DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCS2alpha and Ganab

DIOPT Version :9

Sequence 1:	NP_652145.1	Gene:	GCS2alpha / 49953	FlyBaseID:	FBgn0027588	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_032086.1	Gene:	Ganab / 14376	MGIID:	1097667	Length:	966	Species:	Mus musculus

Alignment Length:	981	Identity:	446/981 - (45%)
Similarity:	601/981 - (61%)	Gaps:	81/981 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ALATVAI----IWALFVLAD---------GVDPGNFKTCEQSSFCRRSRKIQGSGSKYALIPGTL 55
            |:|.||.    .|...|||.         .||..|||||::||||:|.|.|:...|.|..:..||
Mouse     3 AIAAVAARRRRSWLSLVLAYLGVCLGITLAVDRSNFKTCDESSFCKRQRSIRPGLSPYRALLDTL 67

  Fly    56 NTYADSLTADLVNKENHHQFAFKLEALVGSTFRLQIDEKQPLRPRYRVEHALKGPTQAGRIRVQR 120
            ....|:||..|:::........:|:.|..:..|::|||.:|.||||||...|.......|:.|..
Mouse    68 QLGPDALTVHLIHEVTKVLLVLELQGLQKNMTRIRIDELEPRRPRYRVPDVLVADPPTARLSVSG 132

  Fly   121 ETDGEIVITSEKN--KAVIHGDPFRIDFFENDVLVVSVNAKNWLYFEHLRQK------------- 170
            ..|..:.:|..:.  |.::...|||:|..|:..|::||||:..:.|||.|..
Mouse   133 RDDNSVELTVAEGPYKIILTAQPFRLDLLEDRSLLLSVNARGLMAFEHQRAPRVPFSDKVSLALG 197

  Fly   171 ----------AQEPTSHPAENENQQEQ------DAAVETPKAADTIDDPGAWEENFKSHHDSKPY 219
                      :::.:..|||....|.:      |...||.:.|:. |:||||||.||:|.|||||
Mouse   198 SVWDKIKNLFSRQESKDPAEGNGAQPEATPGDGDKPEETQEKAEK-DEPGAWEETFKTHSDSKPY 261

  Fly   220 GPEAVALDFSFPAAKVLFGIPEHADSFILKSTSGTDPYRLYNLDVFEYVVDSKMALYGSVPVIYG 284
            ||.:|.||||.|..:.::||||||||..||.|.|.:||||||||||:|.:::.|||||||||:..
Mouse   262 GPTSVGLDFSLPGMEHVYGIPEHADSLRLKVTEGGEPYRLYNLDVFQYELNNPMALYGSVPVLLA 326

  Fly   285 HGAQRTAGVYWQNAAETWVDI--QTSETNVVSSLVNFVSGSQKTPPPAAHFMSESGIVDAFIMLG 347
            |...|..|::|.|||||||||  .|:...:...:::::.||.:||.....:||||||:|.|:|||
Mouse   327 HSFHRDLGIFWLNAAETWVDISSNTAGKTLFGKMLDYLQGSGETPQTDIRWMSESGIIDVFLMLG 391

  Fly   348 PKPMDTFKQYAALTGTHELPQLFALAYHQSRWNYNDERDVTSVSAKFDEYNIPMDTMWLDIEHTD 412
            |...|.|:|||:||||..||.||:|.||||||||.||.||..|...||::|:|.|.:||||||.|
Mouse   392 PSVFDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHNMPCDVIWLDIEHAD 456

  Fly   413 GKRYFTWDKFKFPHPLAMIKNLTELGRHLVVIVDPHIKRDNNYFFHRDCTDRGYYVKTREGNDYE 477
            ||||||||..:||.||.|:::|....|.||.|||||||.|:.|..|.:..:.|.|||||:|:|||
Mouse   457 GKRYFTWDPTRFPQPLNMLEHLASKRRKLVAIVDPHIKVDSGYRVHEELRNHGLYVKTRDGSDYE 521

