DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCS2alpha and gaa

DIOPT Version :9

Sequence 1:	NP_652145.1	Gene:	GCS2alpha / 49953	FlyBaseID:	FBgn0027588	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_031750241.1	Gene:	gaa / 100495955	XenbaseID:	XB-GENE-6054131	Length:	901	Species:	Xenopus tropicalis

Alignment Length:	782	Identity:	218/782 - (27%)
Similarity:	340/782 - (43%)	Gaps:	109/782 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 TIDDPGAWEENFKSHHDSKPYGPEAVALDFSFPAAKVLFGIPEHADSF---ILKSTSGTDPYRLY 260
            ||.||.           .|.|.........|..|:..||.:....|.|   |.:.:||   ..|.
Frog   141 TIKDPA-----------KKRYEVPIPTPQVSGKASSTLFDVQFSCDPFGLIIRRKSSG---LILL 191

  Fly   261 NLDVFEYV-VDSKMALYGSVP--VIYGHGAQRTA---GVYWQNAAETW-VDIQTS-ETNVVSSLV 317
            |..|...: .|..:.:..|:|  .:||.|...||   .:.| |....| .|::.| ::|:..|..
Frog   192 NTTVAPLIFADQFLQISTSLPSGYLYGLGEHLTALNLSLQW-NRLTFWNRDLRPSKDSNLYGSHP 255

  Fly   318 NFVS---GSQK---------------TPPPAAHFMSESGIVDAFIMLGPKPMDTFKQYAALTGTH 364
            .::|   |.|.               ...||..:.:..||:|.::.|||:|....:||..:.|..
Frog   256 FYLSMEEGGQSHGVFLLNSNAMDVLLQEAPALTWRTTGGILDFYVFLGPEPKSVIRQYQDIIGYP 320

  Fly   365 ELPQLFALAYHQSRWNYNDERDVTSVSAKFDEYNIPM-----DTMWLDIEHTDGKRYFTWDKFKF 424
            .:|..::|.:|..||.|:.......|.....:..||:     |..|.||::.|..|.||:|:.:|
Frog   321 FMPPYWSLGFHLCRWGYSTSNCTRQVVKNMRDAKIPLLFSLQDVQWNDIDYMDAMRDFTYDQNRF 385

  Fly   425 PHPLAMIKNLTELGRHLVVIVDPHIKRDN---NYFFHRDCTDRGYYVKTREGNDYEGWCWPGAAS 486
            .....|:|...:.|...::|:||.|...|   :|..:.|...||.::...||....|..|||...
Frog   386 GDFPEMVKEFHQQGVKYIMILDPAISSSNTPGSYPPYDDGLKRGVFITDDEGKPLVGKVWPGLTV 450

  Fly   487 YPDFFNPVVREYYASQYALDK-FQTVTADVMLWNDMNEPSVF--------------NGPEI---- 532
            :|||..|   |.::..|.:.| |........:|.||||||.|              |.|.:
Frog   451 FPDFTMP---ETFSWWYDMVKLFHDQVPFDGIWIDMNEPSNFVQGSVDGCPNNELENPPYVPGVV 512

  Fly   533 --------TAPKDLIHYGNWEHRDVHNLYGHMHLMGSFAGLQQRDPNQRPFILTRAHFAGSQRYA 589
                    .......|..:  |.::|||||....:.:...| .:...:||||::|:.||....||
Frog   513 GGSLRSTTICASSQQHLSS--HYNLHNLYGLSEAVATHYAL-VKILKKRPFIISRSTFASHGHYA 574

  Fly   590 AIWTGDNFADWSHLQHSVKMCLTEAVAGFSFCGADVGAFFGNPDTELLERWYQTGAFLPFFRAHA 654
            ..||||..:.|..:.:||...|...:.|....|||:..|.||...||..||.|.|||.||.|.|.
Frog   575 GHWTGDVVSSWEQIYYSVPAILLFNMFGVPMVGADICGFGGNTTEELCVRWSQLGAFYPFMRNHN 639

  Fly   655 HIDTKRREPWLFPERTRQVIQNAVIKRYSYLPLWYTAFYELELTGEPVIRPLLAQYPLDKEAFGV 719
            ..|:..:||::|....::.|::|::.||:.||..||.|::...:||.|.|.|..::|.|...:.:
Frog   640 DHDSVSQEPYVFSSEAQKAIKSALLIRYTLLPYLYTLFHKAHSSGETVARALFIEFPTDPNTWTI 704

  Fly   720 DNQLLVQDRLLVRPVMQQGVSKVDVYFPAIDDKKNGDWWYDVDTYQRQERSGYVSVPVDDFKIPV 784
            |.|.|..:.||:.||::||.:.|:.|||      .|.|:........|.:..::.:|....||.|
Frog   705 DRQYLWGEALLITPVLEQGKTTVNAYFP------TGTWYAPESGTGIQSKGQWLMLPAPLDKINV 763

  Fly   785 WQRGGSIVPKK------ERQRRASTLMLHDPYTLIICLDRQGKASGSLYLDDEKSY-AYRQGQRI 842
            ..|||.|:|.:      |..|:...|       |::.|...|.|.|.|:.||..|. .:.:....
Frog   764 HIRGGYILPAQVPGMNTEESRKNKLL-------LVVALTPDGVARGDLFWDDGVSLGTFERQDYT 821

  Fly   843 HVNYEFAHDQLVNSFVGKPKYKTLAWIERIVIAGLEKVPS-SASITVNGVSQQLEVLHHDNTVVV 906
            ||.:..|::.|:|..:   :..:.|...::.:..:..||| ...:.:||::.:......|..|::
Frog   822 HVVFLAANNILLNELI---RVNSQADGLKLGMVNVYGVPSPPKKVLINGIASEDYSYTLDTKVLI 883

  Fly   907 RK 908
            .|
Frog   884 IK 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS2alpha	NP_652145.1	GH31_N	224..362	CDD:270212	41/166 (25%)
		Glyco_hydro_31	343..792	CDD:279404	149/483 (31%)
		GH31_GANC_GANAB_alpha	362..833	CDD:269889	156/511 (31%)
gaa	XP_031750241.1	Trefoil	44..89	CDD:395041
		NtCtMGAM_N	106..212	CDD:407105	20/84 (24%)
		GH31_N	205..318	CDD:270212	28/113 (25%)
		GH31_MGAM_SI_GAA	318..681	CDD:269888	113/368 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000251
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000