DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GCS2alpha and ganc

DIOPT Version :9

Sequence 1:	NP_652145.1	Gene:	GCS2alpha / 49953	FlyBaseID:	FBgn0027588	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_021323148.1	Gene:	ganc / 100536353	ZFINID:	ZDB-GENE-130530-754	Length:	916	Species:	Danio rerio

Alignment Length:	894	Identity:	360/894 - (40%)
Similarity:	500/894 - (55%)	Gaps:	79/894 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 FKTCEQSSFCRRSRKIQGSGSKYALIPGTLNTYADSLTADLVNKENHHQFAFKLEALVGSTFRLQ 90
            |:...:..|.||.|  ..:.|:|.....|........:.:|..:::..:.:.::.|....|.|:.
Zfish    20 FRKNHEILFYRRQR--DKAVSQYFTSYETFVLTDGGASLELCERDSQDRLSLQIRATQNGTIRVS 82

  Fly    91 IDEKQPLRPRYRVEHALKGPTQAGRIRVQRETDGEIVIT--SEKNKAVIHGDPFRIDFFENDVLV 153
            |||.|.::|||:|...|.|..:...:||:.:.:..:.:|  ..:.:.:....||:::.......:
Zfish    83 IDELQLVKPRYQVSDVLVGELRYEPLRVEWKKEDCVCLTWGLGQYQLLAFFSPFKLEISCAGEEI 147

  Fly   154 VSVNAKNWLYFEHLRQKAQEPTSHPAENENQQEQDAAVETPKAADTIDDPGAWEENFKSHHDSKP 218
            |::|..|.|.||.|    |:|.|..:.|.::.:::..             |.|:|.|:...|.|.
Zfish   148 VTLNPGNKLCFETL----QDPASRSSSNSSEGDENCC-------------GLWKETFRQFEDIKA 195

  Fly   219 YGPEAVALDFSFPAAKVLFGIPEHADSFILKSTSGTDPYRLYNLDVFEYVVDSKMALYGSVPVIY 283
            .||.:|.||.|.......:|:|||||:.:||.||.::.|||||||||.|.::|::.||||||::.
Zfish   196 NGPSSVGLDLSLHGFNHTYGVPEHADTLLLKDTSVSEAYRLYNLDVFGYEINSRLGLYGSVPLLL 260

  Fly   284 GHGAQRTAGVYWQNAAETWVDIQTSETNVVSSLVNFVSGSQKTPPPA----------AHFMSESG 338
            .|..:|||||:|.|::||.||::          .|......:..||.          ..::||||
Zfish   261 AHKPERTAGVFWLNSSETLVDVK----------YNTEQNEDEDEPPGKKSRISPRTDVRWISESG 315

  Fly   339 IVDAFIMLGPKPMDTFKQYAALTGT------------------HELPQLFALAYHQSRWNYNDER 385
            .:|.||:|||.|...|.|||.|||.                  ..||.||:|..||.||||.||.
Zfish   316 TIDCFILLGPTPAQVFSQYAQLTGKCRCRLYNGCARNRPLLSYQALPPLFSLGNHQCRWNYEDEA 380

  Fly   386 DVTSVSAKFDEYNIPMDTMWLDIEHTDGKRYFTWDKFKFPHPLAMIKNLTELGRHLVVIVDPHIK 450
            ||.:|.|.||.:.||.|.:||||||||||||||||..:||:|..:..:|.:..|.||||.|||||
Zfish   381 DVKAVDAGFDLHGIPYDVIWLDIEHTDGKRYFTWDSKRFPNPAELQHHLMKKKRKLVVISDPHIK 445

  Fly   451 RDNNYFFHRDCTDRGYYVKTREGNDYEGWCWPGAASYPDFFNPVVREYYASQYALDKFQTVTADV 515
            .|.::..:.:....|::||.|||.|:||.||||.:.|.||.:...|.:||.|::|.|::..|..:
Zfish   446 MDPDWSIYCEAKKGGHFVKNREGFDFEGTCWPGESCYLDFSSSKTRLWYARQFSLSKYEGSTESL 510

  Fly   516 MLWNDMNEPSVFNGPEITAPKDLIHYGNWEHRDVHNLYGHMHLMGSFAGLQQRD-PNQRPFILTR 579
            .:||||||||||||||.|.|||.:|:|.||||::|||||....|.:|.||..|. ..:|||||||
Zfish   511 FVWNDMNEPSVFNGPEQTMPKDALHHGGWEHRELHNLYGFYQHMATFEGLLTRSGGTERPFILTR 575

  Fly   580 AHFAGSQRYAAIWTGDNFADWSHLQHSVKMCLTEAVAGFSFCGADVGAFFGNPDTELLERWYQTG 644
            :.||||||..|||||||.|.|.:|:.|:.|.|:.::.|..|||||||.|..:||.|||.||||.|
Zfish   576 SFFAGSQRLGAIWTGDNVATWEYLKISIPMLLSLSLTGIQFCGADVGGFVQDPDPELLVRWYQAG 640

  Fly   645 AFLPFFRAHAHIDTKRREPWLFPERTRQVIQNAVIKRYSYLPLWYTAFYELELTGEPVIRPLLAQ 709
            |..||||||:...|||||||||.|.....|::||..||..||.|||.|::......|.||||..:
Zfish   641 ALQPFFRAHSAKMTKRREPWLFGEEVTSAIRSAVQDRYCLLPYWYTLFHQAHTAALPPIRPLWVE 705

  Fly   710 YPLDKEAFGVDNQLLVQDRLLVRPVMQQGVSKVDVYFPAIDDKKNGDWWYDVDTYQRQERSGYVS 774
            :|.|...|.|:||.::...|||.||...||::|.|..|.     :.:.|||.:|.:..:.:..:.
Zfish   706 FPKDTSTFAVENQYMIGGALLVCPVTDPGVTEVKVLLPG-----SNELWYDTNTSEVHKGARSLD 765

  Fly   775 VPVDDFKIPVWQRGGSIVPKKERQRRASTLMLHDPYTLIICLDRQGKASGSLYLDDEKSYAYR-Q 838
            |||....:.|:||||::||::......:..:.|...||.:.||.:|||.|.|||||..|:.|| |
Zfish   766 VPVTLTTVLVFQRGGTVVPRRTACGSCTADLQHYTITLTVALDIKGKADGFLYLDDGHSFNYRDQ 830

  Fly   839 GQRIHVNYEFAHDQLVNS-------FVGKPKYKTLAWIERIVIAGLEKV 880
            .|.....:.....:||||       ||...|      :|.:||.||:.|
Zfish   831 MQFCLRRFSMQAGRLVNSCANDKGLFVSDDK------VETVVILGLKSV 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS2alpha	NP_652145.1	GH31_N	224..362	CDD:270212	62/147 (42%)
		Glyco_hydro_31	343..792	CDD:279404	229/467 (49%)
		GH31_GANC_GANAB_alpha	362..833	CDD:269889	233/489 (48%)
ganc	XP_021323148.1	GH31_N	201..339	CDD:270212	62/147 (42%)
ganc	XP_021323148.1	GH31_GANC_GANAB_alpha	358..824	CDD:269889	232/470 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582102
Domainoid	1	1.000	532	1.000	Domainoid score	I270
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54072
OrthoDB	1	1.010	-	-		D100626at2759
OrthoFinder	1	1.000	-	-		FOG0000251
OrthoInspector	1	1.000	-	-		otm24289
orthoMCL	1	0.900	-	-		OOG6_100592
Panther	1	1.100	-	-	O	PTHR22762
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1016
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.720