Protein Alignment GCS2alpha and aagr-2

DIOPT Version :10

• Sequence 1: NP_652145.1
• Gene: GCS2alpha / 49953
• FlyBaseID: FBgn0027588
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_494897.3
• Gene: aagr-2 / 173848
• WormBaseID: WBGene00019895
• Length: 955
• Species: Caenorhabditis elegans
• Alignment Length: 992
• Identity: 233/992 - (23%)
• Similarity: 351/992 - (35%)
• Gaps: 275/992 - (27%)

  Fly    12 WALFVLADGVDPGNFKTCEQSSFCRRSRKIQGSGSKYALIPGTLNTYADSLTADLVNKENHHQFA 76
            |..|  .|||   .:....|.......||..|..:.:.         |||....|..|.
 Worm    53 WCYF--KDGV---GYNLDSQQGSTYNLRKNGGPSNPWG---------ADSTEIKLTTKS------ 97

  Fly    77 FKLEALVGSTFRLQIDEKQPLRPRYRVEHALKGPTQAGRIRVQRETDGEIVITSEKNKAVIHGDP 141
                  :||...::|.          ::...:.|....| ..|..|:...:.||..|
 Worm    98 ------IGSVLNVKIG----------IDGRYEPPVDFPR-ETQSSTESLSLSTSFSN-------- 137

  Fly   142 FRIDFFENDVLVVSVNAK------NWLYFEHLRQKAQEPTSHPAENENQQEQDAAVETPKAADTI 200
               ..|...|:..|.|.|      ..|.|..  |..|..|..|:||..
 Worm   138 ---GVFSFSVVRQSTNRKLFDTSIGGLIFSD--QFIQIATYLPSENMY----------------- 180

  Fly   201 DDPGAWEENFKSHHDSKPYGPEAVALDFSFPAAKVLFG--IPEHADSFILKSTSGTDPYRLYNLD 263
                .|.||  :|        :::..||:......:|.  .|.::.|....:..|..||
 Worm   181 ----GWGEN--TH--------QSLRHDFTKYLTWAMFARDQPPNSGSLDTVNLYGVHPY------ 225

  Fly   264 VFEYVV---DSKMALYGSVPVIYGHGAQRTAGVYWQNAAETWVDIQTSETNVVSSLVNFVSGSQK 325
               |::   |.|           .||                |.|..|....|::
 Worm   226 ---YMILEPDGK-----------AHG----------------VLIINSNAQEVTT---------- 250

  Fly   326 TPPPAAHFMSESGIVDAFIMLGPKPMDTFKQYAALTGTHELPQLFALAYHQSRWNYNDERDV-TS 389
            .|.|:..:.:..|.:|.:...||.|....:||....|...||..:||.|..||:.|....:: |.
 Worm   251 APGPSLIYRTIGGNLDMYFFPGPTPEMVTQQYLKFIGKPFLPAYWALGYQLSRYGYKGLAEMKTR 315

  Fly   390 VSAKFDEYNIPMDTMWLDIEHTDGKRYFT----WDKFKFPHPLAMIKNLTELGRHLVVIVDPHIK 450
            :.|..|. .||:|....||::....:.||    |..|.     ..:|.:.:.|..|::|.||.|:
 Worm   316 IQAVRDA-GIPIDIGVADIDYMQRYKDFTTGDDWAGFS-----DYVKTMHDWGMKLILIFDPAIE 374

  Fly   451 RDNNYFFHRDCTDRGY-------YVKTREGNDYE---------GWCWP-GAASYPDFFNPV---- 494
            .....|......:..:       .|:|...|.|.         |..|| ...::|||.:..
 Worm   375 ATYPSFQRAIAANAKFIEWETKAQVQTAIQNLYPMAKDTKIMLGVVWPDNHVAFPDFLDSTNNTQ 439

  Fly   495 ---VREY--YASQYALDKFQTVTADVMLWNDMNEPSVF-------------------------NG 529
               :.|:  |.||.|.|.         :|.||||||.|                         ||
 Worm   440 NWWINEFVNYQSQVAFDG---------IWIDMNEPSNFGTNQDHPWYFDSDDHPNDAPLFCPTNG 495

  Fly   530 PEITAPKDLIHYGN---WEHRD---------------------------VHNLYGHMHLMGSFAG 564
               ::|.::..|..   |...|                           |.||||....:.:...
 Worm   496 ---SSPWEMPPYKTRAVWRFGDANSGAFLSSNTLCMLAQQDGGKQRFYNVKNLYGLTEAINTQKA 557

  Fly   565 LQQRDPNQRPFILTRAHFAGSQRYAAIWTGDNFADWSHLQHSVKMCLTEAVAGFSFCGADVGAFF 629
            | .:...:|..:::|:.:..:.|||..|.|||.|.|..|:.||.......:.|..:.|:||..|.
 Worm   558 L-FKATGKRGAVVSRSTYPSAGRYAGHWLGDNTARWEDLRTSVIGAQEFNLFGIPYVGSDVCGFI 621

  Fly   630 GNPDTELLERWYQTGAFLPFFRAHAHIDTKRREPWLFPERTRQVIQNAVIKRYSYLPLWYTAFYE 694
            |....||..||.|.|||..|||.|..|....::|.::|. .....:.|.:.||.|||..::..:.
 Worm   622 GTTTEELCLRWQQMGAFHSFFRNHNTIGAPAQDPAVWPS-VAAATKKANLFRYQYLPYLFSLHFT 685

  Fly   695 LELTGEPVIRPLLAQYPLDKEAFGVDNQLLVQDRLLVRPVMQQGVSKVDVYFPAIDDKKNGDWWY 759
            ..|:|..||||:..:||.|.|.|.:..:.:...|:||.||:.||.:.|:.|.|.       |.||
 Worm   686 ASLSGATVIRPVFFEYPTDAETFNLGYEFMWGSRILVAPVIYQGTTSVNAYLPT-------DRWY 743

  Fly   760 DVDTYQRQE--RSGYVSVPV-DDFKIPVWQRGGSIVPKKERQRRASTLMLHDPYTLIICLDRQGK 821
            .:..|:...  ..||.:||. ...:|||:.||.|::| ::.....:|....:|:.|:|.....|.
 Worm   744 SLFDYRYGSIMSPGYATVPAPTTSRIPVFVRGYSVIP-RQTPSITTTATRSNPFELLIAPCPLGM 807

  Fly   822 ASGSLYLDDEK-------SYAYRQGQRIHVNYEFAHDQLVN------SFVGKPKYKTLAWIERIV 873
            ..|:||.||.:       ||.|.|       ::|.::....      :...|....:|..::.|.
 Worm   808 GEGTLYWDDGETIVNDFNSYDYHQ-------FDFMYNSTATGGSVTITHSKKSSKISLPTLDIIE 865

  Fly   874 IAGLEKVPSSASITVNG 890
            |......|:..|.|:||
 Worm   866 IFNYPSAPNFRSFTING 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCS2alpha	NP_652145.1	GH31_N	224..362	CDD:270212	26/142 (18%)
		GH31_GANC_GANAB_alpha	362..833	CDD:269889	152/566 (27%)
		DUF5110	809..877	CDD:465360	18/80 (23%)
aagr-2	NP_494897.3	Trefoil	17..58	CDD:238059	2/6 (33%)
		NtCtMGAM_N	69..176	CDD:465286	28/151 (19%)
		GH31_N	175..287	CDD:270212	33/188 (18%)
		GH31_MGAM_SI_GAA	287..687	CDD:269888	106/419 (25%)