  Fly   478 GWCWPGAASYPDFFNPVVREYYASQYALDKFQTVTADVMLWNDMNEPSVFNGPEITAPKDLIHYG 542
            ||||||:||||||.||.:|.::::.::.|.::....::.:||||||||||||||:|..||.:|||
Mouse   522 GWCWPGSASYPDFTNPRMRAWWSNMFSFDNYEGSAPNLYVWNDMNEPSVFNGPEVTMLKDAVHYG 586

  Fly   543 NWEHRDVHNLYG-HMHLMGSFAGLQQRDPN-QRPFILTRAHFAGSQRYAAIWTGDNFADWSHLQH 605
            .|||||:||:|| ::| |.:..||.||... :|||:|:||.|:||||:.|:|||||.|:|.||:.
Mouse   587 GWEHRDIHNIYGLYVH-MATADGLIQRSGGIERPFVLSRAFFSGSQRFGAVWTGDNTAEWDHLKI 650

  Fly   606 SVKMCLTEAVAGFSFCGADVGAFFGNPDTELLERWYQTGAFLPFFRAHAHIDTKRREPWLFPERT 670
            |:.|||:.|:.|.||||||||.||.||:.|||.||||.||:.||||||||:||.||||||...:.
Mouse   651 SIPMCLSLALVGLSFCGADVGGFFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLASQY 715

  Fly   671 RQVIQNAVIKRYSYLPLWYTAFYELELTGEPVIRPLLAQYPLDKEAFGVDNQLLVQDRLLVRPVM 735
            :..|::|:.:|||.||.|||.||:....|.||:|||..|||.|...|.:::|.::.|.||:.||.
Mouse   716 QDAIRDALFQRYSLLPFWYTLFYQAHKEGFPVMRPLWVQYPEDMSTFSIEDQFMLGDALLIHPVS 780

  Fly   736 QQGVSKVDVYFPAIDDKKNGDWWYDVDTYQRQERSGYVSVPVDDFKIPVWQRGGSIVPKKERQRR 800
            ..|...|.||.|..::.     |||:.:||:......:.:||....|||:||||:|||:..|.||
Mouse   781 DAGAHGVQVYLPGQEEV-----WYDIQSYQKHHGPQTLYLPVTLSSIPVFQRGGTIVPRWMRVRR 840

  Fly   801 ASTLMLHDPYTLIICLDRQGKASGSLYLDDEKSYAYRQGQRIHVNYEFAHDQLVN--SFVGK--- 860
            :|..|..||.||.:.|..||.|.|.|:|||..::          ||:..|:.|:.  ||.|.
Mouse   841 SSDCMKDDPITLFVALSPQGTAQGELFLDDGHTF----------NYQTRHEFLLRRFSFSGSTLV 895

  Fly   861 -----PK--YKTLAWIERIVIAGLEKVPSSASITVNGVSQQLEVLHHD---NTVVVRKPGVKMDV 915
                 ||  .:|..||||:||.|..| |::..:...|..:......||   :.:::|||||.:..
Mouse   896 SSSADPKGHLETPIWIERVVIMGAGK-PAAVVLQTKGSPESRLSFQHDPETSVLILRKPGVSVAS 959

  Fly   916 DFAIKL 921
            |::|.|
Mouse   960 DWSIHL 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS2alpha	NP_652145.1	GH31_N	224..362	CDD:270212	74/139 (53%)
		Glyco_hydro_31	343..792	CDD:279404	244/450 (54%)
		GH31_GANC_GANAB_alpha	362..833	CDD:269889	253/472 (54%)
Ganab	NP_032086.1	GH31_N	264..406	CDD:270212	74/141 (52%)
		Glyco_hydro_31	387..832	CDD:279404	244/450 (54%)
		GH31_GANC_GANAB_alpha	406..873	CDD:269889	253/472 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	542	1.000	Domainoid score	I264
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5426
Inparanoid	1	1.050	874	1.000	Inparanoid score	I408
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54072
OrthoDB	1	1.010	-	-		D100626at2759
OrthoFinder	1	1.000	-	-		FOG0000251
OrthoInspector	1	1.000	-	-		otm44348
orthoMCL	1	0.900	-	-		OOG6_100592
Panther	1	1.100	-	-	LDO	PTHR22762
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R499
SonicParanoid	1	1.000	-	-		X1016
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.870