Protein Alignment SIX6 and Six4

DIOPT Version :9

• Sequence 1: NP_031400.2
• Gene: SIX6 / 4990
• HGNCID: 10892
• Length: 246
• Species: Homo sapiens
• Sequence 2: NP_649256.1
• Gene: Six4 / 40297
• FlyBaseID: FBgn0027364
• Length: 392
• Species: Drosophila melanogaster
• Alignment Length: 210
• Identity: 109/210 - (51%)
• Similarity: 148/210 - (70%)
• Gaps: 10/210 - (4%)

Human     6 ILNFSPQQVAGVCETLEESGDVERLGRFLWSLPVAPAACEALNKNESVLRARAIVAFHGGNYREL 70
            :|.||..|:..:||.|::.||:|:|..||.|||.:    |....|||||||||:||::.|.:.||
  Fly   178 MLQFSTDQIQCMCEALQQKGDIEKLTTFLCSLPPS----EFFKTNESVLRARAMVAYNLGQFHEL 238

Human    71 YHILENHKFTKESHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCF 135
            |::||.|.|:.:.|..||.||.:|||:||||:||||||.|||||:|||:|||:||||||:..:||
  Fly   239 YNLLETHCFSIKYHVDLQNLWFKAHYKEAEKVRGRPLGAVDKYRLRKKYPLPKTIWDGEETVYCF 303

Human   136 KERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQQQVLSQG 200
            ||::|:.|::.||.:.||.|.:|:.||:.||||.|||.|||||||||||....:..: ..||..|
  Fly   304 KEKSRNALKDCYLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRRQRDRTPQQRPDI-MSVLPVG 367

Human   201 SGRALRAEGDGTPEV 215
                 :.:|:|.|.:
  Fly   368 -----QLDGNGFPRM 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIX6	NP_031400.2	SIX1_SD	9..122	CDD:318970	62/112 (55%)
		homeodomain	130..178	CDD:238039	24/47 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..246		6/26 (23%)
Six4	NP_649256.1	SIX1_SD	181..290	CDD:293483	62/112 (55%)
		homeodomain	301..355	CDD:238039	32/53 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0775
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810