DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCS2alpha and ganab

DIOPT Version :9

Sequence 1:	NP_652145.1	Gene:	GCS2alpha / 49953	FlyBaseID:	FBgn0027588	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_004919758.2	Gene:	ganab / 100492576	XenbaseID:	XB-GENE-997256	Length:	979	Species:	Xenopus tropicalis

Alignment Length:	957	Identity:	446/957 - (46%)
Similarity:	602/957 - (62%)	Gaps:	44/957 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RFALATVAIIWALFVLADGVDPGNFKTCEQSSFCRRSRKIQGSGSKYALIPGTLNTYADSLTADL 66
            |..|....:....|:.|..||..|||||:|||||:|.||:|...|.|....|:....:|.|...|
Frog    29 RRLLGAALLFTVCFIPALTVDKSNFKTCDQSSFCQRQRKLQPGLSTYRAALGSAKLSSDKLEVQL 93

  Fly    67 VNKENHHQFAFKLEALVGSTFRLQIDEKQPLRPRYRVEHALKGPTQAGRIRVQRETDG--EIVIT 129
            ::..|......::..|.|:..|::|:|..||:|||.|...|.|......::|..:.|.  |:.:.
Frog    94 IDDRNQASLLLEVYGLDGNMTRIKINEINPLKPRYEVPDVLVGTPLPANLQVTGQDDNTLELSLG 158

  Fly   130 SEKNKAVIHGDPFRIDFFENDVLVVSVNAKNWLYFEHLRQKA----------------------- 171
            ...:|.::.|.|||:|......||:|||::..|:|||||::.
Frog   159 ETGHKLLVTGTPFRLDILSGQDLVLSVNSRGLLHFEHLRERKDTLSAKVSSAVGNMWHKMKTLFS 223

  Fly   172 --QEPTSHPAENE--NQQEQDAAVETPKAADTIDDPGAWEENFKSHHDSKPYGPEAVALDFSFPA 232
              .|....|||.|  |.:|.::..|.......:|:||.|:|.||:|.||||.||.:|.||||.|.
Frog   224 SDSEKKDVPAETEEANAEELESVKEEESKKPEVDEPGMWDETFKTHTDSKPNGPSSVGLDFSLPG 288

  Fly   233 AKVLFGIPEHADSFILKSTSGTDPYRLYNLDVFEYVVDSKMALYGSVPVIYGHGAQRTAGVYWQN 297
            .:.::|||||||:..|::|.|||||||||||||:|.:.:.||||||||::..|..:||.|::|.|
Frog   289 FENVYGIPEHADNMKLRTTEGTDPYRLYNLDVFQYDLYNTMALYGSVPLLLAHNVKRTLGIFWLN 353

  Fly   298 AAETWVDIQT--SETNVVSSLVNFVSGSQKTPPPAAHFMSESGIVDAFIMLGPKPMDTFKQYAAL 360
            ||||||||.:  :...::..::.::.|..:||.....:||||||:|.|::|||.|.|.|||||:|
Frog   354 AAETWVDISSNIAGKTLLGKMLQYMQGGGETPQTDVRWMSESGIIDVFLLLGPSPFDVFKQYASL 418

  Fly   361 TGTHELPQLFALAYHQSRWNYNDERDVTSVSAKFDEYNIPMDTMWLDIEHTDGKRYFTWDKFKFP 425
            |||..||..|:|.|||.|||||||.||.:|.|.|||:::|.|.:||||||.|||||||||..|||
Frog   419 TGTQALPPYFSLGYHQCRWNYNDEEDVRNVDAGFDEHDLPYDVIWLDIEHADGKRYFTWDPHKFP 483

  Fly   426 HPLAMIKNLTELGRHLVVIVDPHIKRDNNYFFHRDCTDRGYYVKTREGNDYEGWCWPGAASYPDF 490
            :|..|:..|....|.:|.|||||||.|:.|..|.|...:..|:||::|:|||||||||:|:||||
Frog   484 NPRDMLSGLKNKRRKMVAIVDPHIKIDSGYRIHNDIRSQNLYIKTKDGSDYEGWCWPGSAAYPDF 548

