DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCS2alpha and ganaba

DIOPT Version :9

Sequence 1:	NP_652145.1	Gene:	GCS2alpha / 49953	FlyBaseID:	FBgn0027588	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_009300299.1	Gene:	ganaba / 100126019	ZFINID:	ZDB-GENE-070928-36	Length:	984	Species:	Danio rerio

Alignment Length:	950	Identity:	440/950 - (46%)
Similarity:	588/950 - (61%)	Gaps:	56/950 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VAIIWALFVLADGVDPGNFKTCEQSSFCRRSRKIQGSGSKYALIPGTLNTYADSLTADLVNKENH 72
            |.:::.|||.|..||..|||||:|||||:|.|:::...|.|..:..||......||..|:|..|.
Zfish     9 VLLLFLLFVSAQAVDRSNFKTCDQSSFCKRQRELKPGQSPYRALLDTLELSDSRLTLQLINDNNK 73

  Fly    73 HQFAFKLEALVGSTFRLQIDEKQPLRPRYRVEHALKGPTQAGRIRVQRETDGEIVIT--SEKNKA 135
            .:...:|..|.|:..|::|:|.:|::|||.|...|........:.|..:.|..:|::  ..:.:.
Zfish    74 VRLLLELYRLQGNMTRVKINELKPIKPRYEVPDVLISDPITEALSVVSQDDNSLVLSLGGNEQRL 138

  Fly   136 VIHGDPFRIDFFENDVLVVSVNAKNWLYFEHLR---------------------------QKAQE 173
            ::...|||:|..|...:::|:|::..|.|||||                           ....|
Zfish   139 IVSAQPFRLDIIEGPQVLMSLNSRGLLAFEHLRVRKDTISHKISSTVGSMWDSIKSVFSSNSESE 203

  Fly   174 PTSHPAENENQQEQDAAVETPKAADTIDDPGAWEENFKSHHDSKPYGPEAVALDFSFPAAKVLFG 238
            .|:...:.|.|..:|..:   |..:..:.||.|||.||||.||||.||.:::||||.|..:.::|
Zfish   204 ETTGQQKEEQQTSEDGQI---KEEEEEEKPGMWEETFKSHSDSKPNGPSSISLDFSLPGVEHVYG 265

  Fly   239 IPEHADSFILKSTSGTDPYRLYNLDVFEYVVDSKMALYGSVPVIYGHGAQRTAGVYWQNAAETWV 303
            ||||||:..||||..:|||||||||||:|.:.:.|||||:|||:..|..:||.|::|.|||||||
Zfish   266 IPEHADTLRLKSTENSDPYRLYNLDVFQYELHNPMALYGAVPVLISHSTERTMGIFWLNAAETWV 330

  Fly   304 DIQTSETNVVSSLVNFVSGSQKTPPPAAHFMSESGIVDAFIMLGPKPMDTFKQYAALTGTHELPQ 368
            ||.::..:.|||         ..|.....::|||||:|.||||||||.|.|.|||:||||...|.
Zfish   331 DISSNSPDTVSS---------DAPQTNVRWVSESGIIDVFIMLGPKPADVFTQYASLTGTQSFPP 386

  Fly   369 LFALAYHQSRWNYNDERDVTSVSAKFDEYNIPMDTMWLDIEHTDGKRYFTWDKFKFPHPLAMIKN 433
            |.||||||.||||||:.||.:|...|||::||.|.:||||||.|||||||||..|||.|..|:|.
Zfish   387 LSALAYHQCRWNYNDQEDVKAVDQGFDEHDIPYDFIWLDIEHADGKRYFTWDPIKFPTPKDMLKG 451

  Fly   434 LTELGRHLVVIVDPHIKRDNNYFFHRDCTDRGYYVKTREGNDYEGWCWPGAASYPDFFNPVVREY 498
            |.:..|.||.||||||:.|:.|..|.:...:.:|||.::|.|||||||||.:.||||.||.:|.:
Zfish   452 LMDKRRKLVAIVDPHIRVDSGYRIHNEIRSKNFYVKNKDGGDYEGWCWPGNSGYPDFTNPEMRAW 516

