|.::..|..   |...|                           |.||||....:.:...
Worm   496 ---SSPWEMPPYKTRAVWRFGDANSGAFLSSNTLCMLAQQDGGKQRFYNVKNLYGLTEAINTQKA 557

  Fly   565 LQQRDPNQRPFILTRAHFAGSQRYAAIWTGDNFADWSHLQHSVKMCLTEAVAGFSFCGADVGAFF 629
            | .:...:|..:::|:.:..:.|||..|.|||.|.|..|:.||.......:.|..:.|:||..|.
Worm   558 L-FKATGKRGAVVSRSTYPSAGRYAGHWLGDNTARWEDLRTSVIGAQEFNLFGIPYVGSDVCGFI 621

  Fly   630 GNPDTELLERWYQTGAFLPFFRAHAHIDTKRREPWLFPERTRQVIQNAVIKRYSYLPLWYTAFYE 694
            |....||..||.|.|||..|||.|..|....::|.::|. .....:.|.:.||.|||..::..:.
Worm   622 GTTTEELCLRWQQMGAFHSFFRNHNTIGAPAQDPAVWPS-VAAATKKANLFRYQYLPYLFSLHFT 685

  Fly   695 LELTGEPVIRPLLAQYPLDKEAFGVDNQLLVQDRLLVRPVMQQGVSKVDVYFPAIDDKKNGDWWY 759
            ..|:|..||||:..:||.|.|.|.:..:.:...|:||.||:.||.:.|:.|.|.       |.||
Worm   686 ASLSGATVIRPVFFEYPTDAETFNLGYEFMWGSRILVAPVIYQGTTSVNAYLPT-------DRWY 743

  Fly   760 DVDTYQRQE--RSGYVSVPV-DDFKIPVWQRGGSIVPKKERQRRASTLMLHDPYTLIICLDRQGK 821
            .:..|:...  ..||.:||. ...:|||:.||.|::| ::.....:|....:|:.|:|.....|.
Worm   744 SLFDYRYGSIMSPGYATVPAPTTSRIPVFVRGYSVIP-RQTPSITTTATRSNPFELLIAPCPLGM 807

  Fly   822 ASGSLYLDDEK-------SYAYRQGQRIHVNYEFAHDQLVN------SFVGKPKYKTLAWIERIV 873
            ..|:||.||.:       ||.|.|       ::|.::....      :...|....:|..::.|.
Worm   808 GEGTLYWDDGETIVNDFNSYDYHQ-------FDFMYNSTATGGSVTITHSKKSSKISLPTLDIIE 865

  Fly   874 IAGLEKVPSSASITVNG 890
            |......|:..|.|:||
Worm   866 IFNYPSAPNFRSFTING 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS2alpha	NP_652145.1	GH31_N	224..362	CDD:270212	26/142 (18%)
		Glyco_hydro_31	343..792	CDD:279404	146/537 (27%)
		GH31_GANC_GANAB_alpha	362..833	CDD:269889	152/566 (27%)
aagr-2	NP_494897.3	Trefoil	17..58	CDD:238059	2/6 (33%)
		NtCtMGAM_N	69..175	CDD:374852	28/150 (19%)
		GH31_N	175..287	CDD:270212	33/188 (18%)
		GH31_MGAM_SI_GAA	287..687	CDD:269888	106/419 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54072
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000251
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820