  Fly   491 FNPVVREYYASQYALDKFQTVTADVMLWNDMNEPSVFNGPEITAPKDLIHYGNWEHRDVHNLYGH 555
            .||.:|:::||.:|.||::....::.:||||||||||||||:|..||.:|:|.|||||||||||.
Frog   549 TNPEMRKWWASMFAYDKYEGSMDNLFVWNDMNEPSVFNGPEVTMHKDAVHWGGWEHRDVHNLYGF 613

  Fly   556 MHLMGSFAGLQQRD-PNQRPFILTRAHFAGSQRYAAIWTGDNFADWSHLQHSVKMCLTEAVAGFS 619
            .....:..||.||. ..:|||:||||.|||||||.|:|||||.|:|.||:.|:.|||:.::.|.|
Frog   614 YVQRATSEGLIQRSGGKERPFVLTRAFFAGSQRYGAVWTGDNAAEWDHLKISIPMCLSLSLVGIS 678

  Fly   620 FCGADVGAFFGNPDTELLERWYQTGAFLPFFRAHAHIDTKRREPWLFPERTRQVIQNAVIKRYSY 684
            |||||||.||.|||.|||.||||.||:.||||||||:||.||||||..:....||:.|:.:||:.
Frog   679 FCGADVGGFFKNPDAELLVRWYQAGAYQPFFRAHAHLDTPRREPWLHGDDNMAVIREALRQRYTL 743

  Fly   685 LPLWYTAFYELELTGEPVIRPLLAQYPLDKEAFGVDNQLLVQDRLLVRPVMQQGVSKVDVYFPAI 749
            ||.|||.||.....||||:|||..::|.|...|.:|:..::...||||||.:.....|.:|.|.
Frog   744 LPFWYTLFYRALREGEPVMRPLWVEFPSDASTFAMDSHYMLGSALLVRPVTEAKARGVQIYLPG- 807

  Fly   750 DDKKNGDWWYDVDTYQRQERSGYVSVPVDDFKIPVWQRGGSIVPKKERQRRASTLMLHDPYTLII 814
                :|:.||||.:|||.|......:||....|||:||||||:|:|:|.||:|..|..||:||.:
Frog   808 ----DGEVWYDVHSYQRYEAPQTFYLPVTMNSIPVYQRGGSIIPRKDRPRRSSDCMKDDPFTLYV 868

  Fly   815 CLDRQGKASGSLYLDDEKSYAYRQGQRIHVNYEFAHDQLVNSFVGKPK--YKTLAWIERIVIAGL 877
            .|:.||:|.|.|:|||..|:.|.|.:.::..:.::..:|..|.: .|.  :||.:|||||:|.|.
Frog   869 ALNVQGEARGELFLDDGHSFNYEQNEFLYREFNYSQGKLTASSL-DPSGVFKTASWIERIIIIGA 932

  Fly   878 EKVPSSASITVNGVSQQLEVLHHDNT---VVVRKPGVKMDVDFAIKL 921
            .| |:|..:|:.|.|:......:|.|   ..||||||.:..||.:.|
Frog   933 TK-PASVMLTLPGGSESALEFEYDQTTSVTTVRKPGVNIASDFTVSL 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS2alpha	NP_652145.1	GH31_N	224..362	CDD:270212	73/139 (53%)
		Glyco_hydro_31	343..792	CDD:279404	250/449 (56%)
		GH31_GANC_GANAB_alpha	362..833	CDD:269889	258/471 (55%)
ganab	XP_004919758.2	GH31_N	280..420	CDD:270212	73/139 (53%)
ganab	XP_004919758.2	GH31_GANC_GANAB_alpha	420..887	CDD:269889	258/471 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	549	1.000	Domainoid score	I252
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5426
Inparanoid	1	1.050	901	1.000	Inparanoid score	I376
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D100626at2759
OrthoFinder	1	1.000	-	-		FOG0000251
OrthoInspector	1	1.000	-	-		otm49526
Panther	1	1.100	-	-	LDO	PTHR22762
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1016
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160