DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brsk1 and par-1

DIOPT Version :9

Sequence 1:	NP_001120809.1	Gene:	Brsk1 / 499073	RGDID:	1563268	Length:	778	Species:	Rattus norvegicus
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	844	Identity:	243/844 - (28%)
Similarity:	367/844 - (43%)	Gaps:	180/844 - (21%)

- Green bases have known domain annotations that are detailed below.

  Rat    29 QYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAVKIVNREKLSESVLMKVEREIAILKLIEHPHV 93
            :::|.|:|.||:|||....|||..|..||::||:||:::.:|:...|.|:.||:.|:|:::||::
  Fly   248 EHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNI 312

  Rat    94 LKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLK 158
            :||..|.|.:|.|||::|:.||||:|||||..||:..||||..|||||||:.:||...|.|||||
  Fly   313 VKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLK 377

  Rat   159 PENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFA 223
            .||||||.:.||:|||||.::.....|.|:|.||||.||.||:.:|:||||...|:||.||||:.
  Fly   378 AENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYT 442

  Rat   224 LLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGG 288
            |:.|:||||...||:|.|:|.||.:.:|.::..||::|||..:.:.|.||.|||.|....|...|
  Fly   443 LVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMG 507

  Rat   289 KHEPD--PCLEPAPGRRVAMRSLPSNGEL-DPDVLESMASLGCFRDRERLHRELRSEEENQEKMI 350
            ..|.:  |.:||             ..:| ||..:|::.::|  .:|..:...| |:....:...
  Fly   508 FEEDELKPYIEP-------------KADLADPKRIEALVAMG--YNRSEIEASL-SQVRYDDVFA 556

  Rat   351 YYLLLDRKERYP----SCEDQDLPPRN-------------DVDPPRKRVDSPMLSRHGKRRPERK 398
            .||||.||...|    |.....|..||             .|..|..|.....:|. ...:|.|:
  Fly   557 TYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSISA-SSTKPSRR 620

  Rat   399 SMEVLSITDA--------GSGGSPVPT-------------------------------RRALEMA 424
            :...:..|:|        |:.|:..|:                               .....:|
  Fly   621 ASSGVGPTNAAATVAAATGAVGAVNPSNNYNAAGSAADRASVGSNFKRQNTIDSATIKENTARLA 685

  Rat   425 QHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGVGDEARGG---------------GSPTSK 474
            ..:||..|.:......:.:.|:||..|..:...:|..|:....|               .|.|.|
  Fly   686 AQNQRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSGIIPRRSTTLYEKTSSTEK 750

  Rat   475 TQTLPSRGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPS 539
            |..:|:...............|:|..|...|..|...||.|...:......:..:|..|.:..|
  Fly   751 TNVIPAETNLFDRLRMASAVKSSRHFPRNVPSRSTFHSGQTRARNNTALEYSGTSGASGDSSHP- 814

  Rat   540 PGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPT-AEEMSSLTPESSPELAKRSWFGNFISLD 603
                 |..::.|:|:|         ||.:|    || |:|      .:.|.:.:.:|.....|..
  Fly   815 -----GRMSFFSKLSS---------RFSKR----PTIADE------AAKPRVLRFTWSMKTTSPL 855

  Rat   604 KEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYK-------ASGGPSVFQKPV 661
            ..:||...:::                       ||.|.:...|.:       ..|.|:. ...|
  Fly   856 MPDQIMQKIRE-----------------------VLDQNNCDYEQRERFVLWCVHGDPNT-DSLV 896

  Rat   662 RFQVDISSSEGPEPSPRRDGSSGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQALA 726
            ::::::..      .||.      .:..|.|..|||.|..||.:...|...|.. .:|.:
  Fly   897 QWEIEVCK------LPRL------SLNGVRFKRISGTSIGFKNIASRIAFDLKLXLNQTN----- 944

  Rat   727 DEKNGAQTRPAGTPPRSLQPPPG--RPDPDLSS------------SPRRGPSKDKK-LLATNGT 775
            :|.|.|.|....|.|........  ||..|.:|            :.::|..:.|| .|:|.|:
  Fly   945 NEGNAAATASRPTDPTDTMTTTNCRRPSNDSTSRLSELSLLCRSLTSQQGSQRRKKSRLSTGGS 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brsk1	NP_001120809.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		243/844 (29%)
		STKc_BRSK1_2	32..285	CDD:270983	128/252 (51%)
		S_TKc	34..284	CDD:214567	127/249 (51%)
		UBA_BRSK	314..367	CDD:270525	16/57 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..548		44/256 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	719..778		17/72 (24%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	127/251 (51%)
		S_TKc	253..504	CDD:214567	127/250 (51%)
		UBA_MARK_Par1	525..563	CDD:270522	11/40 (28%)
		MARK1-3_C	839..936	CDD:213381	23/132 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D302185at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920