  Fly   499 YASQYALDKFQTVTADVMLWNDMNEPSVFNGPEITAPKDLIHYGNWEHRDVHNLYGHMHLMGSFA 563
            :||.:|.|:::....:..:||||||||||||||:|..||.:| |.|||||||||||......:..
Zfish   517 WASMFAYDQYEGSMENQYIWNDMNEPSVFNGPEVTMHKDAVH-GVWEHRDVHNLYGLYVQKATSE 580

  Fly   564 GLQQRDPN-QRPFILTRAHFAGSQRYAAIWTGDNFADWSHLQHSVKMCLTEAVAGFSFCGADVGA 627
            ||.||... :|||:||||.|||||||.|:|||||.|:|.||:.|:.|||:..:.|.||||||||.
Zfish   581 GLIQRSGGVERPFVLTRAFFAGSQRYGAVWTGDNAAEWGHLKISIPMCLSLGLVGISFCGADVGG 645

  Fly   628 FFGNPDTELLERWYQTGAFLPFFRAHAHIDTKRREPWLF-PERTRQVIQNAVIKRYSYLPLWYTA 691
            ||.:|..|||.||||.||:.|||||||||||.||||||| ||.| .:|:.||.:||:.||.||..
Zfish   646 FFKHPSAELLVRWYQAGAYQPFFRAHAHIDTPRREPWLFGPENT-ALIREAVRQRYALLPNWYQL 709

  Fly   692 FYELELTGEPVIRPLLAQYPLDKEAFGVDNQLLVQDRLLVRPVMQQGVSKVDVYFPAIDDKKNGD 756
            ||....||:||:|||..:||.:...|.::::.|:...|||.||..:|.:.|..|.|.     .|:
Zfish   710 FYNAHNTGQPVMRPLWVEYPAEVTTFSIEDEYLIGKDLLVHPVTDEGATGVTAYLPG-----KGE 769

  Fly   757 WWYDVDTYQRQERSGYVSVPVDDFKIPVWQRGGSIVPKKERQRRASTLMLHDPYTLIICLDRQGK 821
            .||||.:.|:.:....:.:||....|||:||||||:.:|||.||:|:.|.:|||||.:.|:.||.
Zfish   770 VWYDVHSLQKHDGDQSLYIPVTMSSIPVFQRGGSIICRKERVRRSSSCMENDPYTLYVALNSQGF 834

  Fly   822 ASGSLYLDDEKSYAYRQG-QRIHVNYEFAHDQLVN-SFVGKPKYKTLAWIERIVIAGLEKVPSSA 884
            |.|.||:||..::.|::. |.||....|:::.|.: :.....::.|.:||||||:.|..: |||.
Zfish   835 AEGELYIDDFHTFNYQKSKQFIHRRLSFSNNSLTSRNLAPDAQFSTESWIERIVVIGGSR-PSSV 898

  Fly   885 S-ITVNGVSQQLEVLHHDNTVV--VRKPGVKMDVDFAIKL 921
            | |..:||...||.....|..|  ||||.|....|:.:.|
Zfish   899 SLINADGVESALEFEFSSNPAVLTVRKPSVSAAADWTVVL 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS2alpha	NP_652145.1	GH31_N	224..362	CDD:270212	74/137 (54%)
		Glyco_hydro_31	343..792	CDD:279404	249/450 (55%)
		GH31_GANC_GANAB_alpha	362..833	CDD:269889	256/472 (54%)
ganaba	XP_009300299.1	GH31_N	251..380	CDD:270212	74/137 (54%)
		Glyco_hydro_31	361..805	CDD:279404	249/450 (55%)
		GH31_GANC_GANAB_alpha	380..846	CDD:269889	256/472 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	532	1.000	Domainoid score	I270
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	868	1.000	Inparanoid score	I400
OMA	1	1.010	-	-		QHG54072
OrthoDB	1	1.010	-	-		D100626at2759
OrthoFinder	1	1.000	-	-		FOG0000251
OrthoInspector	1	1.000	-	-		otm24289
orthoMCL	1	0.900	-	-		OOG6_100592
Panther	1	1.100	-	-	O	PTHR22762
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1016
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980